Modeling of the Interaction of Cytochrome c with the Lipid Bilayer
— Interactions of horse heart cytochrome c (Cyt c ) with the lipid bilayer consisting of tetraoleoyl cardiolipin molecules were studied by molecular dynamics simulations. It was shown that the Cyt c molecule can penetrate this lipid bilayer. The steps of this process and conformational changes of th...
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| Veröffentlicht in: | Crystallography reports 2022-08, Vol.67 (4), p.590-593 |
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| container_title | Crystallography reports |
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| creator | Korotkova, P. D. Yurchenko, A. A. Timofeev, V. I. Podshivalov, D. D. Gusel’nikova, A. R. Shumm, A. B. Vladimirov, Y. A. |
| description | —
Interactions of horse heart cytochrome
c
(Cyt
c
) with the lipid bilayer consisting of tetraoleoyl cardiolipin molecules were studied by molecular dynamics simulations. It was shown that the Cyt
c
molecule can penetrate this lipid bilayer. The steps of this process and conformational changes of the Cyt
c
molecule upon interaction with the bilayer are described. These data can provide better insight into the molecular mechanism of apoptosis. |
| doi_str_mv | 10.1134/S1063774522030117 |
| format | Article |
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Interactions of horse heart cytochrome
c
(Cyt
c
) with the lipid bilayer consisting of tetraoleoyl cardiolipin molecules were studied by molecular dynamics simulations. It was shown that the Cyt
c
molecule can penetrate this lipid bilayer. The steps of this process and conformational changes of the Cyt
c
molecule upon interaction with the bilayer are described. These data can provide better insight into the molecular mechanism of apoptosis.</description><identifier>ISSN: 1063-7745</identifier><identifier>EISSN: 1562-689X</identifier><identifier>DOI: 10.1134/S1063774522030117</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Apoptosis ; Crystallography and Scattering Methods ; Cytochromes ; Lipids ; Molecular dynamics ; Physics ; Physics and Astronomy ; Structure of Macromolecular Compounds</subject><ispartof>Crystallography reports, 2022-08, Vol.67 (4), p.590-593</ispartof><rights>Pleiades Publishing, Inc. 2022. ISSN 1063-7745, Crystallography Reports, 2022, Vol. 67, No. 4, pp. 590–593. © Pleiades Publishing, Inc., 2022. Russian Text © The Author(s), 2022, published in Kristallografiya, 2022, Vol. 67, No. 4, pp. 632–635.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c268t-d0dd72ab7214be8bbb049d0f0b9a798f1730bd80ac7401d11fe2f6fee90f3e323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1063774522030117$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1063774522030117$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Korotkova, P. D.</creatorcontrib><creatorcontrib>Yurchenko, A. A.</creatorcontrib><creatorcontrib>Timofeev, V. I.</creatorcontrib><creatorcontrib>Podshivalov, D. D.</creatorcontrib><creatorcontrib>Gusel’nikova, A. R.</creatorcontrib><creatorcontrib>Shumm, A. B.</creatorcontrib><creatorcontrib>Vladimirov, Y. A.</creatorcontrib><title>Modeling of the Interaction of Cytochrome c with the Lipid Bilayer</title><title>Crystallography reports</title><addtitle>Crystallogr. Rep</addtitle><description>—
Interactions of horse heart cytochrome
c
(Cyt
c
) with the lipid bilayer consisting of tetraoleoyl cardiolipin molecules were studied by molecular dynamics simulations. It was shown that the Cyt
c
molecule can penetrate this lipid bilayer. The steps of this process and conformational changes of the Cyt
c
molecule upon interaction with the bilayer are described. These data can provide better insight into the molecular mechanism of apoptosis.</description><subject>Apoptosis</subject><subject>Crystallography and Scattering Methods</subject><subject>Cytochromes</subject><subject>Lipids</subject><subject>Molecular dynamics</subject><subject>Physics</subject><subject>Physics and Astronomy</subject><subject>Structure of Macromolecular Compounds</subject><issn>1063-7745</issn><issn>1562-689X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kE9LAzEQxYMoWKsfwNuC59WZZLtJjrb4p1DxoIK3JdkkbUq7qUmK9Nu7tYIH8TTDvN97A4-QS4RrRFbdvCDUjPNqRCkwQORHZICjmpa1kO_H_d7L5V4_JWcpLQFACKwGZPwUjF35bl4EV-SFLaZdtlG12Yduf5rscmgXMaxt0RafPi--oZnfeFOM_UrtbDwnJ06tkr34mUPydn_3OnksZ88P08ntrGxpLXJpwBhOleYUK22F1hoqacCBlopL4ZAz0EaAankFaBCdpa521kpwzDLKhuTqkLuJ4WNrU26WYRu7_mVDa8lAAqtYT-GBamNIKVrXbKJfq7hrEJp9Vc2fqnoPPXhSz3ZzG3-T_zd9AVZWadk</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Korotkova, P. D.</creator><creator>Yurchenko, A. A.</creator><creator>Timofeev, V. I.</creator><creator>Podshivalov, D. D.</creator><creator>Gusel’nikova, A. R.</creator><creator>Shumm, A. B.</creator><creator>Vladimirov, Y. A.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20220801</creationdate><title>Modeling of the Interaction of Cytochrome c with the Lipid Bilayer</title><author>Korotkova, P. D. ; Yurchenko, A. A. ; Timofeev, V. I. ; Podshivalov, D. D. ; Gusel’nikova, A. R. ; Shumm, A. B. ; Vladimirov, Y. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c268t-d0dd72ab7214be8bbb049d0f0b9a798f1730bd80ac7401d11fe2f6fee90f3e323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Apoptosis</topic><topic>Crystallography and Scattering Methods</topic><topic>Cytochromes</topic><topic>Lipids</topic><topic>Molecular dynamics</topic><topic>Physics</topic><topic>Physics and Astronomy</topic><topic>Structure of Macromolecular Compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Korotkova, P. D.</creatorcontrib><creatorcontrib>Yurchenko, A. A.</creatorcontrib><creatorcontrib>Timofeev, V. I.</creatorcontrib><creatorcontrib>Podshivalov, D. D.</creatorcontrib><creatorcontrib>Gusel’nikova, A. R.</creatorcontrib><creatorcontrib>Shumm, A. B.</creatorcontrib><creatorcontrib>Vladimirov, Y. A.</creatorcontrib><collection>CrossRef</collection><jtitle>Crystallography reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Korotkova, P. D.</au><au>Yurchenko, A. A.</au><au>Timofeev, V. I.</au><au>Podshivalov, D. D.</au><au>Gusel’nikova, A. R.</au><au>Shumm, A. B.</au><au>Vladimirov, Y. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modeling of the Interaction of Cytochrome c with the Lipid Bilayer</atitle><jtitle>Crystallography reports</jtitle><stitle>Crystallogr. Rep</stitle><date>2022-08-01</date><risdate>2022</risdate><volume>67</volume><issue>4</issue><spage>590</spage><epage>593</epage><pages>590-593</pages><issn>1063-7745</issn><eissn>1562-689X</eissn><abstract>—
Interactions of horse heart cytochrome
c
(Cyt
c
) with the lipid bilayer consisting of tetraoleoyl cardiolipin molecules were studied by molecular dynamics simulations. It was shown that the Cyt
c
molecule can penetrate this lipid bilayer. The steps of this process and conformational changes of the Cyt
c
molecule upon interaction with the bilayer are described. These data can provide better insight into the molecular mechanism of apoptosis.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1063774522030117</doi><tpages>4</tpages></addata></record> |
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| ispartof | Crystallography reports, 2022-08, Vol.67 (4), p.590-593 |
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| language | eng |
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| source | SpringerLink Journals |
| subjects | Apoptosis Crystallography and Scattering Methods Cytochromes Lipids Molecular dynamics Physics Physics and Astronomy Structure of Macromolecular Compounds |
| title | Modeling of the Interaction of Cytochrome c with the Lipid Bilayer |
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