Decreased vitamin D levels in children and adolescents with Celiac disease: A nationwide cross-sectional study
Aims: Vitamin D deficiency results from malabsorption in Celiac disease (CD), and it may also be involved in the pathogenesis of CD. There is no clarity regarding vitamin D deficiency in CD. We investigated the frequency of vitamin D deficiency in children with CD compared with controls. Methods: Th...
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| Veröffentlicht in: | Gulhane Medical Journal 2022-09, Vol.64 (3), p.268-273 |
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| creator | Akelma, Zulfikar Keskin, Meliksah Erdeve, Senay Savas Bursa, Nurbanu Celik, Osman imrat, Ersan Ulgu, Mustafa Mahir Caglayan, Murat Ata, Naim Birinci, Suayip |
| description | Aims: Vitamin D deficiency results from malabsorption in Celiac disease (CD), and it may also be involved in the pathogenesis of CD. There is no clarity regarding vitamin D deficiency in CD. We investigated the frequency of vitamin D deficiency in children with CD compared with controls. Methods: The database of the Turkish Ministry of Health was used for the cross-sectional descriptive study. Children with CD whose serum tissue transglutaminase (tTG) and serum 25-hydroxyvitamin D [25(OH)D] levels were available in the registry were included. The CD group was further subdivided into tTG (IgG and/or IgA) antibody-negative and positive subgroups. Individuals with CD were classified as compatible and non-compatible with a gluten-free diet (GFD) (GFD-compatible and GFD-non-compatible groups), respectively. Children who had no known malabsorption syndrome formed the control group. Results: The median serum 25(OH)D level was 18.5 ng/mL in children with CD (n=6717) and 30.7 ng/mL in the control group (n=6717) (p |
| doi_str_mv | 10.4274/gulhane.galenos.2022.38039 |
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There is no clarity regarding vitamin D deficiency in CD. We investigated the frequency of vitamin D deficiency in children with CD compared with controls. Methods: The database of the Turkish Ministry of Health was used for the cross-sectional descriptive study. Children with CD whose serum tissue transglutaminase (tTG) and serum 25-hydroxyvitamin D [25(OH)D] levels were available in the registry were included. The CD group was further subdivided into tTG (IgG and/or IgA) antibody-negative and positive subgroups. Individuals with CD were classified as compatible and non-compatible with a gluten-free diet (GFD) (GFD-compatible and GFD-non-compatible groups), respectively. Children who had no known malabsorption syndrome formed the control group. Results: The median serum 25(OH)D level was 18.5 ng/mL in children with CD (n=6717) and 30.7 ng/mL in the control group (n=6717) (p<0.001). The vitamin D levels of the GFDcompatible (n=1102) and GFD-non-compatible groups (n=5615) were 19.36 ng/mL and 18.30 ng/mL, respectively (p<0.001). The rate of vitamin D deficiency was 56% in the CD group and 12% in the control group (p<0.001). Conclusions: This study found significantly lower serum vitamin D levels in children and adolescents with CD. The results suggest children with CD should be evaluated for vitamin D levels and followed periodically. Keywords: 25-hydroxyvitamin D, vitamin D deficiency, transglutaminase antibody, gluten-free diet</description><identifier>ISSN: 1302-0471</identifier><identifier>EISSN: 2146-8052</identifier><identifier>DOI: 10.4274/gulhane.galenos.2022.38039</identifier><language>eng</language><publisher>Ankara: Galenos Yayinevi Tic. Ltd</publisher><subject>25-hydroxyvitamin d ; Age ; Alfacalcidol ; Antibodies ; Calcifediol ; Celiac disease ; Children ; Comparative analysis ; Cross-sectional studies ; Gluten ; gluten-free diet ; Immunoglobulin G ; Metabolism ; Pathogenesis ; Teenagers ; transglutaminase antibody ; Vitamin D ; vitamin d deficiency ; Vitamin deficiency</subject><ispartof>Gulhane Medical Journal, 2022-09, Vol.64 (3), p.268-273</ispartof><rights>COPYRIGHT 2022 Galenos Yayinevi Tic. Ltd.</rights><rights>2022. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3919-fca039cde5e6228b183763d69c8ae82a513bf43c344c3f9870675942d1e14f193</citedby><cites>FETCH-LOGICAL-c3919-fca039cde5e6228b183763d69c8ae82a513bf43c344c3f9870675942d1e14f193</cites><orcidid>0000-0003-0140-5053 ; 0000-0002-2713-3618 ; 0000-0001-8801-8771 ; 0000-0003-3486-6067 ; 0000-0002-4164-5089 ; 0000-0003-2131-2866 ; 0000-0001-8104-6198 ; 0000-0003-3747-5870 ; 0000-0003-0825-1851 ; 0000-0001-6947-2821</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,2100,27915,27916</link.rule.ids></links><search><creatorcontrib>Akelma, Zulfikar</creatorcontrib><creatorcontrib>Keskin, Meliksah</creatorcontrib><creatorcontrib>Erdeve, Senay Savas</creatorcontrib><creatorcontrib>Bursa, Nurbanu</creatorcontrib><creatorcontrib>Celik, Osman</creatorcontrib><creatorcontrib>imrat, Ersan</creatorcontrib><creatorcontrib>Ulgu, Mustafa Mahir</creatorcontrib><creatorcontrib>Caglayan, Murat</creatorcontrib><creatorcontrib>Ata, Naim</creatorcontrib><creatorcontrib>Birinci, Suayip</creatorcontrib><title>Decreased vitamin D levels in children and adolescents with Celiac disease: A nationwide cross-sectional study</title><title>Gulhane Medical Journal</title><description>Aims: Vitamin D deficiency results from malabsorption in Celiac disease (CD), and it may also be involved in the pathogenesis of CD. There is no clarity regarding vitamin D deficiency in CD. We investigated the frequency of vitamin D deficiency in children with CD compared with controls. Methods: The database of the Turkish Ministry of Health was used for the cross-sectional descriptive study. Children with CD whose serum tissue transglutaminase (tTG) and serum 25-hydroxyvitamin D [25(OH)D] levels were available in the registry were included. The CD group was further subdivided into tTG (IgG and/or IgA) antibody-negative and positive subgroups. Individuals with CD were classified as compatible and non-compatible with a gluten-free diet (GFD) (GFD-compatible and GFD-non-compatible groups), respectively. Children who had no known malabsorption syndrome formed the control group. Results: The median serum 25(OH)D level was 18.5 ng/mL in children with CD (n=6717) and 30.7 ng/mL in the control group (n=6717) (p<0.001). The vitamin D levels of the GFDcompatible (n=1102) and GFD-non-compatible groups (n=5615) were 19.36 ng/mL and 18.30 ng/mL, respectively (p<0.001). The rate of vitamin D deficiency was 56% in the CD group and 12% in the control group (p<0.001). Conclusions: This study found significantly lower serum vitamin D levels in children and adolescents with CD. The results suggest children with CD should be evaluated for vitamin D levels and followed periodically. Keywords: 25-hydroxyvitamin D, vitamin D deficiency, transglutaminase antibody, gluten-free diet</description><subject>25-hydroxyvitamin d</subject><subject>Age</subject><subject>Alfacalcidol</subject><subject>Antibodies</subject><subject>Calcifediol</subject><subject>Celiac disease</subject><subject>Children</subject><subject>Comparative analysis</subject><subject>Cross-sectional studies</subject><subject>Gluten</subject><subject>gluten-free diet</subject><subject>Immunoglobulin G</subject><subject>Metabolism</subject><subject>Pathogenesis</subject><subject>Teenagers</subject><subject>transglutaminase antibody</subject><subject>Vitamin D</subject><subject>vitamin d deficiency</subject><subject>Vitamin deficiency</subject><issn>1302-0471</issn><issn>2146-8052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNptUl1rGzEQPEoLcdP8B9E-31Vfd6fLm3GaNBDoS_ss1tLKlpGlVDon5N_nzjYJhbIPWoadYUc7VfWV0UbyXn7fHMIWIjYbCBhTaTjlvBGKiuFDteBMdrWiLf9YLZigvKayZxfV51J2lHZdy9SiijdoMkJBS578CHsfyQ0J-IShkKk3Wx9sxkggWgI2BSwG41jIsx-3ZIXBgyHWl1nhmixJhNGn-OwtEpNTKXVBMyMQSBkP9uVL9clBKHh1fi-rP7c_fq9-1g-_7u5Xy4faiIENtTMwWTAWW-w4V2umRN8J2w1GASoOLRNrJ4URUhrhBtXTrm8HyS1DJh0bxGV1f9K1CXb6Mfs95BedwOsjkPJGQx69CagBhbXt2iFFKq1jilNwnXLIrVwbZyatbyetx5z-HrCMepcOebJUNO8ZV6pvqXyfmk-hfXRpzGD2vhi97Oez8IHOezX_mZrK4t6bFNH5Cf-HcH0iHL8zo3szw6ieI6DPEdDnCOiZqo8REK8REKk-</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Akelma, Zulfikar</creator><creator>Keskin, Meliksah</creator><creator>Erdeve, Senay Savas</creator><creator>Bursa, Nurbanu</creator><creator>Celik, Osman</creator><creator>imrat, Ersan</creator><creator>Ulgu, Mustafa Mahir</creator><creator>Caglayan, Murat</creator><creator>Ata, Naim</creator><creator>Birinci, Suayip</creator><general>Galenos Yayinevi Tic. 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There is no clarity regarding vitamin D deficiency in CD. We investigated the frequency of vitamin D deficiency in children with CD compared with controls. Methods: The database of the Turkish Ministry of Health was used for the cross-sectional descriptive study. Children with CD whose serum tissue transglutaminase (tTG) and serum 25-hydroxyvitamin D [25(OH)D] levels were available in the registry were included. The CD group was further subdivided into tTG (IgG and/or IgA) antibody-negative and positive subgroups. Individuals with CD were classified as compatible and non-compatible with a gluten-free diet (GFD) (GFD-compatible and GFD-non-compatible groups), respectively. Children who had no known malabsorption syndrome formed the control group. Results: The median serum 25(OH)D level was 18.5 ng/mL in children with CD (n=6717) and 30.7 ng/mL in the control group (n=6717) (p<0.001). The vitamin D levels of the GFDcompatible (n=1102) and GFD-non-compatible groups (n=5615) were 19.36 ng/mL and 18.30 ng/mL, respectively (p<0.001). The rate of vitamin D deficiency was 56% in the CD group and 12% in the control group (p<0.001). Conclusions: This study found significantly lower serum vitamin D levels in children and adolescents with CD. The results suggest children with CD should be evaluated for vitamin D levels and followed periodically. Keywords: 25-hydroxyvitamin D, vitamin D deficiency, transglutaminase antibody, gluten-free diet</abstract><cop>Ankara</cop><pub>Galenos Yayinevi Tic. 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| subjects | 25-hydroxyvitamin d Age Alfacalcidol Antibodies Calcifediol Celiac disease Children Comparative analysis Cross-sectional studies Gluten gluten-free diet Immunoglobulin G Metabolism Pathogenesis Teenagers transglutaminase antibody Vitamin D vitamin d deficiency Vitamin deficiency |
| title | Decreased vitamin D levels in children and adolescents with Celiac disease: A nationwide cross-sectional study |
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