Polyamidoamine dendrimer-polyethylene glycol hydrogel for solubility enhancement and sustained release of diflunisal
The purpose of this research is to develop a hydrogel delivery system for solubility enhancement and sustained release of hydrophobic drugs. The model drug, diflunisal, has documented poor solubility in water which limits its application and administration. In this research, polyamidoamine (PAMAM) d...
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| Veröffentlicht in: | Journal of sol-gel science and technology 2022-10, Vol.104 (1), p.160-168 |
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| creator | Kegley, Zachary Makay, Michael Rogers, Joshua Phelps, Katrina Malcom, Colleen Hellmig, David Kroninger, Anna Bi, Xiangdong |
| description | The purpose of this research is to develop a hydrogel delivery system for solubility enhancement and sustained release of hydrophobic drugs. The model drug, diflunisal, has documented poor solubility in water which limits its application and administration. In this research, polyamidoamine (PAMAM) dendrimer is employed to dramatically increase the water solubility of diflunisal. In the meantime, PAMAM dendrimer functionalized with crosslinkers is further in situ crosslinked with thiolated polyethylene glycol (PEG) to form a hydrogel, encapsulating a high payload of diflunisal for sustained release. The diflunisal encapsulated hydrogel is immersed in water or laid on top of mouse skin, and the amount of diflunisal released from the gel is quantitatively measured by UV-Vis spectroscopy. Results show that the solubility of diflunisal in water is improved by 129–193 folds in the presence of PAMAM dendrimer at the experimental conditions compared to the reported solubility, and the amount of diflunisal is released by up to 87% of its load and reaches its maximum amounts after 72 h. This research demonstrates that the PAMAM dendrimer-PEG hydrogel system may serve as a promising delivery system for hydrophobic drugs.
Vinyl sulfone functionalized PAMAM dendrimer increases the water solubilty of hydrophobic anti-inflammatory drug diflunisal, and crosslinks with thiolated mutibranched PEG to form a hydrogel. A large payload of diflunisal is released from hydrogel and penetrates into mouse skin in a controllable manner depending on the hydrogel crosslinking density which can be chemically modified.
Highlights
PAMAM dendrimer-mediated hydrogel platforms with tunable structures for sustained drug delivery.
129–193-fold solubility increase of hydrophobic drug diflunisal.
74–87% drug release in 72 h either in aqueous media or through mouse skin penetration. |
| doi_str_mv | 10.1007/s10971-022-05904-y |
| format | Article |
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Vinyl sulfone functionalized PAMAM dendrimer increases the water solubilty of hydrophobic anti-inflammatory drug diflunisal, and crosslinks with thiolated mutibranched PEG to form a hydrogel. A large payload of diflunisal is released from hydrogel and penetrates into mouse skin in a controllable manner depending on the hydrogel crosslinking density which can be chemically modified.
Highlights
PAMAM dendrimer-mediated hydrogel platforms with tunable structures for sustained drug delivery.
129–193-fold solubility increase of hydrophobic drug diflunisal.
74–87% drug release in 72 h either in aqueous media or through mouse skin penetration.</description><identifier>ISSN: 0928-0707</identifier><identifier>EISSN: 1573-4846</identifier><identifier>DOI: 10.1007/s10971-022-05904-y</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aqueous solutions ; Ceramics ; Chemistry and Materials Science ; Composites ; Crosslinking ; Drug delivery systems ; Encapsulation ; Glass ; Hydrogels ; Hydrophobicity ; Inorganic Chemistry ; Materials Science ; Nanotechnology ; Natural Materials ; Optical and Electronic Materials ; Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications ; Polyethylene glycol ; Solubility ; Sustained release</subject><ispartof>Journal of sol-gel science and technology, 2022-10, Vol.104 (1), p.160-168</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c249t-22ffc45b8c3807ca896837d4ec9fa36f5eb503066d8162a200797dd1864be7643</citedby><cites>FETCH-LOGICAL-c249t-22ffc45b8c3807ca896837d4ec9fa36f5eb503066d8162a200797dd1864be7643</cites><orcidid>0000-0002-8425-8468</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10971-022-05904-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10971-022-05904-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Kegley, Zachary</creatorcontrib><creatorcontrib>Makay, Michael</creatorcontrib><creatorcontrib>Rogers, Joshua</creatorcontrib><creatorcontrib>Phelps, Katrina</creatorcontrib><creatorcontrib>Malcom, Colleen</creatorcontrib><creatorcontrib>Hellmig, David</creatorcontrib><creatorcontrib>Kroninger, Anna</creatorcontrib><creatorcontrib>Bi, Xiangdong</creatorcontrib><title>Polyamidoamine dendrimer-polyethylene glycol hydrogel for solubility enhancement and sustained release of diflunisal</title><title>Journal of sol-gel science and technology</title><addtitle>J Sol-Gel Sci Technol</addtitle><description>The purpose of this research is to develop a hydrogel delivery system for solubility enhancement and sustained release of hydrophobic drugs. The model drug, diflunisal, has documented poor solubility in water which limits its application and administration. In this research, polyamidoamine (PAMAM) dendrimer is employed to dramatically increase the water solubility of diflunisal. In the meantime, PAMAM dendrimer functionalized with crosslinkers is further in situ crosslinked with thiolated polyethylene glycol (PEG) to form a hydrogel, encapsulating a high payload of diflunisal for sustained release. The diflunisal encapsulated hydrogel is immersed in water or laid on top of mouse skin, and the amount of diflunisal released from the gel is quantitatively measured by UV-Vis spectroscopy. Results show that the solubility of diflunisal in water is improved by 129–193 folds in the presence of PAMAM dendrimer at the experimental conditions compared to the reported solubility, and the amount of diflunisal is released by up to 87% of its load and reaches its maximum amounts after 72 h. This research demonstrates that the PAMAM dendrimer-PEG hydrogel system may serve as a promising delivery system for hydrophobic drugs.
Vinyl sulfone functionalized PAMAM dendrimer increases the water solubilty of hydrophobic anti-inflammatory drug diflunisal, and crosslinks with thiolated mutibranched PEG to form a hydrogel. A large payload of diflunisal is released from hydrogel and penetrates into mouse skin in a controllable manner depending on the hydrogel crosslinking density which can be chemically modified.
Highlights
PAMAM dendrimer-mediated hydrogel platforms with tunable structures for sustained drug delivery.
129–193-fold solubility increase of hydrophobic drug diflunisal.
74–87% drug release in 72 h either in aqueous media or through mouse skin penetration.</description><subject>Aqueous solutions</subject><subject>Ceramics</subject><subject>Chemistry and Materials Science</subject><subject>Composites</subject><subject>Crosslinking</subject><subject>Drug delivery systems</subject><subject>Encapsulation</subject><subject>Glass</subject><subject>Hydrogels</subject><subject>Hydrophobicity</subject><subject>Inorganic Chemistry</subject><subject>Materials Science</subject><subject>Nanotechnology</subject><subject>Natural Materials</subject><subject>Optical and Electronic Materials</subject><subject>Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications</subject><subject>Polyethylene glycol</subject><subject>Solubility</subject><subject>Sustained release</subject><issn>0928-0707</issn><issn>1573-4846</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kE1r3DAQhkVoodtt_0BPgpyVjGRZso9haZvAQnNIz0K2RrtetNJGsg_-91W6hdx6mYGZ9wMeQr5xuOMA-r5w6DVnIASDtgfJ1huy4a1umOyk-kA20IuOgQb9iXwu5QQAreR6Q-bnFFZ7nlyqIyJ1GF2ezpjZpT5wPq4B6_kQ1jEFelxdTgcM1KdMSwrLMIVpXinGo40jnjHO1EZHy1JmW-MczRjQFqTJUzf5sMSp2PCFfPQ2FPz6b2_J7x_fX3aPbP_r59PuYc9GIfuZCeH9KNuhG5sO9Gi7XnWNdhLH3ttG-RaHFhpQynVcCSsqiF47xzslB9RKNltye8295PS6YJnNKS051kojNK-clGreVOKqGnMqJaM3l0rA5tVwMG90zZWuqXTNX7pmrabmaipVHA-Y36P_4_oDgcyAdg</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Kegley, Zachary</creator><creator>Makay, Michael</creator><creator>Rogers, Joshua</creator><creator>Phelps, Katrina</creator><creator>Malcom, Colleen</creator><creator>Hellmig, David</creator><creator>Kroninger, Anna</creator><creator>Bi, Xiangdong</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>L6V</scope><scope>M7S</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><orcidid>https://orcid.org/0000-0002-8425-8468</orcidid></search><sort><creationdate>20221001</creationdate><title>Polyamidoamine dendrimer-polyethylene glycol hydrogel for solubility enhancement and sustained release of diflunisal</title><author>Kegley, Zachary ; Makay, Michael ; Rogers, Joshua ; Phelps, Katrina ; Malcom, Colleen ; Hellmig, David ; Kroninger, Anna ; Bi, Xiangdong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c249t-22ffc45b8c3807ca896837d4ec9fa36f5eb503066d8162a200797dd1864be7643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aqueous solutions</topic><topic>Ceramics</topic><topic>Chemistry and Materials Science</topic><topic>Composites</topic><topic>Crosslinking</topic><topic>Drug delivery systems</topic><topic>Encapsulation</topic><topic>Glass</topic><topic>Hydrogels</topic><topic>Hydrophobicity</topic><topic>Inorganic Chemistry</topic><topic>Materials Science</topic><topic>Nanotechnology</topic><topic>Natural Materials</topic><topic>Optical and Electronic Materials</topic><topic>Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications</topic><topic>Polyethylene glycol</topic><topic>Solubility</topic><topic>Sustained release</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kegley, Zachary</creatorcontrib><creatorcontrib>Makay, Michael</creatorcontrib><creatorcontrib>Rogers, Joshua</creatorcontrib><creatorcontrib>Phelps, Katrina</creatorcontrib><creatorcontrib>Malcom, Colleen</creatorcontrib><creatorcontrib>Hellmig, David</creatorcontrib><creatorcontrib>Kroninger, Anna</creatorcontrib><creatorcontrib>Bi, Xiangdong</creatorcontrib><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>ProQuest Engineering Collection</collection><collection>Engineering Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><jtitle>Journal of sol-gel science and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kegley, Zachary</au><au>Makay, Michael</au><au>Rogers, Joshua</au><au>Phelps, Katrina</au><au>Malcom, Colleen</au><au>Hellmig, David</au><au>Kroninger, Anna</au><au>Bi, Xiangdong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polyamidoamine dendrimer-polyethylene glycol hydrogel for solubility enhancement and sustained release of diflunisal</atitle><jtitle>Journal of sol-gel science and technology</jtitle><stitle>J Sol-Gel Sci Technol</stitle><date>2022-10-01</date><risdate>2022</risdate><volume>104</volume><issue>1</issue><spage>160</spage><epage>168</epage><pages>160-168</pages><issn>0928-0707</issn><eissn>1573-4846</eissn><abstract>The purpose of this research is to develop a hydrogel delivery system for solubility enhancement and sustained release of hydrophobic drugs. The model drug, diflunisal, has documented poor solubility in water which limits its application and administration. In this research, polyamidoamine (PAMAM) dendrimer is employed to dramatically increase the water solubility of diflunisal. In the meantime, PAMAM dendrimer functionalized with crosslinkers is further in situ crosslinked with thiolated polyethylene glycol (PEG) to form a hydrogel, encapsulating a high payload of diflunisal for sustained release. The diflunisal encapsulated hydrogel is immersed in water or laid on top of mouse skin, and the amount of diflunisal released from the gel is quantitatively measured by UV-Vis spectroscopy. Results show that the solubility of diflunisal in water is improved by 129–193 folds in the presence of PAMAM dendrimer at the experimental conditions compared to the reported solubility, and the amount of diflunisal is released by up to 87% of its load and reaches its maximum amounts after 72 h. This research demonstrates that the PAMAM dendrimer-PEG hydrogel system may serve as a promising delivery system for hydrophobic drugs.
Vinyl sulfone functionalized PAMAM dendrimer increases the water solubilty of hydrophobic anti-inflammatory drug diflunisal, and crosslinks with thiolated mutibranched PEG to form a hydrogel. A large payload of diflunisal is released from hydrogel and penetrates into mouse skin in a controllable manner depending on the hydrogel crosslinking density which can be chemically modified.
Highlights
PAMAM dendrimer-mediated hydrogel platforms with tunable structures for sustained drug delivery.
129–193-fold solubility increase of hydrophobic drug diflunisal.
74–87% drug release in 72 h either in aqueous media or through mouse skin penetration.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10971-022-05904-y</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8425-8468</orcidid></addata></record> |
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| ispartof | Journal of sol-gel science and technology, 2022-10, Vol.104 (1), p.160-168 |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Aqueous solutions Ceramics Chemistry and Materials Science Composites Crosslinking Drug delivery systems Encapsulation Glass Hydrogels Hydrophobicity Inorganic Chemistry Materials Science Nanotechnology Natural Materials Optical and Electronic Materials Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications Polyethylene glycol Solubility Sustained release |
| title | Polyamidoamine dendrimer-polyethylene glycol hydrogel for solubility enhancement and sustained release of diflunisal |
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