Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway

There is evidence that environmental and genetic risk factors for schizophrenia spectrum disorders are transdiagnostic and mediated in part through a generic pathway of affective dysregulation. We analysed to what degree the impact of schizophrenia polygenic risk (PRS-SZ) and childhood adversity (CA...

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Veröffentlicht in:	Psychological medicine 2022-07, Vol.52 (10), p.1910-1922
Hauptverfasser:	van Os, Jim, Pries, Lotta-Katrin, ten Have, Margreet, de Graaf, Ron, van Dorsselaer, Saskia, Delespaul, Philippe, Bak, Maarten, Kenis, Gunter, Lin, Bochao D., Luykx, Jurjen J., Richards, Alexander L., Akdede, Berna, Binbay, Tolga, Altınyazar, Vesile, Yalınçetin, Berna, Gümüş-Akay, Güvem, Cihan, Burçin, Soygür, Haldun, Ulaş, Halis, Cankurtaran, Eylem Şahin, Kaymak, Semra Ulusoy, Mihaljevic, Marina M., Petrovic, Sanja Andric, Mirjanic, Tijana, Bernardo, Miguel, Mezquida, Gisela, Amoretti, Silvia, Bobes, Julio, Saiz, Pilar A., García-Portilla, María Paz, Sanjuan, Julio, Aguilar, Eduardo J., Santos, José Luis, Jiménez-López, Estela, Arrojo, Manuel, Carracedo, Angel, López, Gonzalo, González-Peñas, Javier, Parellada, Mara, Maric, Nadja P., Atbaşoğlu, Cem, Ucok, Alp, Alptekin, Köksal, Saka, Meram Can, Arango, Celso, O'Donovan, Michael, Rutten, Bart P. F., Guloksuz, Sinan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adversity Childhood Children Consent Delusions Delusions - diagnosis Genetic susceptibility Genomics Hallucinations Hallucinations - etiology Hallucinations - genetics Humans Ideation Mediation Medical ethics Mental depression Mental disorders Mental health Multifactorial Inheritance Neurosciences Online instruction Original Article Population Psychosis Psychotic Disorders - etiology Psychotic Disorders - genetics Replication Risk Risk factors Schizophrenia Schizophrenia - etiology Schizophrenia - genetics Siblings
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