Deep‐Penetrating Triple‐Responsive Prodrug Nanosensitizer Actuates Efficient Chemoradiotherapy in Pancreatic Ductal Adenocarcinoma Models

Chemoradiotherapy (CRT) is the most accepted treatment for locally advanced pancreatic ductal adenocarcinoma (PDAC) and can significantly improve the R0 resection rate. However, there are few long‐term survivors after CRT. Although some polymer nanoparticles have shown potential in alleviating the d...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2022-08, Vol.18 (31), p.e2202834-n/a
Hauptverfasser:	Tang, Xiaohu, Du, Xiaomeng, Yu, Yanting, Qin, Meng, Qian, Lili, Zhang, Meng, Yang, Yan, Yu, Qingsong, Gan, Zhihua
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Pancreatic Ductal - drug therapy Chemoradiotherapy Chemotherapy concurrent chemoradiotherapy Drug delivery systems Glutathione Humans Hypoxia Hypoxia - drug therapy Nanoparticles Nanotechnology pancreatic ductal adenocarcinoma Pancreatic Neoplasms Pancreatic Neoplasms - drug therapy prodrug nanomedicine Prodrugs - therapeutic use Radiation therapy Toxicity tumor penetration Tumors γ‐glutamyl transpeptidase responsive
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