A study of chronopharmacological relevance of antihypertensive drugs prescription

[...]there will be variation in biological responses to medications which are related to time of administration of the drugs. [...]depending on the time of administration, there will be potential differences in responses of antibiotics to bacteria or of cancer cells to chemotherapy or radiotherapy, which defines the importance of chronopharmacologyW The new therapeutic drug targets can be identified by proper understanding of the molecular control of circadian rhythms and subsequent signaling pathways, which, in turn, provide better information regarding how more efficaciously and safely drugs can be administered. [9] Recent clinical studies show that signs and symptoms of many chronic medical condition fare up at specific time during 24 h which shows the magnitude of the predictable-in-time (rhythmic) differences. [...]circadian time has to be considered as an important variable influencing a drug's pharmacokinetics and its effects or side effects. Wide variety of antihypertensive drugs such as beta-blockers (propranolol, metoprolol, and atenolol), calcium channel blockers (amlodipine and nifedipine), ACE inhibitors (enalapril and lisinopril), ARBs (telmisartan), and diuretics (furosemide and hydrochlorothiazide) was used.