Long‐term delivery of etanercept mediated via a thermosensitive hydrogel for efficient inhibition of wear debris‐induced inflammatory osteolysis

Periprosthetic wear debris‐induced aseptic loosening brings great pain to patients undergoing total joint arthroplasty. Tumor necrosis factor α (TNF‐α) is a pivotal cytokine involved in wear debris‐induced aseptic inflammation and subsequent osteolysis. Herein, we developed an injectable hydrogel sy...

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Veröffentlicht in:Journal of polymer science (2020) 2022-10, Vol.60 (20), p.2875-2888
Hauptverfasser: Lei, Kewen, Wang, Yang, Peng, Xiaochun, Yu, Lin, Ding, Jiandong
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Sprache:eng
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