Relationship between Acral Lentiginous Melanoma and Exposure to UV Radiation

For clinically suspected melanomas, a narrow-margin excisional biopsy is recommended; however, it is recognized in the recommendations that this may not be practical in an acral site. [...]a partial sample of the lesion is considered an acceptable alternative, although the main risk with the partial sample is that it may result in an inaccurate histological diagnosis. [...]UV rays also benefit human health by mediating the natural synthesis of vitamin D and endorphins in the skin, thus UV rays have complex and mixed effects on human health [9, 12]. Ultraviolet rays are epidemiologically and molecularly related to the three most common types of skin cancer, basal cell carcinoma, squamous cell carcinoma, and malignant melanoma. [...]it is advisable to carry out this study, in order to clarify whether there is an association between exposure to ultraviolet rays and the development of acral lentiginous melanoma, since it is considered one of the poorly studied subtypes of melanoma. [...]in figure 2 we can show the most frequent forms and locations of acral lentiginous melanoma (Figure 2).