A first-in-human phase I trial of LY2780301, a dual p70 S6 kinase and Akt Inhibitor, in patients with advanced or metastatic cancer

Summary The primary objective of this phase I study of LY2780301, a dual p70 S6 kinase and Akt inhibitor, was to determine the recommended phase II dose as a single agent in patients with advanced cancer. Secondary objectives included safety, pharmacokinetic, and pharmacodynamic analyses, and co-cli...

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Veröffentlicht in:	Investigational new drugs 2015-06, Vol.33 (3), p.710-719
Hauptverfasser:	Azaro, Analia, Rodon, Jordi, Calles, Antonio, Braña, Irene, Hidalgo, Manuel, Lopez-Casas, Pedro P., Munoz, Manuel, Westwood, Paul, Miller, Joel, Moser, Brian A., Ohnmacht, Ute, Bumgardner, William, Benhadji, Karim A., Calvo, Emiliano
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged AKT protein Alanine Alanine transaminase Anemia Animals Anticancer properties Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Antitumor activity Aspartate aminotransferase Biopsy Cancer Cancer therapies Cell cycle Cell growth Constipation Diarrhea Drug dosages Enzyme inhibitors Epidermis Female Health services Humans International Kinases Male Medical research Medicine Medicine & Public Health Metabolites Metastases Metastasis Mice, Nude Middle Aged Nausea Neoplasm Metastasis Neoplasm Staging Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - pathology Neutropenia Oncology p70 S6 kinase Patients Pharmaceutical industry Pharmacodynamics Pharmacokinetics Pharmacology Pharmacology/Toxicology Phase I Studies Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - pharmacokinetics Protein Kinase Inhibitors - therapeutic use Proteins Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism R&D Regulatory approval Research & development Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors Ribosomal Protein S6 Kinases, 70-kDa - metabolism Skin Studies Toxicity Transaminases Tumors Xenograft Model Antitumor Assays Young Adult γ-Glutamyltransferase
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