Synthesis and Biological Activity of New Aminophosphabetaines

Aminophosphabetaines, i.e., isobutyl {[alkyl(dimethyl)ammonio]methyl}phosphonates with higher alkyl substituents at the nitrogen atom, were obtained by a three-stage synthesis. Structure of the compounds was established by IR, NMR spectroscopy and mass spectrometry methods. All compounds obtained de...

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Veröffentlicht in:	Russian journal of general chemistry 2022-07, Vol.92 (7), p.1208-1213
Hauptverfasser:	Gaineev, A. M., Galkina, I. V., Davletshin, R. R., Davletshina, N. V., Kuznetsov, N. O., Grishaev, D. Yu, Shulayeva, M. P., Pozdeev, O. K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Antiinfectives and antibacterials Biological activity Chemistry Chemistry and Materials Science Chemistry/Food Science Drug resistance in microorganisms E coli Escherichia coli Infrared spectroscopy Mass spectrometry NMR spectroscopy Nuclear magnetic resonance spectroscopy Phosphonates Synthesis
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Beschreibung
Zusammenfassung:	Aminophosphabetaines, i.e., isobutyl {[alkyl(dimethyl)ammonio]methyl}phosphonates with higher alkyl substituents at the nitrogen atom, were obtained by a three-stage synthesis. Structure of the compounds was established by IR, NMR spectroscopy and mass spectrometry methods. All compounds obtained demonstrate antimicrobial activity against Bacillus cereus , Staphylococcus aureus and Escherichia coli bacterial strains, as well as Candida albicans fungi.
ISSN:	1070-3632 1608-3350
DOI:	10.1134/S1070363222070052