First enantioselective synthesis of tetrahydrochromeno[2,3-b]carbazolylacetaldehyde via trienamine catalysis and its biological activity

The first enantioselective synthesis of a tetrahydrochromeno[2,3- b ]carbazole derivative via trienamine catalysis is presented. This molecule reduced the anxiety-like behavior in mice. On the contrary, its enantiomer showed low activity, demonstrating the importance of the stereochemisty in the cor...

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Veröffentlicht in:	Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2022-07, Vol.58 (6-7), p.358-362
Hauptverfasser:	Castillo-Espinoza, Carlos E., Pawar, Tushar Janardan, Alonso-Castro, Angel Josabad, Olivares-Romero, José Luis, Vázquez, Miguel A., Cruz, David Cruz, Gómez, Clarisa Villegas
Format:	Artikel
Sprache:	eng
Schlagworte:	Antidepressants Biological activity Carbazoles Catalysis Chemistry Chemistry and Materials Science Enantiomers Organic Chemistry Pharmacy Stereoisomers
Online-Zugang:	Volltext
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