SMAC-armed vaccinia virus induces both apoptosis and necroptosis and synergizes the efficiency of vinblastine in HCC

Hepatocellular carcinoma (HCC) has particularly high incidence rate in Asia and its resistance to the chemotherapeutic drugs and cell death make it intractable. Vaccinia virus (VV) is a potential vehicle and has been widely used in cancer therapy. SMAC/DIABLO is a critical factor in activating caspa...

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Veröffentlicht in:	Human cell : official journal of Human Cell Research Society 2014-10, Vol.27 (4), p.162-171
Hauptverfasser:	Pan, Qiang, Huang, Yuanyong, Chen, Lieyang, Gu, JinFa, Zhou, Xiumei
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins Biomedical and Life Sciences Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - virology Caspase Cell Biology Cell death Cell Line, Tumor DIABLO protein Drug resistance Drug Synergism Gynecology Hepatocellular carcinoma Humans Intracellular Signaling Peptides and Proteins Kinases Life Sciences Liver Neoplasms - drug therapy Liver Neoplasms - pathology Liver Neoplasms - virology Mitochondrial Proteins Necroptosis Necrosis Oncology Reproductive Medicine Research Article Stem Cells Surgery Thymidine Thymidine kinase Thymidine Kinase - genetics Thymidine Kinase - pharmacology Thymidine Kinase - therapeutic use Tumors Vaccinia virus - enzymology Vaccinia virus - genetics Vinblastine Vinblastine - pharmacology Vinblastine - therapeutic use Viruses
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