Bergenin from Bergenia Species Produces a Protective Response against Myocardial Infarction in Rats
Bergenin is a phenolic glycoside that has been reported to occur naturally in several plant species, reported as a cardioprotective. However, bergenin, one of the important phytochemicals in these plants, is still not reported as a cardioprotective. The present study was designed to investigate the...
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| Veröffentlicht in: | Processes 2022-07, Vol.10 (7), p.1403 |
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| creator | Ahmad, Taseer Haq, Imran Ul Khan, Taous Mahnashi, Mater H. Alasmary, Mohammed Y. Almedhesh, Sultan A. Shehri, Hamdan Al Alshahrani, Mohammed A. Shah, Abdul Jabbar |
| description | Bergenin is a phenolic glycoside that has been reported to occur naturally in several plant species, reported as a cardioprotective. However, bergenin, one of the important phytochemicals in these plants, is still not reported as a cardioprotective. The present study was designed to investigate the cardioprotective effects of bergenin on isoproterenol-induced myocardial infarction in rats. Bergenin and atenolol were administered through intraperitoneal (i.p.) injection to Sprague Dawley (SD) rats in separate experiments for five (5) days. At the end of this period, rats were administered isoproterenol (80 mg/kg s.c.) to induce myocardial injury. After induction, rats were anaesthetized to record lead II ECG, then sacrificed, blood was collected to analyze cardiac marker enzymes, and a histopathological study of the heart tissues was also performed. Pretreatment with bergenin showed a significant decrease in ST-segment elevation, deep Q-wave, infarct size, and also normalized cardiac marker enzymes (cTnI, CPK, CK-MB, LDH, ALT, and AST), particularly at 3 mg/kg, as compared to isoproterenol treated group. Our findings revealed, for the first time, the use of glycoside bergenin as a potential cardioprotective agent against the isoproterenol-induced MI in rats. |
| doi_str_mv | 10.3390/pr10071403 |
| format | Article |
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However, bergenin, one of the important phytochemicals in these plants, is still not reported as a cardioprotective. The present study was designed to investigate the cardioprotective effects of bergenin on isoproterenol-induced myocardial infarction in rats. Bergenin and atenolol were administered through intraperitoneal (i.p.) injection to Sprague Dawley (SD) rats in separate experiments for five (5) days. At the end of this period, rats were administered isoproterenol (80 mg/kg s.c.) to induce myocardial injury. After induction, rats were anaesthetized to record lead II ECG, then sacrificed, blood was collected to analyze cardiac marker enzymes, and a histopathological study of the heart tissues was also performed. Pretreatment with bergenin showed a significant decrease in ST-segment elevation, deep Q-wave, infarct size, and also normalized cardiac marker enzymes (cTnI, CPK, CK-MB, LDH, ALT, and AST), particularly at 3 mg/kg, as compared to isoproterenol treated group. Our findings revealed, for the first time, the use of glycoside bergenin as a potential cardioprotective agent against the isoproterenol-induced MI in rats.</description><identifier>ISSN: 2227-9717</identifier><identifier>EISSN: 2227-9717</identifier><identifier>DOI: 10.3390/pr10071403</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Atenolol ; Biomarkers ; Edema ; EKG ; Enzymes ; Glycosides ; Heart ; Heart attacks ; Inflammation ; Ischemia ; Isoproterenol ; Markers ; Myocardial infarction ; Phenolic compounds</subject><ispartof>Processes, 2022-07, Vol.10 (7), p.1403</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c295t-2e694b016804c0dc2979fbad9bbe153250d8c48c0f117f39f6ff765993407f6b3</citedby><cites>FETCH-LOGICAL-c295t-2e694b016804c0dc2979fbad9bbe153250d8c48c0f117f39f6ff765993407f6b3</cites><orcidid>0000-0001-6806-4324 ; 0000-0003-3495-3152</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27913,27914</link.rule.ids></links><search><creatorcontrib>Ahmad, Taseer</creatorcontrib><creatorcontrib>Haq, Imran Ul</creatorcontrib><creatorcontrib>Khan, Taous</creatorcontrib><creatorcontrib>Mahnashi, Mater H.</creatorcontrib><creatorcontrib>Alasmary, Mohammed Y.</creatorcontrib><creatorcontrib>Almedhesh, Sultan A.</creatorcontrib><creatorcontrib>Shehri, Hamdan Al</creatorcontrib><creatorcontrib>Alshahrani, Mohammed A.</creatorcontrib><creatorcontrib>Shah, Abdul Jabbar</creatorcontrib><title>Bergenin from Bergenia Species Produces a Protective Response against Myocardial Infarction in Rats</title><title>Processes</title><description>Bergenin is a phenolic glycoside that has been reported to occur naturally in several plant species, reported as a cardioprotective. 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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute |
| subjects | Atenolol Biomarkers Edema EKG Enzymes Glycosides Heart Heart attacks Inflammation Ischemia Isoproterenol Markers Myocardial infarction Phenolic compounds |
| title | Bergenin from Bergenia Species Produces a Protective Response against Myocardial Infarction in Rats |
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