PM2.5, PM10 and bronchiolitis severity: A cohort study

Background A few studies suggest that particulate matter (PM) exposure might play a role in bronchiolitis. However, available data are mostly focused on the risk of hospitalization and come from retrospective studies that provided conflicting results. This prospective study investigated the associat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Pediatric allergy and immunology 2022-10, Vol.33 (10), p.n/a
Hauptverfasser: Milani, Gregorio P., Cafora, Marco, Favero, Chiara, Luganini, Anna, Carugno, Michele, Lenzi, Erica, Pistocchi, Anna, Pinatel, Eva, Pariota, Luigi, Ferrari, Luca, Bollati, Valentina
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page n/a
container_issue 10
container_start_page
container_title Pediatric allergy and immunology
container_volume 33
creator Milani, Gregorio P.
Cafora, Marco
Favero, Chiara
Luganini, Anna
Carugno, Michele
Lenzi, Erica
Pistocchi, Anna
Pinatel, Eva
Pariota, Luigi
Ferrari, Luca
Bollati, Valentina
description Background A few studies suggest that particulate matter (PM) exposure might play a role in bronchiolitis. However, available data are mostly focused on the risk of hospitalization and come from retrospective studies that provided conflicting results. This prospective study investigated the association between PM (PM2.5 and PM10) exposure and the severity of bronchiolitis. Methods This prospective cohort study was conducted between November 2019 and February 2020 at the pediatric emergency department of the Fondazione IRCCS Ca′ Ospedale Maggiore Policlinico, Milan, Italy. Infants
doi_str_mv 10.1111/pai.13853
format Article
fullrecord <record><control><sourceid>proquest_wiley</sourceid><recordid>TN_cdi_proquest_journals_2728053344</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2728053344</sourcerecordid><originalsourceid>FETCH-LOGICAL-p2583-aadcac8d9f7da7e61af95b4e4cfa6bdc22593ff11e2e01b5eb1d6329ae7a671d3</originalsourceid><addsrcrecordid>eNotkDFPwzAUhC0EEqUw8A8ssZLWzy-2Y7aqolCpFR1gtpzYUV2VJtgpKP-e0HLL3XC6kz5C7oFNYNC0tWECWAi8ICNArTNkWFySEdNMZBKEuiY3Ke0YA4USRkRu1nwiHulmDYzag6NlbA7VNjT70IVEk__2MXT9E53Rqtk2saOpO7r-llzVdp_83b-Pycfi-X3-mq3eXpbz2SpruSgws9ZVtiqcrpWzykuwtRZl7vOqtrJ0FedCY10DeO4ZlMKX4CRybb2yUoHDMXk477ax-Tr61Jldc4yH4dJwxQsmEPN8aE3PrZ-w971pY_i0sTfAzB8TMzAxJyZmM1ueAv4C91hU3w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2728053344</pqid></control><display><type>article</type><title>PM2.5, PM10 and bronchiolitis severity: A cohort study</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Milani, Gregorio P. ; Cafora, Marco ; Favero, Chiara ; Luganini, Anna ; Carugno, Michele ; Lenzi, Erica ; Pistocchi, Anna ; Pinatel, Eva ; Pariota, Luigi ; Ferrari, Luca ; Bollati, Valentina</creator><creatorcontrib>Milani, Gregorio P. ; Cafora, Marco ; Favero, Chiara ; Luganini, Anna ; Carugno, Michele ; Lenzi, Erica ; Pistocchi, Anna ; Pinatel, Eva ; Pariota, Luigi ; Ferrari, Luca ; Bollati, Valentina</creatorcontrib><description>Background A few studies suggest that particulate matter (PM) exposure might play a role in bronchiolitis. However, available data are mostly focused on the risk of hospitalization and come from retrospective studies that provided conflicting results. This prospective study investigated the association between PM (PM2.5 and PM10) exposure and the severity of bronchiolitis. Methods This prospective cohort study was conducted between November 2019 and February 2020 at the pediatric emergency department of the Fondazione IRCCS Ca′ Ospedale Maggiore Policlinico, Milan, Italy. Infants &lt;1 year of age with bronchiolitis were eligible. The bronchiolitis severity score was assessed in each infant and a nasal swab was collected to detect respiratory viruses. The daily PM10 and PM2.5 exposure in the 29 preceding days were considered. Adjusted regression models were employed to evaluate the association between the severity score and PM10 and PM2.5 exposure. Results A positive association between the PM2.5 levels and the severity score was found at day‐2 (β 0.0214, 95% CI 0.0011–0.0417, p = .0386), day‐5 (β 0.0313, 95% CI 0.0054–0.0572, p = .0179), day‐14 (β 0.0284, 95% CI 0.0078–0.0490, p = .0069), day‐15 (β 0.0496, 95% CI 0.0242–0.0750, p = .0001) and day‐16 (β 0.0327, 95% CI 0.0080–0.0574, p = .0093).Similar figures were observed considering the PM10 exposure and limiting the analyses to infants with respiratory syncytial virus. Conclusion This study shows for the first time a direct association between PM2.5 and PM10 levels and the severity of bronchiolitis.</description><identifier>ISSN: 0905-6157</identifier><identifier>EISSN: 1399-3038</identifier><identifier>DOI: 10.1111/pai.13853</identifier><language>eng</language><publisher>Montpellier: Wiley Subscription Services, Inc</publisher><subject>air pollution ; bronchiolitis ; Bronchopneumonia ; Cohort analysis ; Emergency medical care ; environment ; Infants ; Particulate matter ; Pediatrics ; Regression analysis ; Respiratory syncytial virus ; severity</subject><ispartof>Pediatric allergy and immunology, 2022-10, Vol.33 (10), p.n/a</ispartof><rights>2022 The Authors. published by European Academy of Allergy and Clinical Immunology and John Wiley &amp; Sons Ltd.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-3829-4254</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpai.13853$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpai.13853$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids></links><search><creatorcontrib>Milani, Gregorio P.</creatorcontrib><creatorcontrib>Cafora, Marco</creatorcontrib><creatorcontrib>Favero, Chiara</creatorcontrib><creatorcontrib>Luganini, Anna</creatorcontrib><creatorcontrib>Carugno, Michele</creatorcontrib><creatorcontrib>Lenzi, Erica</creatorcontrib><creatorcontrib>Pistocchi, Anna</creatorcontrib><creatorcontrib>Pinatel, Eva</creatorcontrib><creatorcontrib>Pariota, Luigi</creatorcontrib><creatorcontrib>Ferrari, Luca</creatorcontrib><creatorcontrib>Bollati, Valentina</creatorcontrib><title>PM2.5, PM10 and bronchiolitis severity: A cohort study</title><title>Pediatric allergy and immunology</title><description>Background A few studies suggest that particulate matter (PM) exposure might play a role in bronchiolitis. However, available data are mostly focused on the risk of hospitalization and come from retrospective studies that provided conflicting results. This prospective study investigated the association between PM (PM2.5 and PM10) exposure and the severity of bronchiolitis. Methods This prospective cohort study was conducted between November 2019 and February 2020 at the pediatric emergency department of the Fondazione IRCCS Ca′ Ospedale Maggiore Policlinico, Milan, Italy. Infants &lt;1 year of age with bronchiolitis were eligible. The bronchiolitis severity score was assessed in each infant and a nasal swab was collected to detect respiratory viruses. The daily PM10 and PM2.5 exposure in the 29 preceding days were considered. Adjusted regression models were employed to evaluate the association between the severity score and PM10 and PM2.5 exposure. Results A positive association between the PM2.5 levels and the severity score was found at day‐2 (β 0.0214, 95% CI 0.0011–0.0417, p = .0386), day‐5 (β 0.0313, 95% CI 0.0054–0.0572, p = .0179), day‐14 (β 0.0284, 95% CI 0.0078–0.0490, p = .0069), day‐15 (β 0.0496, 95% CI 0.0242–0.0750, p = .0001) and day‐16 (β 0.0327, 95% CI 0.0080–0.0574, p = .0093).Similar figures were observed considering the PM10 exposure and limiting the analyses to infants with respiratory syncytial virus. Conclusion This study shows for the first time a direct association between PM2.5 and PM10 levels and the severity of bronchiolitis.</description><subject>air pollution</subject><subject>bronchiolitis</subject><subject>Bronchopneumonia</subject><subject>Cohort analysis</subject><subject>Emergency medical care</subject><subject>environment</subject><subject>Infants</subject><subject>Particulate matter</subject><subject>Pediatrics</subject><subject>Regression analysis</subject><subject>Respiratory syncytial virus</subject><subject>severity</subject><issn>0905-6157</issn><issn>1399-3038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNotkDFPwzAUhC0EEqUw8A8ssZLWzy-2Y7aqolCpFR1gtpzYUV2VJtgpKP-e0HLL3XC6kz5C7oFNYNC0tWECWAi8ICNArTNkWFySEdNMZBKEuiY3Ke0YA4USRkRu1nwiHulmDYzag6NlbA7VNjT70IVEk__2MXT9E53Rqtk2saOpO7r-llzVdp_83b-Pycfi-X3-mq3eXpbz2SpruSgws9ZVtiqcrpWzykuwtRZl7vOqtrJ0FedCY10DeO4ZlMKX4CRybb2yUoHDMXk477ax-Tr61Jldc4yH4dJwxQsmEPN8aE3PrZ-w971pY_i0sTfAzB8TMzAxJyZmM1ueAv4C91hU3w</recordid><startdate>202210</startdate><enddate>202210</enddate><creator>Milani, Gregorio P.</creator><creator>Cafora, Marco</creator><creator>Favero, Chiara</creator><creator>Luganini, Anna</creator><creator>Carugno, Michele</creator><creator>Lenzi, Erica</creator><creator>Pistocchi, Anna</creator><creator>Pinatel, Eva</creator><creator>Pariota, Luigi</creator><creator>Ferrari, Luca</creator><creator>Bollati, Valentina</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><orcidid>https://orcid.org/0000-0003-3829-4254</orcidid></search><sort><creationdate>202210</creationdate><title>PM2.5, PM10 and bronchiolitis severity: A cohort study</title><author>Milani, Gregorio P. ; Cafora, Marco ; Favero, Chiara ; Luganini, Anna ; Carugno, Michele ; Lenzi, Erica ; Pistocchi, Anna ; Pinatel, Eva ; Pariota, Luigi ; Ferrari, Luca ; Bollati, Valentina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2583-aadcac8d9f7da7e61af95b4e4cfa6bdc22593ff11e2e01b5eb1d6329ae7a671d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>air pollution</topic><topic>bronchiolitis</topic><topic>Bronchopneumonia</topic><topic>Cohort analysis</topic><topic>Emergency medical care</topic><topic>environment</topic><topic>Infants</topic><topic>Particulate matter</topic><topic>Pediatrics</topic><topic>Regression analysis</topic><topic>Respiratory syncytial virus</topic><topic>severity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Milani, Gregorio P.</creatorcontrib><creatorcontrib>Cafora, Marco</creatorcontrib><creatorcontrib>Favero, Chiara</creatorcontrib><creatorcontrib>Luganini, Anna</creatorcontrib><creatorcontrib>Carugno, Michele</creatorcontrib><creatorcontrib>Lenzi, Erica</creatorcontrib><creatorcontrib>Pistocchi, Anna</creatorcontrib><creatorcontrib>Pinatel, Eva</creatorcontrib><creatorcontrib>Pariota, Luigi</creatorcontrib><creatorcontrib>Ferrari, Luca</creatorcontrib><creatorcontrib>Bollati, Valentina</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><jtitle>Pediatric allergy and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Milani, Gregorio P.</au><au>Cafora, Marco</au><au>Favero, Chiara</au><au>Luganini, Anna</au><au>Carugno, Michele</au><au>Lenzi, Erica</au><au>Pistocchi, Anna</au><au>Pinatel, Eva</au><au>Pariota, Luigi</au><au>Ferrari, Luca</au><au>Bollati, Valentina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PM2.5, PM10 and bronchiolitis severity: A cohort study</atitle><jtitle>Pediatric allergy and immunology</jtitle><date>2022-10</date><risdate>2022</risdate><volume>33</volume><issue>10</issue><epage>n/a</epage><issn>0905-6157</issn><eissn>1399-3038</eissn><abstract>Background A few studies suggest that particulate matter (PM) exposure might play a role in bronchiolitis. However, available data are mostly focused on the risk of hospitalization and come from retrospective studies that provided conflicting results. This prospective study investigated the association between PM (PM2.5 and PM10) exposure and the severity of bronchiolitis. Methods This prospective cohort study was conducted between November 2019 and February 2020 at the pediatric emergency department of the Fondazione IRCCS Ca′ Ospedale Maggiore Policlinico, Milan, Italy. Infants &lt;1 year of age with bronchiolitis were eligible. The bronchiolitis severity score was assessed in each infant and a nasal swab was collected to detect respiratory viruses. The daily PM10 and PM2.5 exposure in the 29 preceding days were considered. Adjusted regression models were employed to evaluate the association between the severity score and PM10 and PM2.5 exposure. Results A positive association between the PM2.5 levels and the severity score was found at day‐2 (β 0.0214, 95% CI 0.0011–0.0417, p = .0386), day‐5 (β 0.0313, 95% CI 0.0054–0.0572, p = .0179), day‐14 (β 0.0284, 95% CI 0.0078–0.0490, p = .0069), day‐15 (β 0.0496, 95% CI 0.0242–0.0750, p = .0001) and day‐16 (β 0.0327, 95% CI 0.0080–0.0574, p = .0093).Similar figures were observed considering the PM10 exposure and limiting the analyses to infants with respiratory syncytial virus. Conclusion This study shows for the first time a direct association between PM2.5 and PM10 levels and the severity of bronchiolitis.</abstract><cop>Montpellier</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/pai.13853</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3829-4254</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0905-6157
ispartof Pediatric allergy and immunology, 2022-10, Vol.33 (10), p.n/a
issn 0905-6157
1399-3038
language eng
recordid cdi_proquest_journals_2728053344
source Wiley Online Library Journals Frontfile Complete
subjects air pollution
bronchiolitis
Bronchopneumonia
Cohort analysis
Emergency medical care
environment
Infants
Particulate matter
Pediatrics
Regression analysis
Respiratory syncytial virus
severity
title PM2.5, PM10 and bronchiolitis severity: A cohort study
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T03%3A57%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_wiley&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=PM2.5,%20PM10%20and%20bronchiolitis%20severity:%20A%20cohort%20study&rft.jtitle=Pediatric%20allergy%20and%20immunology&rft.au=Milani,%20Gregorio%20P.&rft.date=2022-10&rft.volume=33&rft.issue=10&rft.epage=n/a&rft.issn=0905-6157&rft.eissn=1399-3038&rft_id=info:doi/10.1111/pai.13853&rft_dat=%3Cproquest_wiley%3E2728053344%3C/proquest_wiley%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2728053344&rft_id=info:pmid/&rfr_iscdi=true