Targetability of the neurovascular unit in inflammatory diseases of the central nervous system
Summary The blood–brain barrier (BBB) is a selectively permeable barrier separating the periphery from the central nervous system (CNS). The BBB restricts the flow of most material into and out of the CNS, including many drugs that could be used as potent therapies. BBB permeability is modulated by...
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| Veröffentlicht in: | Immunological reviews 2022-10, Vol.311 (1), p.39-49 |
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| creator | Smith, Brandon C. Tinkey, Rachel A. Shaw, Benjamin C. Williams, Jessica L. |
| description | Summary
The blood–brain barrier (BBB) is a selectively permeable barrier separating the periphery from the central nervous system (CNS). The BBB restricts the flow of most material into and out of the CNS, including many drugs that could be used as potent therapies. BBB permeability is modulated by several cells that are collectively called the neurovascular unit (NVU). The NVU consists of specialized CNS endothelial cells (ECs), pericytes, astrocytes, microglia, and neurons. CNS ECs maintain a complex “seal” via tight junctions, forming the BBB; breakdown of these tight junctions leads to BBB disruption. Pericytes control the vascular flow within capillaries and help maintain the basal lamina. Astrocytes control much of the flow of material that has moved beyond the CNS EC layer and can form a secondary barrier under inflammatory conditions. Microglia survey the border of the NVU for noxious material. Neuronal activity also plays a role in the maintenance of the BBB. Since astrocytes, pericytes, microglia, and neurons are all able to modulate the permeability of the BBB, understating the complex contributions of each member of the NVU will potentially uncover novel and effective methods for delivery of neurotherapies to the CNS. |
| doi_str_mv | 10.1111/imr.13121 |
| format | Article |
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The blood–brain barrier (BBB) is a selectively permeable barrier separating the periphery from the central nervous system (CNS). The BBB restricts the flow of most material into and out of the CNS, including many drugs that could be used as potent therapies. BBB permeability is modulated by several cells that are collectively called the neurovascular unit (NVU). The NVU consists of specialized CNS endothelial cells (ECs), pericytes, astrocytes, microglia, and neurons. CNS ECs maintain a complex “seal” via tight junctions, forming the BBB; breakdown of these tight junctions leads to BBB disruption. Pericytes control the vascular flow within capillaries and help maintain the basal lamina. Astrocytes control much of the flow of material that has moved beyond the CNS EC layer and can form a secondary barrier under inflammatory conditions. Microglia survey the border of the NVU for noxious material. Neuronal activity also plays a role in the maintenance of the BBB. Since astrocytes, pericytes, microglia, and neurons are all able to modulate the permeability of the BBB, understating the complex contributions of each member of the NVU will potentially uncover novel and effective methods for delivery of neurotherapies to the CNS.</description><identifier>ISSN: 0105-2896</identifier><identifier>EISSN: 1600-065X</identifier><identifier>DOI: 10.1111/imr.13121</identifier><identifier>PMID: 35909222</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Astrocytes ; Astrocytes - metabolism ; Basal lamina ; Blood-brain barrier ; Blood-Brain Barrier - physiology ; Capillaries ; Central Nervous System ; endothelial cell ; Endothelial cells ; Endothelial Cells - physiology ; glia ; Humans ; Inflammatory diseases ; Membrane permeability ; Microglia ; Nervous system ; neuroinflammatory disease ; Neurons ; pericyte ; Pericytes ; Pericytes - metabolism ; Permeability ; tight junction ; Tight junctions</subject><ispartof>Immunological reviews, 2022-10, Vol.311 (1), p.39-49</ispartof><rights>2022 The Authors. published by John Wiley & Sons Ltd.</rights><rights>2022 The Authors. Immunological Reviews published by John Wiley & Sons Ltd.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3881-4ad3ee1e35e2d7eff133ffac62ae7d1035607493ec7c7bb3bdd63a3902f6c7773</citedby><cites>FETCH-LOGICAL-c3881-4ad3ee1e35e2d7eff133ffac62ae7d1035607493ec7c7bb3bdd63a3902f6c7773</cites><orcidid>0000-0002-9801-9580 ; 0000-0001-8862-3840</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fimr.13121$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fimr.13121$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>315,782,786,1419,27933,27934,45583,45584</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35909222$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, Brandon C.</creatorcontrib><creatorcontrib>Tinkey, Rachel A.</creatorcontrib><creatorcontrib>Shaw, Benjamin C.</creatorcontrib><creatorcontrib>Williams, Jessica L.</creatorcontrib><title>Targetability of the neurovascular unit in inflammatory diseases of the central nervous system</title><title>Immunological reviews</title><addtitle>Immunol Rev</addtitle><description>Summary
The blood–brain barrier (BBB) is a selectively permeable barrier separating the periphery from the central nervous system (CNS). The BBB restricts the flow of most material into and out of the CNS, including many drugs that could be used as potent therapies. BBB permeability is modulated by several cells that are collectively called the neurovascular unit (NVU). The NVU consists of specialized CNS endothelial cells (ECs), pericytes, astrocytes, microglia, and neurons. CNS ECs maintain a complex “seal” via tight junctions, forming the BBB; breakdown of these tight junctions leads to BBB disruption. Pericytes control the vascular flow within capillaries and help maintain the basal lamina. Astrocytes control much of the flow of material that has moved beyond the CNS EC layer and can form a secondary barrier under inflammatory conditions. Microglia survey the border of the NVU for noxious material. Neuronal activity also plays a role in the maintenance of the BBB. Since astrocytes, pericytes, microglia, and neurons are all able to modulate the permeability of the BBB, understating the complex contributions of each member of the NVU will potentially uncover novel and effective methods for delivery of neurotherapies to the CNS.</description><subject>Astrocytes</subject><subject>Astrocytes - metabolism</subject><subject>Basal lamina</subject><subject>Blood-brain barrier</subject><subject>Blood-Brain Barrier - physiology</subject><subject>Capillaries</subject><subject>Central Nervous System</subject><subject>endothelial cell</subject><subject>Endothelial cells</subject><subject>Endothelial Cells - physiology</subject><subject>glia</subject><subject>Humans</subject><subject>Inflammatory diseases</subject><subject>Membrane permeability</subject><subject>Microglia</subject><subject>Nervous system</subject><subject>neuroinflammatory disease</subject><subject>Neurons</subject><subject>pericyte</subject><subject>Pericytes</subject><subject>Pericytes - metabolism</subject><subject>Permeability</subject><subject>tight junction</subject><subject>Tight junctions</subject><issn>0105-2896</issn><issn>1600-065X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kE1LAzEQhoMotlYP_gFZ8ORh23x0k-5RxI9CRZAKngzZ7ERT9qMm2cr-e6NtvTkMM5dn3oEHoXOCxyTWxNZuTBih5AANCcc4xTx7PURDTHCW0lnOB-jE-xXGRDA6PUYDluU4p5QO0dtSuXcIqrCVDX3SmiR8QNJA59qN8rqrlEu6xobENrFNpepahdb1SWk9KA9-f6KhCU5V8dRt2s4nvvcB6lN0ZFTl4Wy3R-jl7nZ585Aunu7nN9eLVLPZjKRTVTIAAiwDWgowhjBmjNKcKhAlwSzjWExzBlpoURSsKEvOFMsxNVwLIdgIXW5z16797MAHuWo718SXkgqSMUF4nCN0taW0a713YOTa2Vq5XhIsf0zKaFL-mozsxS6xK2oo_8i9ughMtsCXraD_P0nOH5-3kd-nzX7X</recordid><startdate>202210</startdate><enddate>202210</enddate><creator>Smith, Brandon C.</creator><creator>Tinkey, Rachel A.</creator><creator>Shaw, Benjamin C.</creator><creator>Williams, Jessica L.</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>M7N</scope><orcidid>https://orcid.org/0000-0002-9801-9580</orcidid><orcidid>https://orcid.org/0000-0001-8862-3840</orcidid></search><sort><creationdate>202210</creationdate><title>Targetability of the neurovascular unit in inflammatory diseases of the central nervous system</title><author>Smith, Brandon C. ; Tinkey, Rachel A. ; Shaw, Benjamin C. ; Williams, Jessica L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3881-4ad3ee1e35e2d7eff133ffac62ae7d1035607493ec7c7bb3bdd63a3902f6c7773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Astrocytes</topic><topic>Astrocytes - metabolism</topic><topic>Basal lamina</topic><topic>Blood-brain barrier</topic><topic>Blood-Brain Barrier - physiology</topic><topic>Capillaries</topic><topic>Central Nervous System</topic><topic>endothelial cell</topic><topic>Endothelial cells</topic><topic>Endothelial Cells - physiology</topic><topic>glia</topic><topic>Humans</topic><topic>Inflammatory diseases</topic><topic>Membrane permeability</topic><topic>Microglia</topic><topic>Nervous system</topic><topic>neuroinflammatory disease</topic><topic>Neurons</topic><topic>pericyte</topic><topic>Pericytes</topic><topic>Pericytes - metabolism</topic><topic>Permeability</topic><topic>tight junction</topic><topic>Tight junctions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, Brandon C.</creatorcontrib><creatorcontrib>Tinkey, Rachel A.</creatorcontrib><creatorcontrib>Shaw, Benjamin C.</creatorcontrib><creatorcontrib>Williams, Jessica L.</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Immunological reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, Brandon C.</au><au>Tinkey, Rachel A.</au><au>Shaw, Benjamin C.</au><au>Williams, Jessica L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Targetability of the neurovascular unit in inflammatory diseases of the central nervous system</atitle><jtitle>Immunological reviews</jtitle><addtitle>Immunol Rev</addtitle><date>2022-10</date><risdate>2022</risdate><volume>311</volume><issue>1</issue><spage>39</spage><epage>49</epage><pages>39-49</pages><issn>0105-2896</issn><eissn>1600-065X</eissn><abstract>Summary
The blood–brain barrier (BBB) is a selectively permeable barrier separating the periphery from the central nervous system (CNS). The BBB restricts the flow of most material into and out of the CNS, including many drugs that could be used as potent therapies. BBB permeability is modulated by several cells that are collectively called the neurovascular unit (NVU). The NVU consists of specialized CNS endothelial cells (ECs), pericytes, astrocytes, microglia, and neurons. CNS ECs maintain a complex “seal” via tight junctions, forming the BBB; breakdown of these tight junctions leads to BBB disruption. Pericytes control the vascular flow within capillaries and help maintain the basal lamina. Astrocytes control much of the flow of material that has moved beyond the CNS EC layer and can form a secondary barrier under inflammatory conditions. Microglia survey the border of the NVU for noxious material. Neuronal activity also plays a role in the maintenance of the BBB. Since astrocytes, pericytes, microglia, and neurons are all able to modulate the permeability of the BBB, understating the complex contributions of each member of the NVU will potentially uncover novel and effective methods for delivery of neurotherapies to the CNS.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>35909222</pmid><doi>10.1111/imr.13121</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9801-9580</orcidid><orcidid>https://orcid.org/0000-0001-8862-3840</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Astrocytes Astrocytes - metabolism Basal lamina Blood-brain barrier Blood-Brain Barrier - physiology Capillaries Central Nervous System endothelial cell Endothelial cells Endothelial Cells - physiology glia Humans Inflammatory diseases Membrane permeability Microglia Nervous system neuroinflammatory disease Neurons pericyte Pericytes Pericytes - metabolism Permeability tight junction Tight junctions |
| title | Targetability of the neurovascular unit in inflammatory diseases of the central nervous system |
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