The prenatal and postnatal effects of air pollution on asthma in children with atopic dermatitis
Objectives Air pollution is strongly associated with asthma, but has not been determined to induce new‐onset asthma development in children with atopic dermatitis (AD). Working Hypothesis To assess whether prenatal/postnatal exposure to air pollutants triggers new‐onset asthma development in childre...
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| Veröffentlicht in: | Pediatric pulmonology 2022-11, Vol.57 (11), p.2724-2734 |
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| container_title | Pediatric pulmonology |
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| creator | Chen, I‐Lun Chung, Hao‐Wei Hsieh, Hui‐Min Chen, Szu‐Chia Chen, Huang‐Chi Lin, Yi‐Ching Hung, Chih‐Hsing |
| description | Objectives
Air pollution is strongly associated with asthma, but has not been determined to induce new‐onset asthma development in children with atopic dermatitis (AD).
Working Hypothesis
To assess whether prenatal/postnatal exposure to air pollutants triggers new‐onset asthma development in children with AD.
Study Design
Retrospective cohort study.
Patient‐subject Selection
Data of patients 3% were significantly influenced by prenatal exposure to PM2.5, especially SO2, NO, and NO2.
Conclusions
Prenatal and postnatal exposure to air pollution have an association with asthma development in AD patients. |
| doi_str_mv | 10.1002/ppul.26089 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2725179803</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2725179803</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3579-d3f13b27c6693265c03de6304c657fba74cc3a25c82c30eee8d759ee218353843</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMotlYv_gAJeBO25mOTTY5S_IKCPbTnNc1m2ZT9MslS-u9N3epRGBiGeXiGeQG4xWiOESKPfT_Uc8KRkGdgipGUCUolPwdTkTGWcMHpBFx5v0Mo7iS-BBPKJMmkwFPwua4M7J1pVVA1VG0B-86HcTJlaXTwsCuhsi4u6noItmthLOVD1ShoW6grWxdRAPc2VFCFrrcaFsY1Kthg_TW4KFXtzc2pz8Dm5Xm9eEuWH6_vi6dloinLZFLQEtMtyTTnkhLONKKF4RSlmrOs3Kos1ZoqwrQgmiJjjCgyJo0hWFBGRUpn4H709q77GowP-a4bXBtP5iQjDMd3EY3Uw0hp13nvTJn3zjbKHXKM8mOY-THM_CfMCN-dlMO2McUf-pteBPAI7G1tDv-o8tVqsxyl33E-f9E</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2725179803</pqid></control><display><type>article</type><title>The prenatal and postnatal effects of air pollution on asthma in children with atopic dermatitis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Chen, I‐Lun ; Chung, Hao‐Wei ; Hsieh, Hui‐Min ; Chen, Szu‐Chia ; Chen, Huang‐Chi ; Lin, Yi‐Ching ; Hung, Chih‐Hsing</creator><creatorcontrib>Chen, I‐Lun ; Chung, Hao‐Wei ; Hsieh, Hui‐Min ; Chen, Szu‐Chia ; Chen, Huang‐Chi ; Lin, Yi‐Ching ; Hung, Chih‐Hsing</creatorcontrib><description>Objectives
Air pollution is strongly associated with asthma, but has not been determined to induce new‐onset asthma development in children with atopic dermatitis (AD).
Working Hypothesis
To assess whether prenatal/postnatal exposure to air pollutants triggers new‐onset asthma development in children with AD.
Study Design
Retrospective cohort study.
Patient‐subject Selection
Data of patients <age 18 years diagnosed with eczema or AD between 2009 and 2019 were extracted from the multicenter Kaohsiung Medical University Hospital Research Database. Patients diagnosed with new‐onset asthma were in the asthma group and patients without asthma history were in the non‐asthma group.
Methodology
The monthly average concentration of air pollutants for 1, 3, and 5 years before the index date, and 3, 6, and 9 months prenatally were analyzed and further stratified by age, immunoglobulin (Ig) E, and the percentage of eosinophil and eosinophil cationic protein (ECP).
Results
Postnatal exposure to airborne particulate matter (PM2.5, PM10), sulfur dioxide (SO2), ozone (O3), carbon monoxide (CO), nitric oxide (NO), nitric dioxide (NO2), and NOx, and prenatal exposure to PM2.5, PM10, SO2, NO, and NOx were significantly higher in the asthma group than in the non‐asthma group. Patients having IgE above 100 IU/ml and ECP less than 24 ng/ml were significantly influenced by postnatal exposure to PM2.5 and PM10, especially CO, to develop asthma, and those having an eosinophil count >3% were significantly influenced by prenatal exposure to PM2.5, especially SO2, NO, and NO2.
Conclusions
Prenatal and postnatal exposure to air pollution have an association with asthma development in AD patients.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.26089</identifier><identifier>PMID: 35927981</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Air Pollutants - adverse effects ; Air Pollutants - analysis ; Air pollution ; Air Pollution - adverse effects ; Air Pollution - analysis ; allergy ; Asthma ; Asthma - epidemiology ; Asthma - etiology ; atopic dermatitis ; Carbon Monoxide - adverse effects ; Child ; children ; Dermatitis ; Dermatitis, Atopic - epidemiology ; Eczema ; Environmental Exposure - adverse effects ; Environmental Exposure - analysis ; Eosinophil Cationic Protein ; Female ; Humans ; Immunoglobulin E ; Nitric Oxide ; Nitrogen Dioxide - adverse effects ; Nitrogen Dioxide - analysis ; Ozone - adverse effects ; Ozone - analysis ; Particulate Matter - adverse effects ; Particulate Matter - analysis ; Pollutants ; Pregnancy ; Prenatal exposure ; Prenatal Exposure Delayed Effects ; prenatal/postnatal exposure ; Retrospective Studies ; Sulfur Dioxide - adverse effects ; Sulfur Dioxide - analysis</subject><ispartof>Pediatric pulmonology, 2022-11, Vol.57 (11), p.2724-2734</ispartof><rights>2022 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3579-d3f13b27c6693265c03de6304c657fba74cc3a25c82c30eee8d759ee218353843</citedby><cites>FETCH-LOGICAL-c3579-d3f13b27c6693265c03de6304c657fba74cc3a25c82c30eee8d759ee218353843</cites><orcidid>0000-0002-2026-5108</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fppul.26089$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fppul.26089$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35927981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, I‐Lun</creatorcontrib><creatorcontrib>Chung, Hao‐Wei</creatorcontrib><creatorcontrib>Hsieh, Hui‐Min</creatorcontrib><creatorcontrib>Chen, Szu‐Chia</creatorcontrib><creatorcontrib>Chen, Huang‐Chi</creatorcontrib><creatorcontrib>Lin, Yi‐Ching</creatorcontrib><creatorcontrib>Hung, Chih‐Hsing</creatorcontrib><title>The prenatal and postnatal effects of air pollution on asthma in children with atopic dermatitis</title><title>Pediatric pulmonology</title><addtitle>Pediatr Pulmonol</addtitle><description>Objectives
Air pollution is strongly associated with asthma, but has not been determined to induce new‐onset asthma development in children with atopic dermatitis (AD).
Working Hypothesis
To assess whether prenatal/postnatal exposure to air pollutants triggers new‐onset asthma development in children with AD.
Study Design
Retrospective cohort study.
Patient‐subject Selection
Data of patients <age 18 years diagnosed with eczema or AD between 2009 and 2019 were extracted from the multicenter Kaohsiung Medical University Hospital Research Database. Patients diagnosed with new‐onset asthma were in the asthma group and patients without asthma history were in the non‐asthma group.
Methodology
The monthly average concentration of air pollutants for 1, 3, and 5 years before the index date, and 3, 6, and 9 months prenatally were analyzed and further stratified by age, immunoglobulin (Ig) E, and the percentage of eosinophil and eosinophil cationic protein (ECP).
Results
Postnatal exposure to airborne particulate matter (PM2.5, PM10), sulfur dioxide (SO2), ozone (O3), carbon monoxide (CO), nitric oxide (NO), nitric dioxide (NO2), and NOx, and prenatal exposure to PM2.5, PM10, SO2, NO, and NOx were significantly higher in the asthma group than in the non‐asthma group. Patients having IgE above 100 IU/ml and ECP less than 24 ng/ml were significantly influenced by postnatal exposure to PM2.5 and PM10, especially CO, to develop asthma, and those having an eosinophil count >3% were significantly influenced by prenatal exposure to PM2.5, especially SO2, NO, and NO2.
Conclusions
Prenatal and postnatal exposure to air pollution have an association with asthma development in AD patients.</description><subject>Adolescent</subject><subject>Air Pollutants - adverse effects</subject><subject>Air Pollutants - analysis</subject><subject>Air pollution</subject><subject>Air Pollution - adverse effects</subject><subject>Air Pollution - analysis</subject><subject>allergy</subject><subject>Asthma</subject><subject>Asthma - epidemiology</subject><subject>Asthma - etiology</subject><subject>atopic dermatitis</subject><subject>Carbon Monoxide - adverse effects</subject><subject>Child</subject><subject>children</subject><subject>Dermatitis</subject><subject>Dermatitis, Atopic - epidemiology</subject><subject>Eczema</subject><subject>Environmental Exposure - adverse effects</subject><subject>Environmental Exposure - analysis</subject><subject>Eosinophil Cationic Protein</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin E</subject><subject>Nitric Oxide</subject><subject>Nitrogen Dioxide - adverse effects</subject><subject>Nitrogen Dioxide - analysis</subject><subject>Ozone - adverse effects</subject><subject>Ozone - analysis</subject><subject>Particulate Matter - adverse effects</subject><subject>Particulate Matter - analysis</subject><subject>Pollutants</subject><subject>Pregnancy</subject><subject>Prenatal exposure</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>prenatal/postnatal exposure</subject><subject>Retrospective Studies</subject><subject>Sulfur Dioxide - adverse effects</subject><subject>Sulfur Dioxide - analysis</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotlYv_gAJeBO25mOTTY5S_IKCPbTnNc1m2ZT9MslS-u9N3epRGBiGeXiGeQG4xWiOESKPfT_Uc8KRkGdgipGUCUolPwdTkTGWcMHpBFx5v0Mo7iS-BBPKJMmkwFPwua4M7J1pVVA1VG0B-86HcTJlaXTwsCuhsi4u6noItmthLOVD1ShoW6grWxdRAPc2VFCFrrcaFsY1Kthg_TW4KFXtzc2pz8Dm5Xm9eEuWH6_vi6dloinLZFLQEtMtyTTnkhLONKKF4RSlmrOs3Kos1ZoqwrQgmiJjjCgyJo0hWFBGRUpn4H709q77GowP-a4bXBtP5iQjDMd3EY3Uw0hp13nvTJn3zjbKHXKM8mOY-THM_CfMCN-dlMO2McUf-pteBPAI7G1tDv-o8tVqsxyl33E-f9E</recordid><startdate>202211</startdate><enddate>202211</enddate><creator>Chen, I‐Lun</creator><creator>Chung, Hao‐Wei</creator><creator>Hsieh, Hui‐Min</creator><creator>Chen, Szu‐Chia</creator><creator>Chen, Huang‐Chi</creator><creator>Lin, Yi‐Ching</creator><creator>Hung, Chih‐Hsing</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0002-2026-5108</orcidid></search><sort><creationdate>202211</creationdate><title>The prenatal and postnatal effects of air pollution on asthma in children with atopic dermatitis</title><author>Chen, I‐Lun ; Chung, Hao‐Wei ; Hsieh, Hui‐Min ; Chen, Szu‐Chia ; Chen, Huang‐Chi ; Lin, Yi‐Ching ; Hung, Chih‐Hsing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3579-d3f13b27c6693265c03de6304c657fba74cc3a25c82c30eee8d759ee218353843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adolescent</topic><topic>Air Pollutants - adverse effects</topic><topic>Air Pollutants - analysis</topic><topic>Air pollution</topic><topic>Air Pollution - adverse effects</topic><topic>Air Pollution - analysis</topic><topic>allergy</topic><topic>Asthma</topic><topic>Asthma - epidemiology</topic><topic>Asthma - etiology</topic><topic>atopic dermatitis</topic><topic>Carbon Monoxide - adverse effects</topic><topic>Child</topic><topic>children</topic><topic>Dermatitis</topic><topic>Dermatitis, Atopic - epidemiology</topic><topic>Eczema</topic><topic>Environmental Exposure - adverse effects</topic><topic>Environmental Exposure - analysis</topic><topic>Eosinophil Cationic Protein</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin E</topic><topic>Nitric Oxide</topic><topic>Nitrogen Dioxide - adverse effects</topic><topic>Nitrogen Dioxide - analysis</topic><topic>Ozone - adverse effects</topic><topic>Ozone - analysis</topic><topic>Particulate Matter - adverse effects</topic><topic>Particulate Matter - analysis</topic><topic>Pollutants</topic><topic>Pregnancy</topic><topic>Prenatal exposure</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>prenatal/postnatal exposure</topic><topic>Retrospective Studies</topic><topic>Sulfur Dioxide - adverse effects</topic><topic>Sulfur Dioxide - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, I‐Lun</creatorcontrib><creatorcontrib>Chung, Hao‐Wei</creatorcontrib><creatorcontrib>Hsieh, Hui‐Min</creatorcontrib><creatorcontrib>Chen, Szu‐Chia</creatorcontrib><creatorcontrib>Chen, Huang‐Chi</creatorcontrib><creatorcontrib>Lin, Yi‐Ching</creatorcontrib><creatorcontrib>Hung, Chih‐Hsing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, I‐Lun</au><au>Chung, Hao‐Wei</au><au>Hsieh, Hui‐Min</au><au>Chen, Szu‐Chia</au><au>Chen, Huang‐Chi</au><au>Lin, Yi‐Ching</au><au>Hung, Chih‐Hsing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prenatal and postnatal effects of air pollution on asthma in children with atopic dermatitis</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr Pulmonol</addtitle><date>2022-11</date><risdate>2022</risdate><volume>57</volume><issue>11</issue><spage>2724</spage><epage>2734</epage><pages>2724-2734</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><abstract>Objectives
Air pollution is strongly associated with asthma, but has not been determined to induce new‐onset asthma development in children with atopic dermatitis (AD).
Working Hypothesis
To assess whether prenatal/postnatal exposure to air pollutants triggers new‐onset asthma development in children with AD.
Study Design
Retrospective cohort study.
Patient‐subject Selection
Data of patients <age 18 years diagnosed with eczema or AD between 2009 and 2019 were extracted from the multicenter Kaohsiung Medical University Hospital Research Database. Patients diagnosed with new‐onset asthma were in the asthma group and patients without asthma history were in the non‐asthma group.
Methodology
The monthly average concentration of air pollutants for 1, 3, and 5 years before the index date, and 3, 6, and 9 months prenatally were analyzed and further stratified by age, immunoglobulin (Ig) E, and the percentage of eosinophil and eosinophil cationic protein (ECP).
Results
Postnatal exposure to airborne particulate matter (PM2.5, PM10), sulfur dioxide (SO2), ozone (O3), carbon monoxide (CO), nitric oxide (NO), nitric dioxide (NO2), and NOx, and prenatal exposure to PM2.5, PM10, SO2, NO, and NOx were significantly higher in the asthma group than in the non‐asthma group. Patients having IgE above 100 IU/ml and ECP less than 24 ng/ml were significantly influenced by postnatal exposure to PM2.5 and PM10, especially CO, to develop asthma, and those having an eosinophil count >3% were significantly influenced by prenatal exposure to PM2.5, especially SO2, NO, and NO2.
Conclusions
Prenatal and postnatal exposure to air pollution have an association with asthma development in AD patients.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>35927981</pmid><doi>10.1002/ppul.26089</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-2026-5108</orcidid></addata></record> |
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| ispartof | Pediatric pulmonology, 2022-11, Vol.57 (11), p.2724-2734 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Air Pollutants - adverse effects Air Pollutants - analysis Air pollution Air Pollution - adverse effects Air Pollution - analysis allergy Asthma Asthma - epidemiology Asthma - etiology atopic dermatitis Carbon Monoxide - adverse effects Child children Dermatitis Dermatitis, Atopic - epidemiology Eczema Environmental Exposure - adverse effects Environmental Exposure - analysis Eosinophil Cationic Protein Female Humans Immunoglobulin E Nitric Oxide Nitrogen Dioxide - adverse effects Nitrogen Dioxide - analysis Ozone - adverse effects Ozone - analysis Particulate Matter - adverse effects Particulate Matter - analysis Pollutants Pregnancy Prenatal exposure Prenatal Exposure Delayed Effects prenatal/postnatal exposure Retrospective Studies Sulfur Dioxide - adverse effects Sulfur Dioxide - analysis |
| title | The prenatal and postnatal effects of air pollution on asthma in children with atopic dermatitis |
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