Electroconvulsive therapy improves psychotic symptoms in patients with dementia with Lewy bodies
Purpose The aim of this study was to examine the efficacy and safety of electroconvulsive therapy (ECT) for psychotic symptoms of dementia with Lewy bodies (DLB), and also to determine its use as an adaptive criterion. Methods Eight patients aged 66–83 years old (mean 75.4 ± 5.9 years) diagnosed wit...
Gespeichert in:
| Veröffentlicht in: | International journal of geriatric psychiatry 2022-11, Vol.37 (11), p.n/a |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 11 |
| container_start_page | |
| container_title | International journal of geriatric psychiatry |
| container_volume | 37 |
| creator | Fukatsu, Takahide Kanemoto, Kosuke |
| description | Purpose
The aim of this study was to examine the efficacy and safety of electroconvulsive therapy (ECT) for psychotic symptoms of dementia with Lewy bodies (DLB), and also to determine its use as an adaptive criterion.
Methods
Eight patients aged 66–83 years old (mean 75.4 ± 5.9 years) diagnosed with probable DLB based on the criteria for DLB and who received ECT between September 2013 and December 2019 at Aichi Medical University were enrolled. The efficacy and safety of ECT were retrospectively examined. Psychotic symptoms were evaluated using the Brief Psychiatric Rating Scale (BPRS), while parkinsonism was evaluated based on Hoehn‐Yahr (HY) stage, with both scores analyzed and compared statistically between before and after ECT. Additionally, a follow‐up survey after undergoing ECT was performed.
Results
Two incidents occurred during ECT sessions, arrhythmia in one patient and respiratory arrest in another, both of whom quickly recovered. Following ECT, a significant improvement in BPRS score was noted (p |
| doi_str_mv | 10.1002/gps.5832 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2728450603</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2728450603</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3492-cd99b66890455b9c87b464379ece460f9c68e134983807144737cd0943f907533</originalsourceid><addsrcrecordid>eNp1kF1LwzAUhoMobk7BXyABb7zpTJo0TS5lzCkMFNTr2Kapy-iXSbrRf29m1TuvDi_n4T2HB4BLjOYYofj2o3PzhJP4CEwxEiLCmLFjMEWcJxGLCZqAM-e2CIUd5qdgQljMsUjIFLwvK628bVXb7PrKmZ2GfqNt1g3Q1J1td9rBzg1q03qjoBvqzre1g6aBXeaNbryDe-M3sNB1CCYb01rvB5i3hdHuHJyUWeX0xc-cgbf75eviIVo_rR4Xd-tIESriSBVC5IxxgWiS5ELxNKeMklRopSlDpVCMaxxQTjhKMaUpSVWBBCWlQGlCyAxcj73h6c9eOy-3bW-bcFLGacxpghg6UDcjpWzrnNWl7KypMztIjORBpQwq5UFlQK9-Cvu81sUf-OsuANEI7E2lh3-L5Or55bvwCyI7fUM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2728450603</pqid></control><display><type>article</type><title>Electroconvulsive therapy improves psychotic symptoms in patients with dementia with Lewy bodies</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Fukatsu, Takahide ; Kanemoto, Kosuke</creator><creatorcontrib>Fukatsu, Takahide ; Kanemoto, Kosuke</creatorcontrib><description>Purpose
The aim of this study was to examine the efficacy and safety of electroconvulsive therapy (ECT) for psychotic symptoms of dementia with Lewy bodies (DLB), and also to determine its use as an adaptive criterion.
Methods
Eight patients aged 66–83 years old (mean 75.4 ± 5.9 years) diagnosed with probable DLB based on the criteria for DLB and who received ECT between September 2013 and December 2019 at Aichi Medical University were enrolled. The efficacy and safety of ECT were retrospectively examined. Psychotic symptoms were evaluated using the Brief Psychiatric Rating Scale (BPRS), while parkinsonism was evaluated based on Hoehn‐Yahr (HY) stage, with both scores analyzed and compared statistically between before and after ECT. Additionally, a follow‐up survey after undergoing ECT was performed.
Results
Two incidents occurred during ECT sessions, arrhythmia in one patient and respiratory arrest in another, both of whom quickly recovered. Following ECT, a significant improvement in BPRS score was noted (p < 0.018, Wilcoxon signed rank test), whereas no significant difference was seen in regard to HY stage (p = 0.059). Follow‐up survey findings obtained after ECT (mean observation period 15.9 ± 16.7 months), showed that all eight patients were alive and none had a relapse of psychotic symptoms.
Conclusion
The present results suggest that ECT for patients with mild to moderate DLB and drug therapy‐resistant psychotic symptoms is safe, well tolerated and effective. We consider it worth considering as a DLB therapeutic option.
Key points
Eight patients with psychotic symptoms and diagnosed as having probable dementia with Lewy bodies (DLB) were enrolled.
Following electroconvulsive therapy (ECT) for drug therapy‐resistant DLB, a significant improvement in the Brief Psychiatric Rating Scale (BPRS) was noted in all patients (p < 0.018, Wilcoxon signed rank test). Two quickly recovered from incidents of arrhythmia and respiratory arrest that occurred during ECT.
The results indicate that ECT should considered as an adaptative criterion for drug therapy‐resistant patients with mild to moderate DLB who reject food or medicine, as well as suicidal ideation.
A follow‐up survey found that all eight patients were alive without relapse of psychotic symptoms (mean observation period 15.9 ± 16.7 months).</description><identifier>ISSN: 0885-6230</identifier><identifier>EISSN: 1099-1166</identifier><identifier>DOI: 10.1002/gps.5832</identifier><identifier>PMID: 36281953</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Aged ; Aged, 80 and over ; Arrhythmia ; Basal ganglia ; body mass index ; Brief Psychiatric Rating Scale ; Central nervous system diseases ; deep venous thrombus ; Dementia ; Dementia disorders ; dementia with Lewy bodies ; Drug therapy ; Electroconvulsive Therapy ; Geriatric psychiatry ; Humans ; Lewy bodies ; Lewy Body Disease - psychology ; Lewy Body Disease - therapy ; Movement disorders ; Patients ; Psychosis ; Psychotic Disorders - therapy ; psychotic symptoms ; Retrospective Studies ; Surveys</subject><ispartof>International journal of geriatric psychiatry, 2022-11, Vol.37 (11), p.n/a</ispartof><rights>2022 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3492-cd99b66890455b9c87b464379ece460f9c68e134983807144737cd0943f907533</citedby><cites>FETCH-LOGICAL-c3492-cd99b66890455b9c87b464379ece460f9c68e134983807144737cd0943f907533</cites><orcidid>0000-0002-6611-5244 ; 0000-0001-6019-030X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fgps.5832$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fgps.5832$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36281953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fukatsu, Takahide</creatorcontrib><creatorcontrib>Kanemoto, Kosuke</creatorcontrib><title>Electroconvulsive therapy improves psychotic symptoms in patients with dementia with Lewy bodies</title><title>International journal of geriatric psychiatry</title><addtitle>Int J Geriatr Psychiatry</addtitle><description>Purpose
The aim of this study was to examine the efficacy and safety of electroconvulsive therapy (ECT) for psychotic symptoms of dementia with Lewy bodies (DLB), and also to determine its use as an adaptive criterion.
Methods
Eight patients aged 66–83 years old (mean 75.4 ± 5.9 years) diagnosed with probable DLB based on the criteria for DLB and who received ECT between September 2013 and December 2019 at Aichi Medical University were enrolled. The efficacy and safety of ECT were retrospectively examined. Psychotic symptoms were evaluated using the Brief Psychiatric Rating Scale (BPRS), while parkinsonism was evaluated based on Hoehn‐Yahr (HY) stage, with both scores analyzed and compared statistically between before and after ECT. Additionally, a follow‐up survey after undergoing ECT was performed.
Results
Two incidents occurred during ECT sessions, arrhythmia in one patient and respiratory arrest in another, both of whom quickly recovered. Following ECT, a significant improvement in BPRS score was noted (p < 0.018, Wilcoxon signed rank test), whereas no significant difference was seen in regard to HY stage (p = 0.059). Follow‐up survey findings obtained after ECT (mean observation period 15.9 ± 16.7 months), showed that all eight patients were alive and none had a relapse of psychotic symptoms.
Conclusion
The present results suggest that ECT for patients with mild to moderate DLB and drug therapy‐resistant psychotic symptoms is safe, well tolerated and effective. We consider it worth considering as a DLB therapeutic option.
Key points
Eight patients with psychotic symptoms and diagnosed as having probable dementia with Lewy bodies (DLB) were enrolled.
Following electroconvulsive therapy (ECT) for drug therapy‐resistant DLB, a significant improvement in the Brief Psychiatric Rating Scale (BPRS) was noted in all patients (p < 0.018, Wilcoxon signed rank test). Two quickly recovered from incidents of arrhythmia and respiratory arrest that occurred during ECT.
The results indicate that ECT should considered as an adaptative criterion for drug therapy‐resistant patients with mild to moderate DLB who reject food or medicine, as well as suicidal ideation.
A follow‐up survey found that all eight patients were alive without relapse of psychotic symptoms (mean observation period 15.9 ± 16.7 months).</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arrhythmia</subject><subject>Basal ganglia</subject><subject>body mass index</subject><subject>Brief Psychiatric Rating Scale</subject><subject>Central nervous system diseases</subject><subject>deep venous thrombus</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>dementia with Lewy bodies</subject><subject>Drug therapy</subject><subject>Electroconvulsive Therapy</subject><subject>Geriatric psychiatry</subject><subject>Humans</subject><subject>Lewy bodies</subject><subject>Lewy Body Disease - psychology</subject><subject>Lewy Body Disease - therapy</subject><subject>Movement disorders</subject><subject>Patients</subject><subject>Psychosis</subject><subject>Psychotic Disorders - therapy</subject><subject>psychotic symptoms</subject><subject>Retrospective Studies</subject><subject>Surveys</subject><issn>0885-6230</issn><issn>1099-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF1LwzAUhoMobk7BXyABb7zpTJo0TS5lzCkMFNTr2Kapy-iXSbrRf29m1TuvDi_n4T2HB4BLjOYYofj2o3PzhJP4CEwxEiLCmLFjMEWcJxGLCZqAM-e2CIUd5qdgQljMsUjIFLwvK628bVXb7PrKmZ2GfqNt1g3Q1J1td9rBzg1q03qjoBvqzre1g6aBXeaNbryDe-M3sNB1CCYb01rvB5i3hdHuHJyUWeX0xc-cgbf75eviIVo_rR4Xd-tIESriSBVC5IxxgWiS5ELxNKeMklRopSlDpVCMaxxQTjhKMaUpSVWBBCWlQGlCyAxcj73h6c9eOy-3bW-bcFLGacxpghg6UDcjpWzrnNWl7KypMztIjORBpQwq5UFlQK9-Cvu81sUf-OsuANEI7E2lh3-L5Or55bvwCyI7fUM</recordid><startdate>202211</startdate><enddate>202211</enddate><creator>Fukatsu, Takahide</creator><creator>Kanemoto, Kosuke</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0002-6611-5244</orcidid><orcidid>https://orcid.org/0000-0001-6019-030X</orcidid></search><sort><creationdate>202211</creationdate><title>Electroconvulsive therapy improves psychotic symptoms in patients with dementia with Lewy bodies</title><author>Fukatsu, Takahide ; Kanemoto, Kosuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3492-cd99b66890455b9c87b464379ece460f9c68e134983807144737cd0943f907533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arrhythmia</topic><topic>Basal ganglia</topic><topic>body mass index</topic><topic>Brief Psychiatric Rating Scale</topic><topic>Central nervous system diseases</topic><topic>deep venous thrombus</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>dementia with Lewy bodies</topic><topic>Drug therapy</topic><topic>Electroconvulsive Therapy</topic><topic>Geriatric psychiatry</topic><topic>Humans</topic><topic>Lewy bodies</topic><topic>Lewy Body Disease - psychology</topic><topic>Lewy Body Disease - therapy</topic><topic>Movement disorders</topic><topic>Patients</topic><topic>Psychosis</topic><topic>Psychotic Disorders - therapy</topic><topic>psychotic symptoms</topic><topic>Retrospective Studies</topic><topic>Surveys</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukatsu, Takahide</creatorcontrib><creatorcontrib>Kanemoto, Kosuke</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>International journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukatsu, Takahide</au><au>Kanemoto, Kosuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electroconvulsive therapy improves psychotic symptoms in patients with dementia with Lewy bodies</atitle><jtitle>International journal of geriatric psychiatry</jtitle><addtitle>Int J Geriatr Psychiatry</addtitle><date>2022-11</date><risdate>2022</risdate><volume>37</volume><issue>11</issue><epage>n/a</epage><issn>0885-6230</issn><eissn>1099-1166</eissn><abstract>Purpose
The aim of this study was to examine the efficacy and safety of electroconvulsive therapy (ECT) for psychotic symptoms of dementia with Lewy bodies (DLB), and also to determine its use as an adaptive criterion.
Methods
Eight patients aged 66–83 years old (mean 75.4 ± 5.9 years) diagnosed with probable DLB based on the criteria for DLB and who received ECT between September 2013 and December 2019 at Aichi Medical University were enrolled. The efficacy and safety of ECT were retrospectively examined. Psychotic symptoms were evaluated using the Brief Psychiatric Rating Scale (BPRS), while parkinsonism was evaluated based on Hoehn‐Yahr (HY) stage, with both scores analyzed and compared statistically between before and after ECT. Additionally, a follow‐up survey after undergoing ECT was performed.
Results
Two incidents occurred during ECT sessions, arrhythmia in one patient and respiratory arrest in another, both of whom quickly recovered. Following ECT, a significant improvement in BPRS score was noted (p < 0.018, Wilcoxon signed rank test), whereas no significant difference was seen in regard to HY stage (p = 0.059). Follow‐up survey findings obtained after ECT (mean observation period 15.9 ± 16.7 months), showed that all eight patients were alive and none had a relapse of psychotic symptoms.
Conclusion
The present results suggest that ECT for patients with mild to moderate DLB and drug therapy‐resistant psychotic symptoms is safe, well tolerated and effective. We consider it worth considering as a DLB therapeutic option.
Key points
Eight patients with psychotic symptoms and diagnosed as having probable dementia with Lewy bodies (DLB) were enrolled.
Following electroconvulsive therapy (ECT) for drug therapy‐resistant DLB, a significant improvement in the Brief Psychiatric Rating Scale (BPRS) was noted in all patients (p < 0.018, Wilcoxon signed rank test). Two quickly recovered from incidents of arrhythmia and respiratory arrest that occurred during ECT.
The results indicate that ECT should considered as an adaptative criterion for drug therapy‐resistant patients with mild to moderate DLB who reject food or medicine, as well as suicidal ideation.
A follow‐up survey found that all eight patients were alive without relapse of psychotic symptoms (mean observation period 15.9 ± 16.7 months).</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36281953</pmid><doi>10.1002/gps.5832</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-6611-5244</orcidid><orcidid>https://orcid.org/0000-0001-6019-030X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0885-6230 |
| ispartof | International journal of geriatric psychiatry, 2022-11, Vol.37 (11), p.n/a |
| issn | 0885-6230 1099-1166 |
| language | eng |
| recordid | cdi_proquest_journals_2728450603 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Aged Aged, 80 and over Arrhythmia Basal ganglia body mass index Brief Psychiatric Rating Scale Central nervous system diseases deep venous thrombus Dementia Dementia disorders dementia with Lewy bodies Drug therapy Electroconvulsive Therapy Geriatric psychiatry Humans Lewy bodies Lewy Body Disease - psychology Lewy Body Disease - therapy Movement disorders Patients Psychosis Psychotic Disorders - therapy psychotic symptoms Retrospective Studies Surveys |
| title | Electroconvulsive therapy improves psychotic symptoms in patients with dementia with Lewy bodies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T12%3A44%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Electroconvulsive%20therapy%20improves%20psychotic%20symptoms%20in%20patients%20with%20dementia%20with%20Lewy%20bodies&rft.jtitle=International%20journal%20of%20geriatric%20psychiatry&rft.au=Fukatsu,%20Takahide&rft.date=2022-11&rft.volume=37&rft.issue=11&rft.epage=n/a&rft.issn=0885-6230&rft.eissn=1099-1166&rft_id=info:doi/10.1002/gps.5832&rft_dat=%3Cproquest_cross%3E2728450603%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2728450603&rft_id=info:pmid/36281953&rfr_iscdi=true |