Cyanine Dyes as Fluorogens for FAST and NanoFAST Proteins

Cyanine Dyes as Fluorogens for FAST and NanoFAST Proteins

— Seven new cyanine dyes were synthesized. These compounds, together with eleven described derivatives of the same class, have been probed as fluorogens for the FAST and nanoFAST proteins. The study of the increase in fluorescence intensity upon interaction with these proteins allowed us to identify...

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Veröffentlicht in:Russian journal of bioorganic chemistry 2022-08, Vol.48 (4), p.846-849
Hauptverfasser: Khrulev, A. A., Baleeva, N. S., Kamzeeva, P. N., Baranov, M. S., Aralov, A. V.
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Cyanine dyes
Letters to the Editor
Life Sciences
Organic Chemistry
Proteins
Structural members
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Zusammenfassung:— Seven new cyanine dyes were synthesized. These compounds, together with eleven described derivatives of the same class, have been probed as fluorogens for the FAST and nanoFAST proteins. The study of the increase in fluorescence intensity upon interaction with these proteins allowed us to identify structural elements suitable for the design of protein-labeling systems based on cyanine dye–fluorogen-activating protein pairs.
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162022040112