Targeting integrin αvβ6 with gallium-68 tris (hydroxypyridinone) based PET probes

Expression of the cellular transmembrane receptor αvβ6 integrin is mostly restricted to malignant epithelial cells in a wide variety of carcinomas, including pancreatic and others derived from epithelial tissues. Thus, this protein is considered an attractive target for tumour imaging and therapy. T...

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Veröffentlicht in:	Dalton transactions : an international journal of inorganic chemistry 2022-08, Vol.51 (34), p.12796-1283
Hauptverfasser:	Floresta, Giuseppe, Memdouh, Siham, Pham, Truc, Ma, Michelle T, Blower, Philip J, Hider, Robert C, Abbate, Vincenzo, Cilibrizzi, Agostino
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Neoplasm - metabolism Binding Chelating Agents Chelation Chemistry Epithelium Gallium isotopes Gallium Radioisotopes In vivo methods and tests Integrin alphaVbeta3 - metabolism Integrins Peptides - metabolism Positron-Emission Tomography - methods Radiochemistry Radiolabelling Receptors Tissue Distribution
Online-Zugang:	Volltext
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