Atomic‐Scale View of Protein‐PEG Interactions that Redirect the Thermal Unfolding Pathway of PEGylated Human Galectin‐3

PEGylation is a promising approach to address the central challenge of applying biologics, i.e., lack of protein stability in the demanding environment of the human body. Wider application is hindered by lack of atomic level understanding of protein‐PEG interactions, preventing design of conjugates...

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Veröffentlicht in:	Angewandte Chemie 2022-10, Vol.134 (40), p.n/a
Hauptverfasser:	Pritzlaff, Amanda, Ferré, Guillaume, Mulry, Emma, Lin, Ling, Gopal Pour, Niloofar, Savin, Daniel A., Harris, Michael E., Eddy, Matthew T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biologics Carbohydrates Cell adhesion Chemistry Conjugates Localization NMR NMR Spectroscopy Nuclear magnetic resonance PEGylated Proteins Protein Engineering Protein-Polymer Conjugate Proteins Residues Thermal stability
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