Novel tryptanthrin hybrids bearing aminothiazoles as potential EGFR inhibitors: Design, synthesis, biological screening, molecular docking studies, and ADME/T predictions

A variety of novel tryptanthrin aminothiazole analogues 3a‐h and 5a‐h possessing a biologically active thiazole moiety were synthesized by the reaction of tryptanthrin thiosemicarbazones with different α‐bromo‐4‐substituted‐acetophenones compounds. The structures of all the synthesized compounds wer...

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Veröffentlicht in:	Journal of heterocyclic chemistry 2022-09, Vol.59 (9), p.1533-1550
Hauptverfasser:	Palabindela, Rambabu, Guda, Ramu, Ramesh, Gondru, Myadaraveni, Prabhakar, Banothu, Devendar, Ravi, Gangalla, Korra, Rajashekar, Mekala, Himabindu, Kasula, Mamatha
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Cancer Chemical synthesis Inhibitors Molecular docking NMR Nuclear magnetic resonance
Online-Zugang:	Volltext
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