An in vitro cytotoxicity of glufosfamide in HepG2 cells relative to its nonconjugated counterpart

Background Glufosfamide (β- d -glucosylisophosphoramide mustard, GLU) is an alkylating cytotoxic agent in which ifosforamide mustard (IPM) is glycosidically linked to the β- d -glucose molecule. GLU exerted its cytotoxic effect as a targeted chemotherapy. Although, its cytotoxic efficacy in a number...

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