A pH‐Driven Small‐Molecule Nanotransformer Hijacks Lysosomes and Overcomes Autophagy‐Induced Resistance in Cancer

Smart conversion of supramolecular structures in vivo is an attractive strategy in cancer nanomedicine, which is usually achieved via specific peptide sequences. Here we developed a lysosomal targeting small‐molecule conjugate, PBC, which self‐assembles into nanoparticles at physiological pH and sma...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie 2022-08, Vol.134 (35), p.n/a
Hauptverfasser:	Ma, Zhao, Lin, Kai, Tang, Menghuan, Ramachandran, Mythili, Qiu, Reng, Li, Jin, Solano, Lucas N., Huang, Yanyu, De Souza, Cristabelle, Abou‐Adas, Sara, Xiang, Bai, Zhang, Lanwei, Li, Minyong, Li, Yuanpei
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antitumor activity Autophagy Biomedical materials Chemistry Lysosomes Nanofibrils Nanoparticles Nanotechnology pH effects Photodynamic Therapy Phototherapy Phototoxicity Transformable Nanoparticles Tumor cells Xenografts Xenotransplantation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!