Spontaneous reports on drug-induced pancreatitis in denmark from 1968 to 1999
To present an update on drug-induced pancreatitis reported to the Danish Committee on Adverse Drug Reactions. Retrospective study of spontaneous case reports to the Danish reporting system on adverse drug reactions. All cases of suspected drug-induced pancreatitis reported to the Danish Committee on...
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| Veröffentlicht in: | European journal of clinical pharmacology 2001-09, Vol.57 (6-7), p.517-521 |
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| creator | ANDERSEN, Vibeke SONNE, Jesper ANDERSEN, Morten |
| description | To present an update on drug-induced pancreatitis reported to the Danish Committee on Adverse Drug Reactions.
Retrospective study of spontaneous case reports to the Danish reporting system on adverse drug reactions.
All cases of suspected drug-induced pancreatitis reported to the Danish Committee on Adverse Drug Reactions from 1968 to 1999 were analysed. Three cases were excluded leaving 47 cases for analysis.
Drug-induced pancreatitis made up 0. 1% of all the reports to the committee from 1968 to 1999. The proportion seemed to increase and was 0.3% during the last 8 years. The 47 cases corresponded to 0.1% of the number of patients discharged due to pancreatic disease (without cancers) per year in Denmark. Serious courses were frequent as indicated by death and hospitalisation being reported in 4 (9%) and 32 (68%) cases, respectively. Death occurred after valproate (two cases), clomipramine (one case) and azathioprine (one case). Definite relationship was stated for mesalazine (three cases), azathioprine (two cases) and simvastatin (one case) on the basis of re-challenge. A possible or probable causality was considered for a further 30 drugs including 5-acetylsalicylic acid agents, angiotensin-converting enzyme inhibitors, estrogen preparations, didanosine, valproate, codeine, antiviral agents used in acquired immunodeficiency syndrome therapy, various lipid-reducing agents, interferon, paracetamol, griseofulvin, ticlopine, allopurinol, lithium and the MMR (measles" mumps/rubella) vaccination.
Drug-induced pancreatitis is rarely reported. The incidence may be increasing and the course is often serious. This is the first report on definite simvastatin-induced pancreatitis. Further studies on the pancreotoxic potential of drugs are warranted. |
| doi_str_mv | 10.1007/s002280100346 |
| format | Article |
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Retrospective study of spontaneous case reports to the Danish reporting system on adverse drug reactions.
All cases of suspected drug-induced pancreatitis reported to the Danish Committee on Adverse Drug Reactions from 1968 to 1999 were analysed. Three cases were excluded leaving 47 cases for analysis.
Drug-induced pancreatitis made up 0. 1% of all the reports to the committee from 1968 to 1999. The proportion seemed to increase and was 0.3% during the last 8 years. The 47 cases corresponded to 0.1% of the number of patients discharged due to pancreatic disease (without cancers) per year in Denmark. Serious courses were frequent as indicated by death and hospitalisation being reported in 4 (9%) and 32 (68%) cases, respectively. Death occurred after valproate (two cases), clomipramine (one case) and azathioprine (one case). Definite relationship was stated for mesalazine (three cases), azathioprine (two cases) and simvastatin (one case) on the basis of re-challenge. A possible or probable causality was considered for a further 30 drugs including 5-acetylsalicylic acid agents, angiotensin-converting enzyme inhibitors, estrogen preparations, didanosine, valproate, codeine, antiviral agents used in acquired immunodeficiency syndrome therapy, various lipid-reducing agents, interferon, paracetamol, griseofulvin, ticlopine, allopurinol, lithium and the MMR (measles" mumps/rubella) vaccination.
Drug-induced pancreatitis is rarely reported. The incidence may be increasing and the course is often serious. This is the first report on definite simvastatin-induced pancreatitis. Further studies on the pancreotoxic potential of drugs are warranted.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/s002280100346</identifier><identifier>PMID: 11699619</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Acetylsalicylic acid ; Acquired immune deficiency syndrome ; Adverse Drug Reaction Reporting Systems - statistics & numerical data ; Aged ; AIDS ; Allopurinol ; Angiotensin ; Angiotensin-converting enzyme inhibitors ; Antiviral agents ; Azathioprine ; Biological and medical sciences ; Case reports ; Clomipramine ; Codeine ; Committees ; Consumer protection ; Denmark ; Didanosine ; Drug development ; Drug Monitoring - statistics & numerical data ; Drug therapy ; Drug toxicity and drugs side effects treatment ; Drug-Related Side Effects and Adverse Reactions ; Estrogens ; Female ; Griseofulvin ; Humans ; Immunodeficiency ; Interferon ; Lithium ; Male ; Medical sciences ; Pancreas - drug effects ; Pancreas - pathology ; Pancreatic diseases ; Pancreatitis ; Pancreatitis - chemically induced ; Paracetamol ; Peptidyl-dipeptidase A ; Pharmaceutical industry ; Pharmacology. Drug treatments ; Reducing agents ; Side effects ; Simvastatin ; Toxicity: digestive system ; Vaccination ; Valproic acid</subject><ispartof>European journal of clinical pharmacology, 2001-09, Vol.57 (6-7), p.517-521</ispartof><rights>2001 INIST-CNRS</rights><rights>Springer-Verlag 2001</rights><rights>Springer-Verlag 2001.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-32341b61c98c13eb06527edf7365cbcd41ca8f7cea9ab8e759c198efdbdc3e5d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1116020$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11699619$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ANDERSEN, Vibeke</creatorcontrib><creatorcontrib>SONNE, Jesper</creatorcontrib><creatorcontrib>ANDERSEN, Morten</creatorcontrib><title>Spontaneous reports on drug-induced pancreatitis in denmark from 1968 to 1999</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>To present an update on drug-induced pancreatitis reported to the Danish Committee on Adverse Drug Reactions.
Retrospective study of spontaneous case reports to the Danish reporting system on adverse drug reactions.
All cases of suspected drug-induced pancreatitis reported to the Danish Committee on Adverse Drug Reactions from 1968 to 1999 were analysed. Three cases were excluded leaving 47 cases for analysis.
Drug-induced pancreatitis made up 0. 1% of all the reports to the committee from 1968 to 1999. The proportion seemed to increase and was 0.3% during the last 8 years. The 47 cases corresponded to 0.1% of the number of patients discharged due to pancreatic disease (without cancers) per year in Denmark. Serious courses were frequent as indicated by death and hospitalisation being reported in 4 (9%) and 32 (68%) cases, respectively. Death occurred after valproate (two cases), clomipramine (one case) and azathioprine (one case). Definite relationship was stated for mesalazine (three cases), azathioprine (two cases) and simvastatin (one case) on the basis of re-challenge. A possible or probable causality was considered for a further 30 drugs including 5-acetylsalicylic acid agents, angiotensin-converting enzyme inhibitors, estrogen preparations, didanosine, valproate, codeine, antiviral agents used in acquired immunodeficiency syndrome therapy, various lipid-reducing agents, interferon, paracetamol, griseofulvin, ticlopine, allopurinol, lithium and the MMR (measles" mumps/rubella) vaccination.
Drug-induced pancreatitis is rarely reported. The incidence may be increasing and the course is often serious. This is the first report on definite simvastatin-induced pancreatitis. Further studies on the pancreotoxic potential of drugs are warranted.</description><subject>Acetylsalicylic acid</subject><subject>Acquired immune deficiency syndrome</subject><subject>Adverse Drug Reaction Reporting Systems - statistics & numerical data</subject><subject>Aged</subject><subject>AIDS</subject><subject>Allopurinol</subject><subject>Angiotensin</subject><subject>Angiotensin-converting enzyme inhibitors</subject><subject>Antiviral agents</subject><subject>Azathioprine</subject><subject>Biological and medical sciences</subject><subject>Case reports</subject><subject>Clomipramine</subject><subject>Codeine</subject><subject>Committees</subject><subject>Consumer protection</subject><subject>Denmark</subject><subject>Didanosine</subject><subject>Drug development</subject><subject>Drug Monitoring - statistics & numerical data</subject><subject>Drug therapy</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Drug-Related Side Effects and Adverse Reactions</subject><subject>Estrogens</subject><subject>Female</subject><subject>Griseofulvin</subject><subject>Humans</subject><subject>Immunodeficiency</subject><subject>Interferon</subject><subject>Lithium</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pancreas - drug effects</subject><subject>Pancreas - pathology</subject><subject>Pancreatic diseases</subject><subject>Pancreatitis</subject><subject>Pancreatitis - chemically induced</subject><subject>Paracetamol</subject><subject>Peptidyl-dipeptidase A</subject><subject>Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Reducing agents</subject><subject>Side effects</subject><subject>Simvastatin</subject><subject>Toxicity: digestive system</subject><subject>Vaccination</subject><subject>Valproic acid</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kM1LxDAQxYMo7rp69CoBvVYzSZuPoyx-wYoH9VzSJJWuu01N0oP_vZEtqBdPb5j58R7zEDoFcgmEiKtICKWS5JmVfA_NoWS0AFLCPprnHRRcCTJDRzGuCYFKEXaIZgBcKQ5qjh6fB98n3Ts_Rhzc4EOK2PfYhvGt6Ho7GmfxoHsTnE5d6iLu8tH1Wx3ecRv8FoPiEiefValjdNDqTXQnky7Q6-3Ny_K-WD3dPSyvV4VhokwFo6yEhoNR0gBzDeEVFc62gvHKNMaWYLRshXFa6UY6USkDSrrWNtYwV1m2QOc73yH4j9HFVK_9GPocWVOuSkFzDP-PAip5TpMUMlXsKBN8jMG19RC6_N5nDaT-rrj-U3HmzybXsdk6-0NPnWbgYgJ0NHrThtxeF39xwAkl7As6X4Dc</recordid><startdate>20010901</startdate><enddate>20010901</enddate><creator>ANDERSEN, Vibeke</creator><creator>SONNE, Jesper</creator><creator>ANDERSEN, Morten</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20010901</creationdate><title>Spontaneous reports on drug-induced pancreatitis in denmark from 1968 to 1999</title><author>ANDERSEN, Vibeke ; SONNE, Jesper ; ANDERSEN, Morten</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-32341b61c98c13eb06527edf7365cbcd41ca8f7cea9ab8e759c198efdbdc3e5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Acetylsalicylic acid</topic><topic>Acquired immune deficiency syndrome</topic><topic>Adverse Drug Reaction Reporting Systems - statistics & numerical data</topic><topic>Aged</topic><topic>AIDS</topic><topic>Allopurinol</topic><topic>Angiotensin</topic><topic>Angiotensin-converting enzyme inhibitors</topic><topic>Antiviral agents</topic><topic>Azathioprine</topic><topic>Biological and medical sciences</topic><topic>Case reports</topic><topic>Clomipramine</topic><topic>Codeine</topic><topic>Committees</topic><topic>Consumer protection</topic><topic>Denmark</topic><topic>Didanosine</topic><topic>Drug development</topic><topic>Drug Monitoring - statistics & numerical data</topic><topic>Drug therapy</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Drug-Related Side Effects and Adverse Reactions</topic><topic>Estrogens</topic><topic>Female</topic><topic>Griseofulvin</topic><topic>Humans</topic><topic>Immunodeficiency</topic><topic>Interferon</topic><topic>Lithium</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pancreas - drug effects</topic><topic>Pancreas - pathology</topic><topic>Pancreatic diseases</topic><topic>Pancreatitis</topic><topic>Pancreatitis - chemically induced</topic><topic>Paracetamol</topic><topic>Peptidyl-dipeptidase A</topic><topic>Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Reducing agents</topic><topic>Side effects</topic><topic>Simvastatin</topic><topic>Toxicity: digestive system</topic><topic>Vaccination</topic><topic>Valproic acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ANDERSEN, Vibeke</creatorcontrib><creatorcontrib>SONNE, Jesper</creatorcontrib><creatorcontrib>ANDERSEN, Morten</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ANDERSEN, Vibeke</au><au>SONNE, Jesper</au><au>ANDERSEN, Morten</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneous reports on drug-induced pancreatitis in denmark from 1968 to 1999</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>2001-09-01</date><risdate>2001</risdate><volume>57</volume><issue>6-7</issue><spage>517</spage><epage>521</epage><pages>517-521</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>To present an update on drug-induced pancreatitis reported to the Danish Committee on Adverse Drug Reactions.
Retrospective study of spontaneous case reports to the Danish reporting system on adverse drug reactions.
All cases of suspected drug-induced pancreatitis reported to the Danish Committee on Adverse Drug Reactions from 1968 to 1999 were analysed. Three cases were excluded leaving 47 cases for analysis.
Drug-induced pancreatitis made up 0. 1% of all the reports to the committee from 1968 to 1999. The proportion seemed to increase and was 0.3% during the last 8 years. The 47 cases corresponded to 0.1% of the number of patients discharged due to pancreatic disease (without cancers) per year in Denmark. Serious courses were frequent as indicated by death and hospitalisation being reported in 4 (9%) and 32 (68%) cases, respectively. Death occurred after valproate (two cases), clomipramine (one case) and azathioprine (one case). Definite relationship was stated for mesalazine (three cases), azathioprine (two cases) and simvastatin (one case) on the basis of re-challenge. A possible or probable causality was considered for a further 30 drugs including 5-acetylsalicylic acid agents, angiotensin-converting enzyme inhibitors, estrogen preparations, didanosine, valproate, codeine, antiviral agents used in acquired immunodeficiency syndrome therapy, various lipid-reducing agents, interferon, paracetamol, griseofulvin, ticlopine, allopurinol, lithium and the MMR (measles" mumps/rubella) vaccination.
Drug-induced pancreatitis is rarely reported. The incidence may be increasing and the course is often serious. This is the first report on definite simvastatin-induced pancreatitis. Further studies on the pancreotoxic potential of drugs are warranted.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>11699619</pmid><doi>10.1007/s002280100346</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-6970 |
| ispartof | European journal of clinical pharmacology, 2001-09, Vol.57 (6-7), p.517-521 |
| issn | 0031-6970 1432-1041 |
| language | eng |
| recordid | cdi_proquest_journals_2694723746 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Acetylsalicylic acid Acquired immune deficiency syndrome Adverse Drug Reaction Reporting Systems - statistics & numerical data Aged AIDS Allopurinol Angiotensin Angiotensin-converting enzyme inhibitors Antiviral agents Azathioprine Biological and medical sciences Case reports Clomipramine Codeine Committees Consumer protection Denmark Didanosine Drug development Drug Monitoring - statistics & numerical data Drug therapy Drug toxicity and drugs side effects treatment Drug-Related Side Effects and Adverse Reactions Estrogens Female Griseofulvin Humans Immunodeficiency Interferon Lithium Male Medical sciences Pancreas - drug effects Pancreas - pathology Pancreatic diseases Pancreatitis Pancreatitis - chemically induced Paracetamol Peptidyl-dipeptidase A Pharmaceutical industry Pharmacology. Drug treatments Reducing agents Side effects Simvastatin Toxicity: digestive system Vaccination Valproic acid |
| title | Spontaneous reports on drug-induced pancreatitis in denmark from 1968 to 1999 |
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