Palladium‐Catalyzed Dehydrogenative Synthesis of Imidazoquinolines in Water

We report a synthesis of imidazoquinolines via dehydrogenative coupling of 3,4‐diaminoquinolines with benzylic alcohols utilizing our π‐benzylpalladium(II) system in water. Readily available benzylic alcohols initially undergo catalytic dehydrogenation to form benzaldehydes, which are then reacted w...

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Veröffentlicht in:	Asian journal of organic chemistry 2022-10, Vol.11 (10), p.n/a
Hauptverfasser:	Nakayama, Taku, Harada, Shogo, Kikkawa, Shoko, Hikawa, Hidemasa, Azumaya, Isao
Format:	Artikel
Sprache:	eng
Schlagworte:	Additives Alcohol Benzyl alcohol benzyl alcohol, dehydrogenative coupling Chemical synthesis Coupling (molecular) Dehydrogenation imidazoquinolines Isotope effect Organic chemistry Oxidation Oxidizing agents Palladium Reaction mechanisms Substrates water Water chemistry
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