Structural diversity and biological relevance of benzenoid and atypical ansamycins and their congeners
Covering: 2011 to 2021 The structural division of ansamycins, including those of atypical cores and different lengths of the ansa chains, is presented. Recently discovered benzenoid and atypical ansamycin scaffolds are presented in relation to their natural source and biosynthetic routes realized in...
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Veröffentlicht in: | Natural product reports 2022-09, Vol.39 (9), p.1678-174 |
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creator | Skrzypczak, Natalia Przybylski, Piotr |
description | Covering: 2011 to 2021
The structural division of ansamycins, including those of atypical cores and different lengths of the ansa chains, is presented. Recently discovered benzenoid and atypical ansamycin scaffolds are presented in relation to their natural source and biosynthetic routes realized in bacteria as well as their muta and semisynthetic modifications influencing biological properties. To better understand the structure-activity relationships among benzenoid ansamycins structural aspects together with mechanisms of action regarding different targets in cells, are discussed. The most promising directions for structural optimizations of benzenoid ansamycins, characterized by predominant anticancer properties, were discussed in view of their potential medical and pharmaceutical applications. The bibliography of the review covers mainly years from 2011 to 2021.
Origin, division, and key structural aspects for biological functionality of ansamycins are discussed. Semisynthetic, mutasynthetic and hybrid approaches, yielding new macrolactams, along their mechanism of action and biological potency are compared. |
doi_str_mv | 10.1039/d2np00004k |
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The structural division of ansamycins, including those of atypical cores and different lengths of the ansa chains, is presented. Recently discovered benzenoid and atypical ansamycin scaffolds are presented in relation to their natural source and biosynthetic routes realized in bacteria as well as their muta and semisynthetic modifications influencing biological properties. To better understand the structure-activity relationships among benzenoid ansamycins structural aspects together with mechanisms of action regarding different targets in cells, are discussed. The most promising directions for structural optimizations of benzenoid ansamycins, characterized by predominant anticancer properties, were discussed in view of their potential medical and pharmaceutical applications. The bibliography of the review covers mainly years from 2011 to 2021.
Origin, division, and key structural aspects for biological functionality of ansamycins are discussed. Semisynthetic, mutasynthetic and hybrid approaches, yielding new macrolactams, along their mechanism of action and biological potency are compared.</description><identifier>ISSN: 0265-0568</identifier><identifier>EISSN: 1460-4752</identifier><identifier>DOI: 10.1039/d2np00004k</identifier><identifier>PMID: 35262153</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Ansamycins ; Anticancer properties ; Biodiversity ; Biological properties ; Congeners</subject><ispartof>Natural product reports, 2022-09, Vol.39 (9), p.1678-174</ispartof><rights>Copyright Royal Society of Chemistry 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c303t-6dc4531ce25aae19b7a6d6846d590fb945bff749dad6e24ee1918aafbd2a01703</citedby><cites>FETCH-LOGICAL-c303t-6dc4531ce25aae19b7a6d6846d590fb945bff749dad6e24ee1918aafbd2a01703</cites><orcidid>0000-0001-8072-5877</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35262153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Skrzypczak, Natalia</creatorcontrib><creatorcontrib>Przybylski, Piotr</creatorcontrib><title>Structural diversity and biological relevance of benzenoid and atypical ansamycins and their congeners</title><title>Natural product reports</title><addtitle>Nat Prod Rep</addtitle><description>Covering: 2011 to 2021
The structural division of ansamycins, including those of atypical cores and different lengths of the ansa chains, is presented. Recently discovered benzenoid and atypical ansamycin scaffolds are presented in relation to their natural source and biosynthetic routes realized in bacteria as well as their muta and semisynthetic modifications influencing biological properties. To better understand the structure-activity relationships among benzenoid ansamycins structural aspects together with mechanisms of action regarding different targets in cells, are discussed. The most promising directions for structural optimizations of benzenoid ansamycins, characterized by predominant anticancer properties, were discussed in view of their potential medical and pharmaceutical applications. The bibliography of the review covers mainly years from 2011 to 2021.
Origin, division, and key structural aspects for biological functionality of ansamycins are discussed. Semisynthetic, mutasynthetic and hybrid approaches, yielding new macrolactams, along their mechanism of action and biological potency are compared.</description><subject>Ansamycins</subject><subject>Anticancer properties</subject><subject>Biodiversity</subject><subject>Biological properties</subject><subject>Congeners</subject><issn>0265-0568</issn><issn>1460-4752</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpd0UtLxDAUBeAgio6PjXul4EaEat5tlzI-UVRQ1yVNbjXaScakFcZfb5zxAWYTyP04hHMR2ib4kGBWHRnqpjgd_rqERoRLnPNC0GU0wlSKHAtZrqH1GF8wJqSQchWtMUElJYKNUHvfh0H3Q1BdZuw7hGj7WaacyRrrO_9kdRoE6OBdOQ2Zb7MG3Ac4b81cqX42nRvloprMtHVx_t4_gw2Z9u4JXArdRCut6iJsfd8b6PHs9GF8kV_fnl-Oj69zzTDrc2k0F4xooEIpIFVTKGlkyaURFW6bioumbQteGWUkUA6JkFKptjFUYVJgtoH2F7nT4N8GiH09sVFD1ykHfog1lawQpZCMJrr3j774Ibj0u5oWRApRFrxM6mChdPAxBmjrabATFWY1wfVX-_UJvbmbt3-V8O535NBMwPzSn7oT2FmAEPXv9G997BPwcIro</recordid><startdate>20220921</startdate><enddate>20220921</enddate><creator>Skrzypczak, Natalia</creator><creator>Przybylski, Piotr</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8072-5877</orcidid></search><sort><creationdate>20220921</creationdate><title>Structural diversity and biological relevance of benzenoid and atypical ansamycins and their congeners</title><author>Skrzypczak, Natalia ; Przybylski, Piotr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-6dc4531ce25aae19b7a6d6846d590fb945bff749dad6e24ee1918aafbd2a01703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Ansamycins</topic><topic>Anticancer properties</topic><topic>Biodiversity</topic><topic>Biological properties</topic><topic>Congeners</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Skrzypczak, Natalia</creatorcontrib><creatorcontrib>Przybylski, Piotr</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Natural product reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Skrzypczak, Natalia</au><au>Przybylski, Piotr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural diversity and biological relevance of benzenoid and atypical ansamycins and their congeners</atitle><jtitle>Natural product reports</jtitle><addtitle>Nat Prod Rep</addtitle><date>2022-09-21</date><risdate>2022</risdate><volume>39</volume><issue>9</issue><spage>1678</spage><epage>174</epage><pages>1678-174</pages><issn>0265-0568</issn><eissn>1460-4752</eissn><abstract>Covering: 2011 to 2021
The structural division of ansamycins, including those of atypical cores and different lengths of the ansa chains, is presented. Recently discovered benzenoid and atypical ansamycin scaffolds are presented in relation to their natural source and biosynthetic routes realized in bacteria as well as their muta and semisynthetic modifications influencing biological properties. To better understand the structure-activity relationships among benzenoid ansamycins structural aspects together with mechanisms of action regarding different targets in cells, are discussed. The most promising directions for structural optimizations of benzenoid ansamycins, characterized by predominant anticancer properties, were discussed in view of their potential medical and pharmaceutical applications. The bibliography of the review covers mainly years from 2011 to 2021.
Origin, division, and key structural aspects for biological functionality of ansamycins are discussed. Semisynthetic, mutasynthetic and hybrid approaches, yielding new macrolactams, along their mechanism of action and biological potency are compared.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>35262153</pmid><doi>10.1039/d2np00004k</doi><tpages>27</tpages><orcidid>https://orcid.org/0000-0001-8072-5877</orcidid><oa>free_for_read</oa></addata></record> |
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language | eng |
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source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
subjects | Ansamycins Anticancer properties Biodiversity Biological properties Congeners |
title | Structural diversity and biological relevance of benzenoid and atypical ansamycins and their congeners |
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