Cytochrome P450Blt Enables Versatile Peptide Cyclisation to Generate Histidine‐ and Tyrosine‐Containing Crosslinked Tripeptide Building Blocks

We report our investigation of the utility of peptide crosslinking cytochrome P450 enzymes from biarylitide biosynthesis to generate a range of cyclic tripeptides from simple synthons. The crosslinked tripeptides produced by this P450 include both tyrosine‐histidine (A−N−B) and tyrosine‐tryptophan (...

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Veröffentlicht in:	Angewandte Chemie 2022-09, Vol.134 (37), p.n/a
Hauptverfasser:	Zhao, Yongwei, Marschall, Edward, Treisman, Maxine, McKay, Alasdair, Padva, Leo, Crüsemann, Max, Nelson, David R., Steer, David L., Schittenhelm, Ralf B., Tailhades, Julien, Cryle, Max J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids Biocatalysis Biosynthesis Chemistry Crosslinking Cytochrome Cytochrome P450 Cytochromes P450 Enzymes Histidine Metalloenzymes Natural products Peptide Crosslinking Peptide Cyclisation Peptides Phenolic compounds Phenols Protein sorting signals Proteolysis Tryptophan Tyrosine
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