Overexpression of nucleotide metabolic enzyme DUT in hepatocellular carcinoma potentiates a therapeutic opportunity through targeting its dUTPase activity

Uracil misincorporation during DNA replication is a major cell toxic event, of which cancer cells overcome by activating the dUTPase enzyme. The DUT gene is the only known dUTPase in human. Despite reports on common upregulations in cancers, the role of DUT in human hepatocellular carcinoma (HCC) re...

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Veröffentlicht in:	Cancer letters 2022-11, Vol.548, p.215898, Article 215898
Hauptverfasser:	Xu, Mingjing, Liu, Yue, Wan, Ho Lee, Wong, Alissa M, Ding, Xiaofan, You, Wenxing, Lo, Wing Sze, Ng, Kelvin K-C, Wong, Nathalie
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Cell cycle Cell death Cell Line, Tumor DNA biosynthesis DNA damage Drug resistance dUTP pyrophosphatase Enzymes Gene expression Genomes Hepatocellular carcinoma Humans Kinases Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - genetics Medical research Metabolism NF-kappa B NF-κB protein Nucleotides Organoids Oxidative stress Patients Plasmids Pyrophosphatases Sorafenib - pharmacology Transcription factors Transcriptomes Tumors Uracil Uracil - metabolism
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