P38 Immune checkpoint inhibitor-induced colitis is mediated by CXCR6+ polyfunctional lymphocytes and dependent on IL23/IFNg axis

Background and AimsImmune checkpoint inhibitors (CPI) have revolutionised cancer treatment, with previously untreatable disease now amenable to potential cure. Combination regimens of anti-CTLA4 and anti-PD-1 show enhanced efficacy but are prone to off target immune-mediated tissue injury, particula...

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Veröffentlicht in:	Gut 2022-06, Vol.71 (Suppl 1), p.A56-A56
Hauptverfasser:	Lo, Jonathan, Cozzetto, Domenico, Liu, Zhigang, Ibraheim, Hajir, Sieh, Jillian, Olbei, Marton, Alexander, James, Blanco, Jesus Miguens, Madgwick, Matthew, Kudo, Hiromi, Seoane, Rocio Castro, Goldin, Robert, Marchesi, Julian, Korcsmaros, Tamas, Lord, Graham, Powell, Nick
Format:	Artikel
Sprache:	eng
Schlagworte:	CCL3 protein CCL4 protein CD4 antigen CD8 antigen Chemokine receptors Colitis Costimulator CTLA-4 protein Cytotoxicity Flow cytometry Homeostasis Immune checkpoint Immune checkpoint inhibitors Immune response Immunotherapy Inflammation Inflammatory bowel disease Interleukin 22 Interleukin 23 Intestinal microflora Intestine Lymphocytes Microbiota Mucosa PD-1 protein Poster presentations Therapeutic targets γ-Interferon
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