Polyamidoamine dendrimer-polyethylene glycol hydrogel for solubility enhancement and sustained release of diflunisal

The purpose of this research is to develop a hydrogel delivery system for solubility enhancement and sustained release of hydrophobic drugs. The model drug, diflunisal, has documented poor solubility in water which limits its application and administration. In this research, polyamidoamine (PAMAM) d...

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Veröffentlicht in:	Journal of sol-gel science and technology 2022-10, Vol.104 (1), p.160-168
Hauptverfasser:	Kegley, Zachary, Makay, Michael, Rogers, Joshua, Phelps, Katrina, Malcom, Colleen, Hellmig, David, Kroninger, Anna, Bi, Xiangdong
Format:	Artikel
Sprache:	eng
Schlagworte:	Aqueous solutions Ceramics Chemistry and Materials Science Composites Crosslinking Drug delivery systems Encapsulation Glass Hydrogels Hydrophobicity Inorganic Chemistry Materials Science Nanotechnology Natural Materials Optical and Electronic Materials Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications Polyethylene glycol Solubility Sustained release
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