Targetability of the neurovascular unit in inflammatory diseases of the central nervous system

Summary The blood–brain barrier (BBB) is a selectively permeable barrier separating the periphery from the central nervous system (CNS). The BBB restricts the flow of most material into and out of the CNS, including many drugs that could be used as potent therapies. BBB permeability is modulated by...

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Veröffentlicht in:	Immunological reviews 2022-10, Vol.311 (1), p.39-49
Hauptverfasser:	Smith, Brandon C., Tinkey, Rachel A., Shaw, Benjamin C., Williams, Jessica L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Astrocytes Astrocytes - metabolism Basal lamina Blood-brain barrier Blood-Brain Barrier - physiology Capillaries Central Nervous System endothelial cell Endothelial cells Endothelial Cells - physiology glia Humans Inflammatory diseases Membrane permeability Microglia Nervous system neuroinflammatory disease Neurons pericyte Pericytes Pericytes - metabolism Permeability tight junction Tight junctions
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