Synthesis, HSA-Binding and Anticancer Properties of [Cu2(μ-dppm)2(N^N)2]2
A set of dinuclear copper(I) complexes with the general formula [Cu 2 (μ-dppm) 2 (N^N) 2 ] 2+ were synthesized and characterized by 1 HNMR, 31 PNMR, and elemental analysis. The high-resolution mass spectra clearly illustrated isotopic pattern for the proposed dinuclear systems. The binding of the co...
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| Veröffentlicht in: | Journal of inorganic and organometallic polymers and materials 2022, Vol.32 (10), p.4005-4013 |
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| creator | Babgi, Bandar A. Alzaidi, Najah A. Alsayari, Jalal H. Emwas, Abdul-Hamid M. Jaremko, Mariusz Abdellattif, Magda H. Aljahdali, Mutlaq Hussien, Mostafa A. |
| description | A set of dinuclear copper(I) complexes with the general formula [Cu
2
(μ-dppm)
2
(N^N)
2
]
2+
were synthesized and characterized by
1
HNMR,
31
PNMR, and elemental analysis. The high-resolution mass spectra clearly illustrated isotopic pattern for the proposed dinuclear systems. The binding of the complexes toward human serum albumin (HSA) were evaluated, highlighting good binding affinities influenced by the nature of the substituted-diimine. The complexes induce changes in both the α-helix and the microenvironment structures of HSA. The HSA-bindings were modelled by molecular docking; [Cu
2
(μ-dppm)
2
(dppz)
2
][ClO
4
]
2
(
3
) displays the highest binding score toward HSA due to the ability of dppz in establishing π-interactions. The anticancer properties of
1
,
2
and
3
were screened against COLO 205, RCC-PR, HepGII and LLC-MK2 cell lines and the results were discussed. Complex
3
has better IC
50
against all the cancer cell lines than that observed for cisplatin, but still lower than the cytotoxicity of Sunitinib. Moreover, complex
3
has higher selectivity towards cancer cells over normal cells when compared to cisplatin and sunitinib.
Graphical Abstract |
| doi_str_mv | 10.1007/s10904-022-02404-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2725634537</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2725634537</sourcerecordid><originalsourceid>FETCH-LOGICAL-c208y-7e2921d1fd21e05e18dac1b38c7167ff8f08c1d5038ee9f6f208735bfdf11a7f3</originalsourceid><addsrcrecordid>eNp9kE1OwzAQhS0EEqVwAVaR2LQSBo8d1-myVEBBVUEqrBBYqX9KKuqkdrrI3TgDZ8IQBDsWo3mL970ZPYSOgZwBIeI8ABmSFBNK46RRNTuoA1ykGFIOu786ZfvoIIQVISwjHDrodt64-tWEIpwmk_kIXxROF26Z5E4nI1cXKnfK-OTel5XxdWFCUtrkabylvY93rKtq3ae92cusT5_pIdqz-VswRz-7ix6vLh_GEzy9u74Zj6ZYUZI1WBg6pKDBagqGcAOZzhUsWKYEDIS1mSWZAs3jh8YM7cBGSjC-sNoC5MKyLjppcytfbrYm1HJVbr2LJyUVlA9YypmILtq6lC9D8MbKyhfr3DcSiPzqTLadydiZ_O5MNhFiLRSi2S2N_4v-h_oEekRt1w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2725634537</pqid></control><display><type>article</type><title>Synthesis, HSA-Binding and Anticancer Properties of [Cu2(μ-dppm)2(N^N)2]2</title><source>SpringerLink Journals</source><creator>Babgi, Bandar A. ; Alzaidi, Najah A. ; Alsayari, Jalal H. ; Emwas, Abdul-Hamid M. ; Jaremko, Mariusz ; Abdellattif, Magda H. ; Aljahdali, Mutlaq ; Hussien, Mostafa A.</creator><creatorcontrib>Babgi, Bandar A. ; Alzaidi, Najah A. ; Alsayari, Jalal H. ; Emwas, Abdul-Hamid M. ; Jaremko, Mariusz ; Abdellattif, Magda H. ; Aljahdali, Mutlaq ; Hussien, Mostafa A.</creatorcontrib><description>A set of dinuclear copper(I) complexes with the general formula [Cu
2
(μ-dppm)
2
(N^N)
2
]
2+
were synthesized and characterized by
1
HNMR,
31
PNMR, and elemental analysis. The high-resolution mass spectra clearly illustrated isotopic pattern for the proposed dinuclear systems. The binding of the complexes toward human serum albumin (HSA) were evaluated, highlighting good binding affinities influenced by the nature of the substituted-diimine. The complexes induce changes in both the α-helix and the microenvironment structures of HSA. The HSA-bindings were modelled by molecular docking; [Cu
2
(μ-dppm)
2
(dppz)
2
][ClO
4
]
2
(
3
) displays the highest binding score toward HSA due to the ability of dppz in establishing π-interactions. The anticancer properties of
1
,
2
and
3
were screened against COLO 205, RCC-PR, HepGII and LLC-MK2 cell lines and the results were discussed. Complex
3
has better IC
50
against all the cancer cell lines than that observed for cisplatin, but still lower than the cytotoxicity of Sunitinib. Moreover, complex
3
has higher selectivity towards cancer cells over normal cells when compared to cisplatin and sunitinib.
Graphical Abstract</description><identifier>ISSN: 1574-1443</identifier><identifier>EISSN: 1574-1451</identifier><identifier>DOI: 10.1007/s10904-022-02404-y</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Anticancer properties ; Binding ; Cancer ; Chemistry ; Chemistry and Materials Science ; Inorganic Chemistry ; Mass spectra ; Molecular docking ; Organic Chemistry ; Polymer Sciences ; Selectivity ; Serum albumin ; Toxicity</subject><ispartof>Journal of inorganic and organometallic polymers and materials, 2022, Vol.32 (10), p.4005-4013</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c208y-7e2921d1fd21e05e18dac1b38c7167ff8f08c1d5038ee9f6f208735bfdf11a7f3</citedby><cites>FETCH-LOGICAL-c208y-7e2921d1fd21e05e18dac1b38c7167ff8f08c1d5038ee9f6f208735bfdf11a7f3</cites><orcidid>0000-0002-9364-263X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10904-022-02404-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10904-022-02404-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Babgi, Bandar A.</creatorcontrib><creatorcontrib>Alzaidi, Najah A.</creatorcontrib><creatorcontrib>Alsayari, Jalal H.</creatorcontrib><creatorcontrib>Emwas, Abdul-Hamid M.</creatorcontrib><creatorcontrib>Jaremko, Mariusz</creatorcontrib><creatorcontrib>Abdellattif, Magda H.</creatorcontrib><creatorcontrib>Aljahdali, Mutlaq</creatorcontrib><creatorcontrib>Hussien, Mostafa A.</creatorcontrib><title>Synthesis, HSA-Binding and Anticancer Properties of [Cu2(μ-dppm)2(N^N)2]2</title><title>Journal of inorganic and organometallic polymers and materials</title><addtitle>J Inorg Organomet Polym</addtitle><description>A set of dinuclear copper(I) complexes with the general formula [Cu
2
(μ-dppm)
2
(N^N)
2
]
2+
were synthesized and characterized by
1
HNMR,
31
PNMR, and elemental analysis. The high-resolution mass spectra clearly illustrated isotopic pattern for the proposed dinuclear systems. The binding of the complexes toward human serum albumin (HSA) were evaluated, highlighting good binding affinities influenced by the nature of the substituted-diimine. The complexes induce changes in both the α-helix and the microenvironment structures of HSA. The HSA-bindings were modelled by molecular docking; [Cu
2
(μ-dppm)
2
(dppz)
2
][ClO
4
]
2
(
3
) displays the highest binding score toward HSA due to the ability of dppz in establishing π-interactions. The anticancer properties of
1
,
2
and
3
were screened against COLO 205, RCC-PR, HepGII and LLC-MK2 cell lines and the results were discussed. Complex
3
has better IC
50
against all the cancer cell lines than that observed for cisplatin, but still lower than the cytotoxicity of Sunitinib. Moreover, complex
3
has higher selectivity towards cancer cells over normal cells when compared to cisplatin and sunitinib.
Graphical Abstract</description><subject>Anticancer properties</subject><subject>Binding</subject><subject>Cancer</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Inorganic Chemistry</subject><subject>Mass spectra</subject><subject>Molecular docking</subject><subject>Organic Chemistry</subject><subject>Polymer Sciences</subject><subject>Selectivity</subject><subject>Serum albumin</subject><subject>Toxicity</subject><issn>1574-1443</issn><issn>1574-1451</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kE1OwzAQhS0EEqVwAVaR2LQSBo8d1-myVEBBVUEqrBBYqX9KKuqkdrrI3TgDZ8IQBDsWo3mL970ZPYSOgZwBIeI8ABmSFBNK46RRNTuoA1ykGFIOu786ZfvoIIQVISwjHDrodt64-tWEIpwmk_kIXxROF26Z5E4nI1cXKnfK-OTel5XxdWFCUtrkabylvY93rKtq3ae92cusT5_pIdqz-VswRz-7ix6vLh_GEzy9u74Zj6ZYUZI1WBg6pKDBagqGcAOZzhUsWKYEDIS1mSWZAs3jh8YM7cBGSjC-sNoC5MKyLjppcytfbrYm1HJVbr2LJyUVlA9YypmILtq6lC9D8MbKyhfr3DcSiPzqTLadydiZ_O5MNhFiLRSi2S2N_4v-h_oEekRt1w</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Babgi, Bandar A.</creator><creator>Alzaidi, Najah A.</creator><creator>Alsayari, Jalal H.</creator><creator>Emwas, Abdul-Hamid M.</creator><creator>Jaremko, Mariusz</creator><creator>Abdellattif, Magda H.</creator><creator>Aljahdali, Mutlaq</creator><creator>Hussien, Mostafa A.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-9364-263X</orcidid></search><sort><creationdate>2022</creationdate><title>Synthesis, HSA-Binding and Anticancer Properties of [Cu2(μ-dppm)2(N^N)2]2</title><author>Babgi, Bandar A. ; Alzaidi, Najah A. ; Alsayari, Jalal H. ; Emwas, Abdul-Hamid M. ; Jaremko, Mariusz ; Abdellattif, Magda H. ; Aljahdali, Mutlaq ; Hussien, Mostafa A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c208y-7e2921d1fd21e05e18dac1b38c7167ff8f08c1d5038ee9f6f208735bfdf11a7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anticancer properties</topic><topic>Binding</topic><topic>Cancer</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Inorganic Chemistry</topic><topic>Mass spectra</topic><topic>Molecular docking</topic><topic>Organic Chemistry</topic><topic>Polymer Sciences</topic><topic>Selectivity</topic><topic>Serum albumin</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Babgi, Bandar A.</creatorcontrib><creatorcontrib>Alzaidi, Najah A.</creatorcontrib><creatorcontrib>Alsayari, Jalal H.</creatorcontrib><creatorcontrib>Emwas, Abdul-Hamid M.</creatorcontrib><creatorcontrib>Jaremko, Mariusz</creatorcontrib><creatorcontrib>Abdellattif, Magda H.</creatorcontrib><creatorcontrib>Aljahdali, Mutlaq</creatorcontrib><creatorcontrib>Hussien, Mostafa A.</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of inorganic and organometallic polymers and materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Babgi, Bandar A.</au><au>Alzaidi, Najah A.</au><au>Alsayari, Jalal H.</au><au>Emwas, Abdul-Hamid M.</au><au>Jaremko, Mariusz</au><au>Abdellattif, Magda H.</au><au>Aljahdali, Mutlaq</au><au>Hussien, Mostafa A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, HSA-Binding and Anticancer Properties of [Cu2(μ-dppm)2(N^N)2]2</atitle><jtitle>Journal of inorganic and organometallic polymers and materials</jtitle><stitle>J Inorg Organomet Polym</stitle><date>2022</date><risdate>2022</risdate><volume>32</volume><issue>10</issue><spage>4005</spage><epage>4013</epage><pages>4005-4013</pages><issn>1574-1443</issn><eissn>1574-1451</eissn><abstract>A set of dinuclear copper(I) complexes with the general formula [Cu
2
(μ-dppm)
2
(N^N)
2
]
2+
were synthesized and characterized by
1
HNMR,
31
PNMR, and elemental analysis. The high-resolution mass spectra clearly illustrated isotopic pattern for the proposed dinuclear systems. The binding of the complexes toward human serum albumin (HSA) were evaluated, highlighting good binding affinities influenced by the nature of the substituted-diimine. The complexes induce changes in both the α-helix and the microenvironment structures of HSA. The HSA-bindings were modelled by molecular docking; [Cu
2
(μ-dppm)
2
(dppz)
2
][ClO
4
]
2
(
3
) displays the highest binding score toward HSA due to the ability of dppz in establishing π-interactions. The anticancer properties of
1
,
2
and
3
were screened against COLO 205, RCC-PR, HepGII and LLC-MK2 cell lines and the results were discussed. Complex
3
has better IC
50
against all the cancer cell lines than that observed for cisplatin, but still lower than the cytotoxicity of Sunitinib. Moreover, complex
3
has higher selectivity towards cancer cells over normal cells when compared to cisplatin and sunitinib.
Graphical Abstract</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10904-022-02404-y</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9364-263X</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| subjects | Anticancer properties Binding Cancer Chemistry Chemistry and Materials Science Inorganic Chemistry Mass spectra Molecular docking Organic Chemistry Polymer Sciences Selectivity Serum albumin Toxicity |
| title | Synthesis, HSA-Binding and Anticancer Properties of [Cu2(μ-dppm)2(N^N)2]2 |
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