Synthesis, characterization, biological properties, and molecular docking studies of new phosphoramide-based Ag() complexes
Two new Ag( i ) complexes of N -( n -pyridinyl)diphenylphosphinic amide ( n = 2 and 3) ( L o and L m ) with formulae Ag( L o )NO 3 ( C o ) and Ag( L m )NO 3 ·H 2 O ( C m ) were synthesized. Infrared, NMR, and elemental analyses were applied to fully characterize them. The crystal structure of C m wa...
Gespeichert in:
| Veröffentlicht in: | New journal of chemistry 2022-10, Vol.46 (38), p.18326-18335 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 18335 |
|---|---|
| container_issue | 38 |
| container_start_page | 18326 |
| container_title | New journal of chemistry |
| container_volume | 46 |
| creator | Gholivand, Khodayar Faraghi, Mohammad Tizhoush, Samaneh K Ahmadi, Sara Yousefian, Mostafa Mohammadpanah, Fahimeh Roe, S. Mark |
| description | Two new Ag(
i
) complexes of
N
-(
n
-pyridinyl)diphenylphosphinic amide (
n
= 2 and 3) (
L
o
and
L
m
) with formulae Ag(
L
o
)NO
3
(
C
o
) and Ag(
L
m
)NO
3
·H
2
O (
C
m
) were synthesized. Infrared, NMR, and elemental analyses were applied to fully characterize them. The crystal structure of
C
m
was also assessed using single-crystal X-ray diffraction and the monoclinic nature of the silver complex was illustrated. The organization of four coordinated dinuclear Ag(
i
) complexes and intermolecular interactions were also studied. The supramolecule was formed by the cooperation of various intermolecular interactions, hydrogen bonds, M π, π π contacts, and CH π synthons. Antibacterial studies of Ag(
i
) complexes and the corresponding ligands against Gram-negative (
Escherichia coli
) and Gram-positive bacteria (
Staphylococcus aureus
) were carried out by MIC, MBC, and DDA methods and
C
m
showed more bactericidal activity than
C
o
against both bacteria (
E. coli
; MIC = 9.7 μg mL
−1
and
S. aureus
; MIC = 78 μg mL
−1
). The potential antitumor activity of
C
o
and
C
m
was also evaluated for human colon cancer cell lines (SW480) through anticancer (MTT and apoptosis) experiments, and it was revealed that
C
m
has the most toxicity (IC
50
= 39.6 μg mL
−1
) by an MTT assay. An initial evaluation of the mechanism of cell death induced by
C
o
and
C
m
was performed. Cell death was mainly from the activation of apoptosis processes. The results were further examined by docking studies to confirm that
C
m
has the potency to be a good candidate for biological applications.
The effect of two new synthesized Ag(
i
) complexes on their biological properties was examined. |
| doi_str_mv | 10.1039/d2nj02748h |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_rsc_p</sourceid><recordid>TN_cdi_proquest_journals_2720373513</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2720373513</sourcerecordid><originalsourceid>FETCH-LOGICAL-c240t-2d5770f75fa3b3fdf4006fe0d01b06cafea4523ff838c2f33bdb5956a26ae6ae3</originalsourceid><addsrcrecordid>eNpFkEtLAzEQgIMoWKsX70LAi0pX89hHeyz1UaXoQT0v2WTSTd3drMkuWv3zRisKM8zAfMwwH0KHlJxTwicXijUrwrJ4XG6hAeXpJJqwlG6HnsZxRJI43UV73q8IoTRL6QB9Pq6brgRv_AjLUjghO3DmQ3TGNiNcGFvZpZGiwq2zLbjOQABFo3BtK5B9JRxWVr6YZol916swxlbjBt5wW1of0onaKIgK4UHh6fLkFEtbtxW8g99HO1pUHg5-6xA9X189zebR4uHmdjZdRJLFpIuYSrKM6CzRghdcKx0TkmogitCCpFJoEHHCuNZjPpZMc16oIpkkqWCpgBB8iI43e8MPrz34Ll_Z3jXhZM4yRnjGE8oDdbahpLPeO9B560wt3DqnJP-Wm1-y-7sfufMAH21g5-Uf9y-ffwHvx3kh</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2720373513</pqid></control><display><type>article</type><title>Synthesis, characterization, biological properties, and molecular docking studies of new phosphoramide-based Ag() complexes</title><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Gholivand, Khodayar ; Faraghi, Mohammad ; Tizhoush, Samaneh K ; Ahmadi, Sara ; Yousefian, Mostafa ; Mohammadpanah, Fahimeh ; Roe, S. Mark</creator><creatorcontrib>Gholivand, Khodayar ; Faraghi, Mohammad ; Tizhoush, Samaneh K ; Ahmadi, Sara ; Yousefian, Mostafa ; Mohammadpanah, Fahimeh ; Roe, S. Mark</creatorcontrib><description>Two new Ag(
i
) complexes of
N
-(
n
-pyridinyl)diphenylphosphinic amide (
n
= 2 and 3) (
L
o
and
L
m
) with formulae Ag(
L
o
)NO
3
(
C
o
) and Ag(
L
m
)NO
3
·H
2
O (
C
m
) were synthesized. Infrared, NMR, and elemental analyses were applied to fully characterize them. The crystal structure of
C
m
was also assessed using single-crystal X-ray diffraction and the monoclinic nature of the silver complex was illustrated. The organization of four coordinated dinuclear Ag(
i
) complexes and intermolecular interactions were also studied. The supramolecule was formed by the cooperation of various intermolecular interactions, hydrogen bonds, M π, π π contacts, and CH π synthons. Antibacterial studies of Ag(
i
) complexes and the corresponding ligands against Gram-negative (
Escherichia coli
) and Gram-positive bacteria (
Staphylococcus aureus
) were carried out by MIC, MBC, and DDA methods and
C
m
showed more bactericidal activity than
C
o
against both bacteria (
E. coli
; MIC = 9.7 μg mL
−1
and
S. aureus
; MIC = 78 μg mL
−1
). The potential antitumor activity of
C
o
and
C
m
was also evaluated for human colon cancer cell lines (SW480) through anticancer (MTT and apoptosis) experiments, and it was revealed that
C
m
has the most toxicity (IC
50
= 39.6 μg mL
−1
) by an MTT assay. An initial evaluation of the mechanism of cell death induced by
C
o
and
C
m
was performed. Cell death was mainly from the activation of apoptosis processes. The results were further examined by docking studies to confirm that
C
m
has the potency to be a good candidate for biological applications.
The effect of two new synthesized Ag(
i
) complexes on their biological properties was examined.</description><identifier>ISSN: 1144-0546</identifier><identifier>EISSN: 1369-9261</identifier><identifier>DOI: 10.1039/d2nj02748h</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Anticancer properties ; Antiinfectives and antibacterials ; Apoptosis ; Biological properties ; Cell death ; Chemical synthesis ; Cobalt ; Coliforms ; Colon ; Crystal structure ; E coli ; Evaluation ; Gram-positive bacteria ; Hydrogen bonds ; Infrared analysis ; Molecular docking ; NMR ; Nuclear magnetic resonance ; Silver compounds ; Single crystals ; Toxicity</subject><ispartof>New journal of chemistry, 2022-10, Vol.46 (38), p.18326-18335</ispartof><rights>Copyright Royal Society of Chemistry 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c240t-2d5770f75fa3b3fdf4006fe0d01b06cafea4523ff838c2f33bdb5956a26ae6ae3</cites><orcidid>0000-0001-8884-7895 ; 0000-0003-1789-1025 ; 0000-0001-8043-1799</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids></links><search><creatorcontrib>Gholivand, Khodayar</creatorcontrib><creatorcontrib>Faraghi, Mohammad</creatorcontrib><creatorcontrib>Tizhoush, Samaneh K</creatorcontrib><creatorcontrib>Ahmadi, Sara</creatorcontrib><creatorcontrib>Yousefian, Mostafa</creatorcontrib><creatorcontrib>Mohammadpanah, Fahimeh</creatorcontrib><creatorcontrib>Roe, S. Mark</creatorcontrib><title>Synthesis, characterization, biological properties, and molecular docking studies of new phosphoramide-based Ag() complexes</title><title>New journal of chemistry</title><description>Two new Ag(
i
) complexes of
N
-(
n
-pyridinyl)diphenylphosphinic amide (
n
= 2 and 3) (
L
o
and
L
m
) with formulae Ag(
L
o
)NO
3
(
C
o
) and Ag(
L
m
)NO
3
·H
2
O (
C
m
) were synthesized. Infrared, NMR, and elemental analyses were applied to fully characterize them. The crystal structure of
C
m
was also assessed using single-crystal X-ray diffraction and the monoclinic nature of the silver complex was illustrated. The organization of four coordinated dinuclear Ag(
i
) complexes and intermolecular interactions were also studied. The supramolecule was formed by the cooperation of various intermolecular interactions, hydrogen bonds, M π, π π contacts, and CH π synthons. Antibacterial studies of Ag(
i
) complexes and the corresponding ligands against Gram-negative (
Escherichia coli
) and Gram-positive bacteria (
Staphylococcus aureus
) were carried out by MIC, MBC, and DDA methods and
C
m
showed more bactericidal activity than
C
o
against both bacteria (
E. coli
; MIC = 9.7 μg mL
−1
and
S. aureus
; MIC = 78 μg mL
−1
). The potential antitumor activity of
C
o
and
C
m
was also evaluated for human colon cancer cell lines (SW480) through anticancer (MTT and apoptosis) experiments, and it was revealed that
C
m
has the most toxicity (IC
50
= 39.6 μg mL
−1
) by an MTT assay. An initial evaluation of the mechanism of cell death induced by
C
o
and
C
m
was performed. Cell death was mainly from the activation of apoptosis processes. The results were further examined by docking studies to confirm that
C
m
has the potency to be a good candidate for biological applications.
The effect of two new synthesized Ag(
i
) complexes on their biological properties was examined.</description><subject>Anticancer properties</subject><subject>Antiinfectives and antibacterials</subject><subject>Apoptosis</subject><subject>Biological properties</subject><subject>Cell death</subject><subject>Chemical synthesis</subject><subject>Cobalt</subject><subject>Coliforms</subject><subject>Colon</subject><subject>Crystal structure</subject><subject>E coli</subject><subject>Evaluation</subject><subject>Gram-positive bacteria</subject><subject>Hydrogen bonds</subject><subject>Infrared analysis</subject><subject>Molecular docking</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Silver compounds</subject><subject>Single crystals</subject><subject>Toxicity</subject><issn>1144-0546</issn><issn>1369-9261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpFkEtLAzEQgIMoWKsX70LAi0pX89hHeyz1UaXoQT0v2WTSTd3drMkuWv3zRisKM8zAfMwwH0KHlJxTwicXijUrwrJ4XG6hAeXpJJqwlG6HnsZxRJI43UV73q8IoTRL6QB9Pq6brgRv_AjLUjghO3DmQ3TGNiNcGFvZpZGiwq2zLbjOQABFo3BtK5B9JRxWVr6YZol916swxlbjBt5wW1of0onaKIgK4UHh6fLkFEtbtxW8g99HO1pUHg5-6xA9X189zebR4uHmdjZdRJLFpIuYSrKM6CzRghdcKx0TkmogitCCpFJoEHHCuNZjPpZMc16oIpkkqWCpgBB8iI43e8MPrz34Ll_Z3jXhZM4yRnjGE8oDdbahpLPeO9B560wt3DqnJP-Wm1-y-7sfufMAH21g5-Uf9y-ffwHvx3kh</recordid><startdate>20221003</startdate><enddate>20221003</enddate><creator>Gholivand, Khodayar</creator><creator>Faraghi, Mohammad</creator><creator>Tizhoush, Samaneh K</creator><creator>Ahmadi, Sara</creator><creator>Yousefian, Mostafa</creator><creator>Mohammadpanah, Fahimeh</creator><creator>Roe, S. Mark</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>H9R</scope><scope>JG9</scope><scope>KA0</scope><orcidid>https://orcid.org/0000-0001-8884-7895</orcidid><orcidid>https://orcid.org/0000-0003-1789-1025</orcidid><orcidid>https://orcid.org/0000-0001-8043-1799</orcidid></search><sort><creationdate>20221003</creationdate><title>Synthesis, characterization, biological properties, and molecular docking studies of new phosphoramide-based Ag() complexes</title><author>Gholivand, Khodayar ; Faraghi, Mohammad ; Tizhoush, Samaneh K ; Ahmadi, Sara ; Yousefian, Mostafa ; Mohammadpanah, Fahimeh ; Roe, S. Mark</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c240t-2d5770f75fa3b3fdf4006fe0d01b06cafea4523ff838c2f33bdb5956a26ae6ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anticancer properties</topic><topic>Antiinfectives and antibacterials</topic><topic>Apoptosis</topic><topic>Biological properties</topic><topic>Cell death</topic><topic>Chemical synthesis</topic><topic>Cobalt</topic><topic>Coliforms</topic><topic>Colon</topic><topic>Crystal structure</topic><topic>E coli</topic><topic>Evaluation</topic><topic>Gram-positive bacteria</topic><topic>Hydrogen bonds</topic><topic>Infrared analysis</topic><topic>Molecular docking</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Silver compounds</topic><topic>Single crystals</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gholivand, Khodayar</creatorcontrib><creatorcontrib>Faraghi, Mohammad</creatorcontrib><creatorcontrib>Tizhoush, Samaneh K</creatorcontrib><creatorcontrib>Ahmadi, Sara</creatorcontrib><creatorcontrib>Yousefian, Mostafa</creatorcontrib><creatorcontrib>Mohammadpanah, Fahimeh</creatorcontrib><creatorcontrib>Roe, S. Mark</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Illustrata: Natural Sciences</collection><collection>Materials Research Database</collection><collection>ProQuest Illustrata: Technology Collection</collection><jtitle>New journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gholivand, Khodayar</au><au>Faraghi, Mohammad</au><au>Tizhoush, Samaneh K</au><au>Ahmadi, Sara</au><au>Yousefian, Mostafa</au><au>Mohammadpanah, Fahimeh</au><au>Roe, S. Mark</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, characterization, biological properties, and molecular docking studies of new phosphoramide-based Ag() complexes</atitle><jtitle>New journal of chemistry</jtitle><date>2022-10-03</date><risdate>2022</risdate><volume>46</volume><issue>38</issue><spage>18326</spage><epage>18335</epage><pages>18326-18335</pages><issn>1144-0546</issn><eissn>1369-9261</eissn><abstract>Two new Ag(
i
) complexes of
N
-(
n
-pyridinyl)diphenylphosphinic amide (
n
= 2 and 3) (
L
o
and
L
m
) with formulae Ag(
L
o
)NO
3
(
C
o
) and Ag(
L
m
)NO
3
·H
2
O (
C
m
) were synthesized. Infrared, NMR, and elemental analyses were applied to fully characterize them. The crystal structure of
C
m
was also assessed using single-crystal X-ray diffraction and the monoclinic nature of the silver complex was illustrated. The organization of four coordinated dinuclear Ag(
i
) complexes and intermolecular interactions were also studied. The supramolecule was formed by the cooperation of various intermolecular interactions, hydrogen bonds, M π, π π contacts, and CH π synthons. Antibacterial studies of Ag(
i
) complexes and the corresponding ligands against Gram-negative (
Escherichia coli
) and Gram-positive bacteria (
Staphylococcus aureus
) were carried out by MIC, MBC, and DDA methods and
C
m
showed more bactericidal activity than
C
o
against both bacteria (
E. coli
; MIC = 9.7 μg mL
−1
and
S. aureus
; MIC = 78 μg mL
−1
). The potential antitumor activity of
C
o
and
C
m
was also evaluated for human colon cancer cell lines (SW480) through anticancer (MTT and apoptosis) experiments, and it was revealed that
C
m
has the most toxicity (IC
50
= 39.6 μg mL
−1
) by an MTT assay. An initial evaluation of the mechanism of cell death induced by
C
o
and
C
m
was performed. Cell death was mainly from the activation of apoptosis processes. The results were further examined by docking studies to confirm that
C
m
has the potency to be a good candidate for biological applications.
The effect of two new synthesized Ag(
i
) complexes on their biological properties was examined.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/d2nj02748h</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-8884-7895</orcidid><orcidid>https://orcid.org/0000-0003-1789-1025</orcidid><orcidid>https://orcid.org/0000-0001-8043-1799</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1144-0546 |
| ispartof | New journal of chemistry, 2022-10, Vol.46 (38), p.18326-18335 |
| issn | 1144-0546 1369-9261 |
| language | eng |
| recordid | cdi_proquest_journals_2720373513 |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Anticancer properties Antiinfectives and antibacterials Apoptosis Biological properties Cell death Chemical synthesis Cobalt Coliforms Colon Crystal structure E coli Evaluation Gram-positive bacteria Hydrogen bonds Infrared analysis Molecular docking NMR Nuclear magnetic resonance Silver compounds Single crystals Toxicity |
| title | Synthesis, characterization, biological properties, and molecular docking studies of new phosphoramide-based Ag() complexes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T16%3A28%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_rsc_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthesis,%20characterization,%20biological%20properties,%20and%20molecular%20docking%20studies%20of%20new%20phosphoramide-based%20Ag()%20complexes&rft.jtitle=New%20journal%20of%20chemistry&rft.au=Gholivand,%20Khodayar&rft.date=2022-10-03&rft.volume=46&rft.issue=38&rft.spage=18326&rft.epage=18335&rft.pages=18326-18335&rft.issn=1144-0546&rft.eissn=1369-9261&rft_id=info:doi/10.1039/d2nj02748h&rft_dat=%3Cproquest_rsc_p%3E2720373513%3C/proquest_rsc_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2720373513&rft_id=info:pmid/&rfr_iscdi=true |