Design and synthesis of thiazolidine-2,4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico studies

A thiazolidine-2,4-dione nucleus was molecularly hybridised with the effective antitumor moieties; 2-oxo-1,2-dihydroquinoline and 2-oxoindoline to obtain new hybrids with potential activity against VEGFR-2. The cytotoxic effects of the synthesised derivatives against Caco-2, HepG-2, and MDA-MB-231 c...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2022-12, Vol.37 (1), p.1903-1917
Hauptverfasser:	Taghour, Mohammed S., Elkady, Hazem, Eldehna, Wagdy M., El-Deeb, Nehal M., Kenawy, Ahmed M., Elkaeed, Eslam B., Alsfouk, Aisha A., Alesawy, Mohamed S., Metwaly, Ahmed M., Eissa, Ibrahim. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Oxo-1,2-dihydroquinoline 2-Oxoindoline anticancer Antitumor activity Apoptosis Bcl-x protein Binding sites Biotechnology Cancer Cell growth Cell lines Chemical synthesis Chemistry Cytotoxicity Gene expression Genetic engineering Herbal medicine Hybrids Kinases Pharmaceutical sciences Pharmacy Research Paper Survivin Thiazolidine-2,4-dione Vascular endothelial growth factor receptors VEGFR-2 inhibitors
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