Liquid Chromatographic Determination of pKa Value of 1- (2-methylbenzonitrile)-3-benzylbenzimidazolium bromide as a Drug Candidate in Acetonitrile-Water Binary Mixtures

The ionization/protonation (pKa) constant, which is a physicochemical parameter that directly affects the pharmacokinetic properties of a drug such as absorption, distribution, metabolism, and excretion (ADME), is currently determined by analytical methods. The effect of pH of the mobile phase on th...

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Veröffentlicht in:	Journal of Research in Pharmacy 2022, Vol.26(3) (26(3)), p.655-662
Hauptverfasser:	KONÇE, İlkay, AKKOÇ, Senem, ÜSTÜN, Zehra, DEMİRALAY, Ebru ÇUBUK
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography Ions
Online-Zugang:	Volltext
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