Fluorescent determination of cysteine and homocysteine via adjustable synthesis of flower-shaped covalent organic frameworks
Detection of cysteine (Cys) and homocysteine (Hcy) is very important for the early diagnosis and prevention of related diseases. Herein, we propose a facile, green, room-temperature controllable approach for the synthesis of fluorescent covalent organic frameworks (COFs) with high specific surface a...
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| Veröffentlicht in: | Sensors and actuators. B, Chemical Chemical, 2022-05, Vol.359, p.131555, Article 131555 |
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| creator | Wang, Yuting Chen, Jia Wang, Ganping Yu, Yongliang Wang, Jianhua Qiu, Hongdeng |
| description | Detection of cysteine (Cys) and homocysteine (Hcy) is very important for the early diagnosis and prevention of related diseases. Herein, we propose a facile, green, room-temperature controllable approach for the synthesis of fluorescent covalent organic frameworks (COFs) with high specific surface areas, high crystallinity, good morphology, excellent chemical and thermal stability by using 2,5-dimethoxyterephthaldehyde and 1,3,5-tris(4-aminophenyl)benzene as precursors. Interestingly, we found that the size and morphology of COFs could be controlled by the amount of acetic acid. With increasing numbers of acetic acid (HAc) molecules, the morphology of COFs gradually changed from spherical to flower-shaped, and the particle size gradually decreased from micrometer to nanometer. Furthermore, we were surprised to find that the reaction time influenced the uniform dispersion and crystallinity of flower-shaped COFs. With increasing the reaction time, the boundary around COFs became blurred, hierarchical flower-shaped COFs gradually appeared, and the flower-shaped gradually became clear and uniform. On this basis, the flower-shaped COFs were further used for highly sensitive determination of Cys and Hcy, with detection limits as low as 11.4 nM and 6.7 nM, respectively. The possible quenching mechanism was deduced by the Dmol3 package provided by Materials Studio and DFT calculations of Gaussian 09 software. This strategy could provide us a new insight into the controllable preparation of flower-shaped fluorescent COFs and broaden the application range of COFs for biomarker detection.
•Fluorescent COFs was prepared by a facile, green, room-temperature controllable approach.•The size and morphology of COFs could be controlled by the amount of acetic acid.•Uniform dispersion and crystallinity of flower-shaped COFs can be influenced by reaction time.•Highly sensitive determination of cysteine and homocysteine was obtained. |
| doi_str_mv | 10.1016/j.snb.2022.131555 |
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•Fluorescent COFs was prepared by a facile, green, room-temperature controllable approach.•The size and morphology of COFs could be controlled by the amount of acetic acid.•Uniform dispersion and crystallinity of flower-shaped COFs can be influenced by reaction time.•Highly sensitive determination of cysteine and homocysteine was obtained.</description><identifier>ISSN: 0925-4005</identifier><identifier>EISSN: 1873-3077</identifier><identifier>DOI: 10.1016/j.snb.2022.131555</identifier><language>eng</language><publisher>Lausanne: Elsevier B.V</publisher><subject>Acetic acid ; Benzene ; Bio-thiol detection ; Biomarkers ; Cell lysate ; Controllable preparation ; Covalent organic frameworks ; Crystal structure ; Crystallinity ; Cysteine ; Flowers ; Fluorescence ; Fluorescent materials ; Homocysteine ; Morphology ; Reaction time ; Room temperature ; Synthesis ; Thermal stability</subject><ispartof>Sensors and actuators. B, Chemical, 2022-05, Vol.359, p.131555, Article 131555</ispartof><rights>2022 Elsevier B.V.</rights><rights>Copyright Elsevier Science Ltd. May 15, 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c325t-def7b8b17a43675dcc711ba687a3fb28062f741e202d18340f1febf9a941a10f3</citedby><cites>FETCH-LOGICAL-c325t-def7b8b17a43675dcc711ba687a3fb28062f741e202d18340f1febf9a941a10f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.snb.2022.131555$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids></links><search><creatorcontrib>Wang, Yuting</creatorcontrib><creatorcontrib>Chen, Jia</creatorcontrib><creatorcontrib>Wang, Ganping</creatorcontrib><creatorcontrib>Yu, Yongliang</creatorcontrib><creatorcontrib>Wang, Jianhua</creatorcontrib><creatorcontrib>Qiu, Hongdeng</creatorcontrib><title>Fluorescent determination of cysteine and homocysteine via adjustable synthesis of flower-shaped covalent organic frameworks</title><title>Sensors and actuators. B, Chemical</title><description>Detection of cysteine (Cys) and homocysteine (Hcy) is very important for the early diagnosis and prevention of related diseases. Herein, we propose a facile, green, room-temperature controllable approach for the synthesis of fluorescent covalent organic frameworks (COFs) with high specific surface areas, high crystallinity, good morphology, excellent chemical and thermal stability by using 2,5-dimethoxyterephthaldehyde and 1,3,5-tris(4-aminophenyl)benzene as precursors. Interestingly, we found that the size and morphology of COFs could be controlled by the amount of acetic acid. With increasing numbers of acetic acid (HAc) molecules, the morphology of COFs gradually changed from spherical to flower-shaped, and the particle size gradually decreased from micrometer to nanometer. Furthermore, we were surprised to find that the reaction time influenced the uniform dispersion and crystallinity of flower-shaped COFs. With increasing the reaction time, the boundary around COFs became blurred, hierarchical flower-shaped COFs gradually appeared, and the flower-shaped gradually became clear and uniform. On this basis, the flower-shaped COFs were further used for highly sensitive determination of Cys and Hcy, with detection limits as low as 11.4 nM and 6.7 nM, respectively. The possible quenching mechanism was deduced by the Dmol3 package provided by Materials Studio and DFT calculations of Gaussian 09 software. This strategy could provide us a new insight into the controllable preparation of flower-shaped fluorescent COFs and broaden the application range of COFs for biomarker detection.
•Fluorescent COFs was prepared by a facile, green, room-temperature controllable approach.•The size and morphology of COFs could be controlled by the amount of acetic acid.•Uniform dispersion and crystallinity of flower-shaped COFs can be influenced by reaction time.•Highly sensitive determination of cysteine and homocysteine was obtained.</description><subject>Acetic acid</subject><subject>Benzene</subject><subject>Bio-thiol detection</subject><subject>Biomarkers</subject><subject>Cell lysate</subject><subject>Controllable preparation</subject><subject>Covalent organic frameworks</subject><subject>Crystal structure</subject><subject>Crystallinity</subject><subject>Cysteine</subject><subject>Flowers</subject><subject>Fluorescence</subject><subject>Fluorescent materials</subject><subject>Homocysteine</subject><subject>Morphology</subject><subject>Reaction time</subject><subject>Room temperature</subject><subject>Synthesis</subject><subject>Thermal stability</subject><issn>0925-4005</issn><issn>1873-3077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLxDAUhYMoOI7-AHcB161JX2lxJYMvGHCj65AmN05qJxmTdIYBf7wtFZeuLlzOOffcD6FrSlJKaHXbpcG2aUayLKU5LcvyBC1ozfIkJ4ydogVpsjIpCCnP0UUIHSGkyCuyQN-P_eA8BAk2YgUR_NZYEY2z2GksjyGCsYCFVXjjtu5vsTcCC9UNIYq2BxyONm4gmDC5dO8O4JOwETtQWLq96Kd05z-ENRJrL7ZwcP4zXKIzLfoAV79zid4fH95Wz8n69elldb9OZJ6VMVGgWVu3lImxMyuVlIzSVlQ1E7lus5pUmWYFhfF7Reu8IJpqaHUjmoIKSnS-RDdz7s67rwFC5J0bvB1P8qxqqhFYXTWjis4q6V0IHjTfebMV_sgp4RNk3vERMp8g8xny6LmbPTDW3xvwPEgDVoIyHmTkypl_3D-iPIfe</recordid><startdate>20220515</startdate><enddate>20220515</enddate><creator>Wang, Yuting</creator><creator>Chen, Jia</creator><creator>Wang, Ganping</creator><creator>Yu, Yongliang</creator><creator>Wang, Jianhua</creator><creator>Qiu, Hongdeng</creator><general>Elsevier B.V</general><general>Elsevier Science Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20220515</creationdate><title>Fluorescent determination of cysteine and homocysteine via adjustable synthesis of flower-shaped covalent organic frameworks</title><author>Wang, Yuting ; Chen, Jia ; Wang, Ganping ; Yu, Yongliang ; Wang, Jianhua ; Qiu, Hongdeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c325t-def7b8b17a43675dcc711ba687a3fb28062f741e202d18340f1febf9a941a10f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acetic acid</topic><topic>Benzene</topic><topic>Bio-thiol detection</topic><topic>Biomarkers</topic><topic>Cell lysate</topic><topic>Controllable preparation</topic><topic>Covalent organic frameworks</topic><topic>Crystal structure</topic><topic>Crystallinity</topic><topic>Cysteine</topic><topic>Flowers</topic><topic>Fluorescence</topic><topic>Fluorescent materials</topic><topic>Homocysteine</topic><topic>Morphology</topic><topic>Reaction time</topic><topic>Room temperature</topic><topic>Synthesis</topic><topic>Thermal stability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yuting</creatorcontrib><creatorcontrib>Chen, Jia</creatorcontrib><creatorcontrib>Wang, Ganping</creatorcontrib><creatorcontrib>Yu, Yongliang</creatorcontrib><creatorcontrib>Wang, Jianhua</creatorcontrib><creatorcontrib>Qiu, Hongdeng</creatorcontrib><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Sensors and actuators. B, Chemical</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yuting</au><au>Chen, Jia</au><au>Wang, Ganping</au><au>Yu, Yongliang</au><au>Wang, Jianhua</au><au>Qiu, Hongdeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fluorescent determination of cysteine and homocysteine via adjustable synthesis of flower-shaped covalent organic frameworks</atitle><jtitle>Sensors and actuators. B, Chemical</jtitle><date>2022-05-15</date><risdate>2022</risdate><volume>359</volume><spage>131555</spage><pages>131555-</pages><artnum>131555</artnum><issn>0925-4005</issn><eissn>1873-3077</eissn><abstract>Detection of cysteine (Cys) and homocysteine (Hcy) is very important for the early diagnosis and prevention of related diseases. Herein, we propose a facile, green, room-temperature controllable approach for the synthesis of fluorescent covalent organic frameworks (COFs) with high specific surface areas, high crystallinity, good morphology, excellent chemical and thermal stability by using 2,5-dimethoxyterephthaldehyde and 1,3,5-tris(4-aminophenyl)benzene as precursors. Interestingly, we found that the size and morphology of COFs could be controlled by the amount of acetic acid. With increasing numbers of acetic acid (HAc) molecules, the morphology of COFs gradually changed from spherical to flower-shaped, and the particle size gradually decreased from micrometer to nanometer. Furthermore, we were surprised to find that the reaction time influenced the uniform dispersion and crystallinity of flower-shaped COFs. With increasing the reaction time, the boundary around COFs became blurred, hierarchical flower-shaped COFs gradually appeared, and the flower-shaped gradually became clear and uniform. On this basis, the flower-shaped COFs were further used for highly sensitive determination of Cys and Hcy, with detection limits as low as 11.4 nM and 6.7 nM, respectively. The possible quenching mechanism was deduced by the Dmol3 package provided by Materials Studio and DFT calculations of Gaussian 09 software. This strategy could provide us a new insight into the controllable preparation of flower-shaped fluorescent COFs and broaden the application range of COFs for biomarker detection.
•Fluorescent COFs was prepared by a facile, green, room-temperature controllable approach.•The size and morphology of COFs could be controlled by the amount of acetic acid.•Uniform dispersion and crystallinity of flower-shaped COFs can be influenced by reaction time.•Highly sensitive determination of cysteine and homocysteine was obtained.</abstract><cop>Lausanne</cop><pub>Elsevier B.V</pub><doi>10.1016/j.snb.2022.131555</doi></addata></record> |
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| subjects | Acetic acid Benzene Bio-thiol detection Biomarkers Cell lysate Controllable preparation Covalent organic frameworks Crystal structure Crystallinity Cysteine Flowers Fluorescence Fluorescent materials Homocysteine Morphology Reaction time Room temperature Synthesis Thermal stability |
| title | Fluorescent determination of cysteine and homocysteine via adjustable synthesis of flower-shaped covalent organic frameworks |
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