Efficacy of Lamiaceae essential oils with selected azoles against Candida albicans clinical isolates
A current problem in candidiasis treatment is increasing resistance to azoles, which are often prescribed to patients. The study underlines the high resistance of yeasts to fluconazole, which achieved high MIC (minimal inhibitory concentration) values both alone and in combination with essential oil...
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| Veröffentlicht in: | Polish journal of veterinary sciences 2022-01, Vol.25 (2), p.279-285 |
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| creator | Proškovcová, M Čonková, E Váczi, P Marcinčáková, D Harčárová, M |
| description | A current problem in candidiasis treatment is increasing resistance to azoles, which are often prescribed to patients. The study underlines the high resistance of yeasts to fluconazole, which achieved high MIC (minimal inhibitory concentration) values both alone and in combination with essential oils (EOs). Antifungal activity of Hyssopus officinalis, Thymus vulgaris, Salvia officinalis and Rosmarinus officinalis EOs was determined against 13 clinical isolates of Candida albicans and reference strain Candida albicans ATCC 10231. The synergistic effect was investigated for the combination of itraconazole and fluconazole with Hyssopus officinalis and Thymus vulgaris EOs. Based on the fractional inhibitory concentration index, the synergistic effect was achieved in all of the samples exposed to itraconazole with Hyssopus officinalis (FICI 0.3±0.06). On the other side, the additive effect was proven in use of itraconazole with Thymus vulgaris (FICI 0.75±0.35) and fluconazole with both EOs tested (FICI 0.81±0.19; 0.88±0.57) This study shows the importance of monitoring the synergistic effect of antifungals combined with EOs, because it is a possible solution for reducing the resistance and improving the disease prognosis. |
| doi_str_mv | 10.24425/pjvs.2022.141812 |
| format | Article |
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The study underlines the high resistance of yeasts to fluconazole, which achieved high MIC (minimal inhibitory concentration) values both alone and in combination with essential oils (EOs). Antifungal activity of Hyssopus officinalis, Thymus vulgaris, Salvia officinalis and Rosmarinus officinalis EOs was determined against 13 clinical isolates of Candida albicans and reference strain Candida albicans ATCC 10231. The synergistic effect was investigated for the combination of itraconazole and fluconazole with Hyssopus officinalis and Thymus vulgaris EOs. Based on the fractional inhibitory concentration index, the synergistic effect was achieved in all of the samples exposed to itraconazole with Hyssopus officinalis (FICI 0.3±0.06). On the other side, the additive effect was proven in use of itraconazole with Thymus vulgaris (FICI 0.75±0.35) and fluconazole with both EOs tested (FICI 0.81±0.19; 0.88±0.57) This study shows the importance of monitoring the synergistic effect of antifungals combined with EOs, because it is a possible solution for reducing the resistance and improving the disease prognosis.</description><identifier>ISSN: 1505-1773</identifier><identifier>EISSN: 2300-2557</identifier><identifier>DOI: 10.24425/pjvs.2022.141812</identifier><language>eng</language><publisher>Warsaw: Polish Academy of Sciences, Committee of Veterinary Sciences</publisher><subject>Antifungal activity ; Antifungal agents ; Azoles ; Biosynthesis ; Candida albicans ; Candidiasis ; Clinical isolates ; Clinical medicine ; Disease resistance ; Essential oils ; Fluconazole ; Fungal infections ; Hyssopus officinalis ; Itraconazole ; Laboratories ; Minimum inhibitory concentration ; Mortality ; Oils & fats ; Pathogens ; Sterols ; Thymus vulgaris ; Yeast</subject><ispartof>Polish journal of veterinary sciences, 2022-01, Vol.25 (2), p.279-285</ispartof><rights>Copyright Polish Academy of Sciences, Committee of Veterinary Sciences 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Proškovcová, M</creatorcontrib><creatorcontrib>Čonková, E</creatorcontrib><creatorcontrib>Váczi, P</creatorcontrib><creatorcontrib>Marcinčáková, D</creatorcontrib><creatorcontrib>Harčárová, M</creatorcontrib><title>Efficacy of Lamiaceae essential oils with selected azoles against Candida albicans clinical isolates</title><title>Polish journal of veterinary sciences</title><description>A current problem in candidiasis treatment is increasing resistance to azoles, which are often prescribed to patients. 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On the other side, the additive effect was proven in use of itraconazole with Thymus vulgaris (FICI 0.75±0.35) and fluconazole with both EOs tested (FICI 0.81±0.19; 0.88±0.57) This study shows the importance of monitoring the synergistic effect of antifungals combined with EOs, because it is a possible solution for reducing the resistance and improving the disease prognosis.</description><subject>Antifungal activity</subject><subject>Antifungal agents</subject><subject>Azoles</subject><subject>Biosynthesis</subject><subject>Candida albicans</subject><subject>Candidiasis</subject><subject>Clinical isolates</subject><subject>Clinical medicine</subject><subject>Disease resistance</subject><subject>Essential oils</subject><subject>Fluconazole</subject><subject>Fungal infections</subject><subject>Hyssopus officinalis</subject><subject>Itraconazole</subject><subject>Laboratories</subject><subject>Minimum inhibitory concentration</subject><subject>Mortality</subject><subject>Oils & fats</subject><subject>Pathogens</subject><subject>Sterols</subject><subject>Thymus vulgaris</subject><subject>Yeast</subject><issn>1505-1773</issn><issn>2300-2557</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNotj01Lw0AURQdRsFZ_gLsB16lvvpOllGqFghtdl5fJG50yJrUvVfTXG9DVvatz7hXiWsFCW6vd7X73yQsNWi-UVbXSJ2KmDUClnQunYqYcuEqFYM7FBfMOwDem9jPRrVLKEeO3HJLc4HvGSEiSmKkfMxY55MLyK49vkqlQHKmT-DMUYomvmHse5RL7LncosbQTqWcZS-6nVmTmoeBIfCnOEhamq_-ci5f71fNyXW2eHh6Xd5tqr10zVh5bAActhnq60NnURYUIENsQTVJAMI1rrNJo68Y3juqQMHmyDTrrfTJzcfPH3R-GjyPxuN0Nx0M_Kbc66BC0scGZX5rxWf8</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Proškovcová, M</creator><creator>Čonková, E</creator><creator>Váczi, P</creator><creator>Marcinčáková, D</creator><creator>Harčárová, M</creator><general>Polish Academy of Sciences, Committee of Veterinary Sciences</general><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20220101</creationdate><title>Efficacy of Lamiaceae essential oils with selected azoles against Candida albicans clinical isolates</title><author>Proškovcová, M ; Čonková, E ; Váczi, P ; Marcinčáková, D ; Harčárová, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p259t-6ab0050ba78418d4fdc1aa00cb7c3f10e0ace9412a489695e87faf6e49a5466f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antifungal activity</topic><topic>Antifungal agents</topic><topic>Azoles</topic><topic>Biosynthesis</topic><topic>Candida albicans</topic><topic>Candidiasis</topic><topic>Clinical isolates</topic><topic>Clinical medicine</topic><topic>Disease resistance</topic><topic>Essential oils</topic><topic>Fluconazole</topic><topic>Fungal infections</topic><topic>Hyssopus officinalis</topic><topic>Itraconazole</topic><topic>Laboratories</topic><topic>Minimum inhibitory concentration</topic><topic>Mortality</topic><topic>Oils & fats</topic><topic>Pathogens</topic><topic>Sterols</topic><topic>Thymus vulgaris</topic><topic>Yeast</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Proškovcová, M</creatorcontrib><creatorcontrib>Čonková, E</creatorcontrib><creatorcontrib>Váczi, P</creatorcontrib><creatorcontrib>Marcinčáková, D</creatorcontrib><creatorcontrib>Harčárová, M</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Polish journal of veterinary sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Proškovcová, M</au><au>Čonková, E</au><au>Váczi, P</au><au>Marcinčáková, D</au><au>Harčárová, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of Lamiaceae essential oils with selected azoles against Candida albicans clinical isolates</atitle><jtitle>Polish journal of veterinary sciences</jtitle><date>2022-01-01</date><risdate>2022</risdate><volume>25</volume><issue>2</issue><spage>279</spage><epage>285</epage><pages>279-285</pages><issn>1505-1773</issn><eissn>2300-2557</eissn><abstract>A current problem in candidiasis treatment is increasing resistance to azoles, which are often prescribed to patients. 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On the other side, the additive effect was proven in use of itraconazole with Thymus vulgaris (FICI 0.75±0.35) and fluconazole with both EOs tested (FICI 0.81±0.19; 0.88±0.57) This study shows the importance of monitoring the synergistic effect of antifungals combined with EOs, because it is a possible solution for reducing the resistance and improving the disease prognosis.</abstract><cop>Warsaw</cop><pub>Polish Academy of Sciences, Committee of Veterinary Sciences</pub><doi>10.24425/pjvs.2022.141812</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antifungal activity Antifungal agents Azoles Biosynthesis Candida albicans Candidiasis Clinical isolates Clinical medicine Disease resistance Essential oils Fluconazole Fungal infections Hyssopus officinalis Itraconazole Laboratories Minimum inhibitory concentration Mortality Oils & fats Pathogens Sterols Thymus vulgaris Yeast |
| title | Efficacy of Lamiaceae essential oils with selected azoles against Candida albicans clinical isolates |
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