CMYA5 is a novel interaction partner of FHL2 in cardiac myocytes

Four‐and‐a‐half LIM domains protein 2 (FHL2) is an anti‐hypertrophic adaptor protein that regulates cardiac myocyte signalling and function. Herein, we identified cardiomyopathy‐associated 5 (CMYA5) as a novel FHL2 interaction partner in cardiac myocytes. In vitro pull‐down assays demonstrated inter...

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Veröffentlicht in:	The FEBS journal 2022-08, Vol.289 (15), p.4622-4645
Hauptverfasser:	Stathopoulou, Konstantina, Schnittger, Josef, Raabe, Janice, Fleischer, Frederic, Mangels, Nils, Piasecki, Angelika, Findlay, Jane, Hartmann, Kristin, Krasemann, Susanne, Schlossarek, Saskia, Uebeler, June, Wixler, Viktor, Blake, Derek J., Baillie, George S., Carrier, Lucie, Ehler, Elisabeth, Cuello, Friederike
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapters Adaptor proteins Animals Cardiac muscle cardiac myocyte Cardiomyocytes Cardiomyopathy Cardiomyopathy, Hypertrophic - metabolism cardiomyopathy‐associated 5 Confocal microscopy FHL2 protein four‐and‐a‐half LIM domains protein 2 Heart hypertrophy Immunofluorescence Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism LIM-Homeodomain Proteins - genetics LIM-Homeodomain Proteins - metabolism Mice Mice, Knockout Muscle Proteins - genetics Muscle Proteins - metabolism Myocardium - metabolism Myocytes Myocytes, Cardiac - metabolism Neonates Peptides Phenylephrine Proteins Rats scaffold protein Signal Transduction transcription Transcription Factors - genetics Transcription Factors - metabolism Ventricle
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