Innovative treatments for epilepsy: Venom peptides, cannabinoids, and neurostimulation
Antiepileptic drugs have been successfully treating epilepsy and providing individuals sustained seizure freedom. However, about 30% of the patients with epilepsy present drug resistance, which means they are not responsive to the pharmacological treatment. Considering this, it becomes extremely rel...
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| Veröffentlicht in: | Journal of neuroscience research 2022-11, Vol.100 (11), p.1969-1986 |
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| container_end_page | 1986 |
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| container_issue | 11 |
| container_start_page | 1969 |
| container_title | Journal of neuroscience research |
| container_volume | 100 |
| creator | Lima, Larissa Silva de Loyola, Vinícius Bicca, João Victor Montenegro Luzardo Faro, Lucas Vale, Camilla Lepesqueur Costa Lotufo Denucci, Bruna Mortari, Márcia Renata |
| description | Antiepileptic drugs have been successfully treating epilepsy and providing individuals sustained seizure freedom. However, about 30% of the patients with epilepsy present drug resistance, which means they are not responsive to the pharmacological treatment. Considering this, it becomes extremely relevant to pursue alternative therapeutic approaches, in order to provide appropriate treatment for those patients and also improve their quality of life. In the light of that, this review aims to discuss some innovative options for the treatment of epilepsy, which are currently under investigation, addressing strategies that go from therapeutic compounds to clinical procedures. For instance, peptides derived from animal venoms, such as wasps, spiders, and scorpions, demonstrate to be promising antiepileptic molecules, acting on a variety of targets. Other options are cannabinoids and compounds that modulate the endocannabinoid system, since it is now known that this network is involved in the pathophysiology of epilepsy. Furthermore, neurostimulation is another strategy, being an alternative clinical procedure for drug‐resistant patients who are not eligible for palliative surgeries.
This article reviews the most innovative treatments for epilepsy, given the great percentage of drug resistant patients. The topics addressed include neuromodulation, peptides derived from animal venoms, cannabinoids and nanoparticles. |
| doi_str_mv | 10.1002/jnr.25114 |
| format | Article |
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This article reviews the most innovative treatments for epilepsy, given the great percentage of drug resistant patients. The topics addressed include neuromodulation, peptides derived from animal venoms, cannabinoids and nanoparticles.</description><subject>Animals</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Antiepileptic agents</subject><subject>Cannabinoids</subject><subject>Cannabinoids - pharmacology</subject><subject>Cannabinoids - therapeutic use</subject><subject>Chemical compounds</subject><subject>Drug resistance</subject><subject>Drug therapy</subject><subject>Endocannabinoid system</subject><subject>Endocannabinoids</subject><subject>Epilepsy</subject><subject>Epilepsy - drug therapy</subject><subject>nanoparticles</subject><subject>neurostimulation</subject><subject>Patients</subject><subject>Peptides</subject><subject>Pharmacology</subject><subject>pharmacoresistance</subject><subject>Quality of Life</subject><subject>Seizures</subject><subject>Venom</subject><subject>Venoms - therapeutic use</subject><issn>0360-4012</issn><issn>1097-4547</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKw0AUQAdRbH0s_AEJuBJMO8_EcSfFR6UoiHY7TCY3kNLMxJmk0r93NNWdq8uFw7mXg9AZwROCMZ2urJ9QQQjfQ2OCZZ5ywfN9NMYswynHhI7QUQgrjLGUgh2iEROScUnpGC3n1rqN7uoNJJ0H3TVgu5BUzifQ1mtow_YmWYJ1TdJC29UlhKvEaGt1UVtXl3HTtkws9N6Frm76dXQ5e4IOKr0OcLqbx-j9_u5t9pguXh7ms9tFaphgPDUFz6Q2GeZaSJoVJs8ppYZpTUAWXHMBIr8uCFBCsgyM5LgSEqocCJhMM3aMLgZv691HD6FTK9d7G08qmhOeE8IkjdTlQJn4ZPBQqdbXjfZbRbD6LqhiQfVTMLLnO2NfNFD-kb_JIjAdgM-YZ_u_ST09vw7KLz86eyg</recordid><startdate>202211</startdate><enddate>202211</enddate><creator>Lima, Larissa Silva de</creator><creator>Loyola, Vinícius</creator><creator>Bicca, João Victor Montenegro Luzardo</creator><creator>Faro, Lucas</creator><creator>Vale, Camilla Lepesqueur Costa</creator><creator>Lotufo Denucci, Bruna</creator><creator>Mortari, Márcia Renata</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0002-7050-5560</orcidid><orcidid>https://orcid.org/0000-0002-6849-6001</orcidid></search><sort><creationdate>202211</creationdate><title>Innovative treatments for epilepsy: Venom peptides, cannabinoids, and neurostimulation</title><author>Lima, Larissa Silva de ; Loyola, Vinícius ; Bicca, João Victor Montenegro Luzardo ; Faro, Lucas ; Vale, Camilla Lepesqueur Costa ; Lotufo Denucci, Bruna ; Mortari, Márcia Renata</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3534-cb469ac604a5926bc77222c3aa1e9b4a45e578b1e21166ec940f59ef7e1ec6a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Antiepileptic agents</topic><topic>Cannabinoids</topic><topic>Cannabinoids - pharmacology</topic><topic>Cannabinoids - therapeutic use</topic><topic>Chemical compounds</topic><topic>Drug resistance</topic><topic>Drug therapy</topic><topic>Endocannabinoid system</topic><topic>Endocannabinoids</topic><topic>Epilepsy</topic><topic>Epilepsy - drug therapy</topic><topic>nanoparticles</topic><topic>neurostimulation</topic><topic>Patients</topic><topic>Peptides</topic><topic>Pharmacology</topic><topic>pharmacoresistance</topic><topic>Quality of Life</topic><topic>Seizures</topic><topic>Venom</topic><topic>Venoms - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lima, Larissa Silva de</creatorcontrib><creatorcontrib>Loyola, Vinícius</creatorcontrib><creatorcontrib>Bicca, João Victor Montenegro Luzardo</creatorcontrib><creatorcontrib>Faro, Lucas</creatorcontrib><creatorcontrib>Vale, Camilla Lepesqueur Costa</creatorcontrib><creatorcontrib>Lotufo Denucci, Bruna</creatorcontrib><creatorcontrib>Mortari, Márcia Renata</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lima, Larissa Silva de</au><au>Loyola, Vinícius</au><au>Bicca, João Victor Montenegro Luzardo</au><au>Faro, Lucas</au><au>Vale, Camilla Lepesqueur Costa</au><au>Lotufo Denucci, Bruna</au><au>Mortari, Márcia Renata</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Innovative treatments for epilepsy: Venom peptides, cannabinoids, and neurostimulation</atitle><jtitle>Journal of neuroscience research</jtitle><addtitle>J Neurosci Res</addtitle><date>2022-11</date><risdate>2022</risdate><volume>100</volume><issue>11</issue><spage>1969</spage><epage>1986</epage><pages>1969-1986</pages><issn>0360-4012</issn><eissn>1097-4547</eissn><abstract>Antiepileptic drugs have been successfully treating epilepsy and providing individuals sustained seizure freedom. However, about 30% of the patients with epilepsy present drug resistance, which means they are not responsive to the pharmacological treatment. Considering this, it becomes extremely relevant to pursue alternative therapeutic approaches, in order to provide appropriate treatment for those patients and also improve their quality of life. In the light of that, this review aims to discuss some innovative options for the treatment of epilepsy, which are currently under investigation, addressing strategies that go from therapeutic compounds to clinical procedures. For instance, peptides derived from animal venoms, such as wasps, spiders, and scorpions, demonstrate to be promising antiepileptic molecules, acting on a variety of targets. Other options are cannabinoids and compounds that modulate the endocannabinoid system, since it is now known that this network is involved in the pathophysiology of epilepsy. Furthermore, neurostimulation is another strategy, being an alternative clinical procedure for drug‐resistant patients who are not eligible for palliative surgeries.
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Animals Anticonvulsants - therapeutic use Antiepileptic agents Cannabinoids Cannabinoids - pharmacology Cannabinoids - therapeutic use Chemical compounds Drug resistance Drug therapy Endocannabinoid system Endocannabinoids Epilepsy Epilepsy - drug therapy nanoparticles neurostimulation Patients Peptides Pharmacology pharmacoresistance Quality of Life Seizures Venom Venoms - therapeutic use |
| title | Innovative treatments for epilepsy: Venom peptides, cannabinoids, and neurostimulation |
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