Tcf-1 promotes genomic instability and T cell transformation in response to aberrant β-catenin activation

Understanding the mechanisms promoting chromosomal translocations of the rearranging receptor loci in leukemia and lymphoma remains incomplete. Here we show that leukemias induced by aberrant activation of β-catenin in thymocytes, which bear recurrent Tcra/Myc-Pvt1 translocations, depend on Tcf-1. T...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-08, Vol.119 (32)
Hauptverfasser:	Arnovitz, Stephen, Mathur, Priya, Tracy, Melissa, Mohsin, Azam, Mondal, Soumi, Quandt, Jasmin, Hernandez, Kyle M, Khazaie, Khashayarsha, Dose, Marei, Emmanuel, Akinola Olumide, Gounari, Fotini
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Acute lymphoblastic leukemia Chromatin Chromosome translocations Deoxyribonucleic acid DNA DNA biosynthesis DNA damage DNA repair Genetic transformation Genomic instability Homologous recombination Homology Leukemia Lymphocytes Lymphocytes T Lymphoma Myc protein Poly(ADP-ribose) polymerase Replication Retention Signaling T cell receptors Thymocytes Translocation Wnt protein β-Catenin
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