A multicenter phase 1 study of PX-866 and cetuximab in patients with metastatic colorectal carcinoma or recurrent/metastatic squamous cell carcinoma of the head and neck

Summary Background This phase I, dose-finding study determined the safety, maximum tolerated dose (MTD)/recommended phase 2 dose (RP2D), and antitumor activity of PX-866, a phosphatidylinositol 3-kinase inhibitor, combined with cetuximab in patients with incurable colorectal cancer or squamous cell...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Investigational new drugs 2014-12, Vol.32 (6), p.1197-1203
Hauptverfasser:	Bowles, Daniel W., Senzer, Neil, Hausman, Diana, Peterson, Scott, Vo, Alex, Walker, Luke, Cohen, Roger B., Jimeno, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - adverse effects Antibodies, Monoclonal, Humanized - blood Antibodies, Monoclonal, Humanized - pharmacokinetics Anticancer properties Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Antitumor activity Antitumor agents Biological and medical sciences Cancer Cancer therapies Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Cetuximab Class I Phosphatidylinositol 3-Kinases Clinical trials Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Diarrhea Disease-Free Survival Dose-Response Relationship, Drug Drug dosages Drug therapy Edema Enzyme inhibitors Epidermal growth factor Female Gastroenterology. Liver. Pancreas. Abdomen Gonanes - administration & dosage Gonanes - adverse effects Head & neck cancer Head and neck carcinoma Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Humans Hypomagnesemia Kinases Male Maximum Tolerated Dose Medical sciences Medicine Medicine & Public Health Metastases Metastasis Middle Aged Monoclonal antibodies Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Mutation Nausea Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - metabolism Oncology Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Patient safety Patients Pharmaceuticals Pharmacology. Drug treatments Pharmacology/Toxicology Phase I Studies Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - genetics Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins p21(ras) ras Proteins - genetics Response Evaluation Criteria in Solid Tumors Signal transduction Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Studies Targeted cancer therapy Toxicity Tumors Vomiting
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!