Serum spexin, adiponectin and leptin levels in polycystic ovarian syndrome in association with FTO gene polymorphism
Polycystic ovary syndrome (PCOS) is a complex reproductive endocrinopathy among reproductive-aged women and related with body mass and insulin resistance. Adipocytokines produced by adipose tissue seems to take part in the hormonal and metabolic alterations that arise in PCOS. Fat mass and obesity a...
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| Veröffentlicht in: | Ginekologia polska 2021-01, Vol.92 (10), p.682-688 |
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| creator | Beyazit, Fatma Hiz, Merve Meliha Turkon, Hakan Unsal, Mesut Abdulkerim |
| description | Polycystic ovary syndrome (PCOS) is a complex reproductive endocrinopathy among reproductive-aged women and related with body mass and insulin resistance. Adipocytokines produced by adipose tissue seems to take part in the hormonal and metabolic alterations that arise in PCOS. Fat mass and obesity associated (FTO) gene is linked with body mass index (BMI) and diabetes. Aims - To investigate the association between fat mass related adipocytokines and single nucleotide polymorphisms (SNPs) (rs9939609 T/A) in the FTO gene in women with PCOS. Study design - Cross-sectional study MATERIAL AND METHODS: FTO+rs9939609 gene polymorphism and serum spexin, adiponectin and leptin levels were determined in 91 PCOS women and 86 healthy controls. Study participants were subdivided according to BMI and comparisons were made within each group.
Serum spexin levels were not differed between study groups. Serum levels of adiponectin were found to be decreased in PCOS women with BMI lower than 25 kg/m2 (10.1 ± 5.6 vs 14.1 ± 9.1, p = 0.015). Serum leptin levels were elevated in obese PCOS women compared to healthy control group (2197.9 ± 596.3 pg/mL vs 1535.9 ± 812.1 pg/mL, p = 0.001). The prevalence of A risk allele of SNP rs9939609 was more frequent in PCOS patients than in the control group. PCOS risk was found to increase 3 times more in AA genotype when compared with TT genotype (OR = 3.04 95% CI: 1.243-7.309; p = 0.013).
Serum adiponectin and leptin levels may serve as independent markers for PCOS diagnosis. Moreover, the FTO+rs9939609 gene polymorphism increase susceptibility to PCOS development independent from serum adipocytokine levels. |
| doi_str_mv | 10.5603/GP.a2020.0176 |
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Serum spexin levels were not differed between study groups. Serum levels of adiponectin were found to be decreased in PCOS women with BMI lower than 25 kg/m2 (10.1 ± 5.6 vs 14.1 ± 9.1, p = 0.015). Serum leptin levels were elevated in obese PCOS women compared to healthy control group (2197.9 ± 596.3 pg/mL vs 1535.9 ± 812.1 pg/mL, p = 0.001). The prevalence of A risk allele of SNP rs9939609 was more frequent in PCOS patients than in the control group. PCOS risk was found to increase 3 times more in AA genotype when compared with TT genotype (OR = 3.04 95% CI: 1.243-7.309; p = 0.013).
Serum adiponectin and leptin levels may serve as independent markers for PCOS diagnosis. Moreover, the FTO+rs9939609 gene polymorphism increase susceptibility to PCOS development independent from serum adipocytokine levels.</description><identifier>ISSN: 0017-0011</identifier><identifier>EISSN: 2543-6767</identifier><identifier>DOI: 10.5603/GP.a2020.0176</identifier><identifier>PMID: 33914321</identifier><language>eng</language><publisher>Poland: Wydawnictwo Via Medica</publisher><subject>Adiponectin - blood ; Adult ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics ; Body Mass Index ; Case-Control Studies ; Cross-Sectional Studies ; Female ; Genotype ; Humans ; Insulin Resistance ; Leptin - blood ; Peptide Hormones - blood ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - genetics ; Polymorphism ; Polymorphism, Single Nucleotide</subject><ispartof>Ginekologia polska, 2021-01, Vol.92 (10), p.682-688</ispartof><rights>2021. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-f670bf46ef2ac588e98af9f5fdc2412091bd701ff8aba8d2eafca8e02e93989c3</citedby><orcidid>0000-0002-0667-609 ; 0000-0002-2766-5999 ; 0000-0003-1888-9322 ; 0000-0003-4303-9717</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33914321$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beyazit, Fatma</creatorcontrib><creatorcontrib>Hiz, Merve Meliha</creatorcontrib><creatorcontrib>Turkon, Hakan</creatorcontrib><creatorcontrib>Unsal, Mesut Abdulkerim</creatorcontrib><title>Serum spexin, adiponectin and leptin levels in polycystic ovarian syndrome in association with FTO gene polymorphism</title><title>Ginekologia polska</title><addtitle>Ginekol Pol</addtitle><description>Polycystic ovary syndrome (PCOS) is a complex reproductive endocrinopathy among reproductive-aged women and related with body mass and insulin resistance. Adipocytokines produced by adipose tissue seems to take part in the hormonal and metabolic alterations that arise in PCOS. Fat mass and obesity associated (FTO) gene is linked with body mass index (BMI) and diabetes. Aims - To investigate the association between fat mass related adipocytokines and single nucleotide polymorphisms (SNPs) (rs9939609 T/A) in the FTO gene in women with PCOS. Study design - Cross-sectional study MATERIAL AND METHODS: FTO+rs9939609 gene polymorphism and serum spexin, adiponectin and leptin levels were determined in 91 PCOS women and 86 healthy controls. Study participants were subdivided according to BMI and comparisons were made within each group.
Serum spexin levels were not differed between study groups. Serum levels of adiponectin were found to be decreased in PCOS women with BMI lower than 25 kg/m2 (10.1 ± 5.6 vs 14.1 ± 9.1, p = 0.015). Serum leptin levels were elevated in obese PCOS women compared to healthy control group (2197.9 ± 596.3 pg/mL vs 1535.9 ± 812.1 pg/mL, p = 0.001). The prevalence of A risk allele of SNP rs9939609 was more frequent in PCOS patients than in the control group. PCOS risk was found to increase 3 times more in AA genotype when compared with TT genotype (OR = 3.04 95% CI: 1.243-7.309; p = 0.013).
Serum adiponectin and leptin levels may serve as independent markers for PCOS diagnosis. Moreover, the FTO+rs9939609 gene polymorphism increase susceptibility to PCOS development independent from serum adipocytokine levels.</description><subject>Adiponectin - blood</subject><subject>Adult</subject><subject>Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics</subject><subject>Body Mass Index</subject><subject>Case-Control Studies</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Genotype</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Leptin - blood</subject><subject>Peptide Hormones - blood</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - genetics</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><issn>0017-0011</issn><issn>2543-6767</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNo9kMtLAzEQxoMottQevUrAq1vz2FeOUmwVCi1Yz0s2O7GR3WRNttX-924fepn5mPnmG_ghdEvJJEkJf5yvJpIRRiaEZukFGrIk5lGapdklGpJ-FvWFDtA4BFOSmDFBaSKu0YBzQWPO6BB1b-C3DQ4t_Bj7gGVlWmdBdcZiaStcQ3uQNeygDrhXrav3ah86o7DbSW-kxWFvK-8aOKxlCE4Z2Rln8bfpNni2XuIPsHA8bJxvNyY0N-hKyzrA-NxH6H32vJ6-RIvl_HX6tIgUT0kX6TQjpY5T0EyqJM9B5FILnehKsZgyImhZZYRqnctS5hUDqZXMgTAQXORC8RG6P-W23n1tIXTFp9t6278sWCpYxnPOae-KTi7lXQgedNF600i_LygpDpiL-ao4Yi4OmHv_3Tl1WzZQ_bv_oPJfjjh6qg</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Beyazit, Fatma</creator><creator>Hiz, Merve Meliha</creator><creator>Turkon, Hakan</creator><creator>Unsal, Mesut Abdulkerim</creator><general>Wydawnictwo Via Medica</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0002-0667-609</orcidid><orcidid>https://orcid.org/0000-0002-2766-5999</orcidid><orcidid>https://orcid.org/0000-0003-1888-9322</orcidid><orcidid>https://orcid.org/0000-0003-4303-9717</orcidid></search><sort><creationdate>20210101</creationdate><title>Serum spexin, adiponectin and leptin levels in polycystic ovarian syndrome in association with FTO gene polymorphism</title><author>Beyazit, Fatma ; Hiz, Merve Meliha ; Turkon, Hakan ; Unsal, Mesut Abdulkerim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-f670bf46ef2ac588e98af9f5fdc2412091bd701ff8aba8d2eafca8e02e93989c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adiponectin - blood</topic><topic>Adult</topic><topic>Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics</topic><topic>Body Mass Index</topic><topic>Case-Control Studies</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Genotype</topic><topic>Humans</topic><topic>Insulin Resistance</topic><topic>Leptin - blood</topic><topic>Peptide Hormones - blood</topic><topic>Polycystic ovary syndrome</topic><topic>Polycystic Ovary Syndrome - genetics</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beyazit, Fatma</creatorcontrib><creatorcontrib>Hiz, Merve Meliha</creatorcontrib><creatorcontrib>Turkon, Hakan</creatorcontrib><creatorcontrib>Unsal, Mesut Abdulkerim</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Ginekologia polska</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beyazit, Fatma</au><au>Hiz, Merve Meliha</au><au>Turkon, Hakan</au><au>Unsal, Mesut Abdulkerim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum spexin, adiponectin and leptin levels in polycystic ovarian syndrome in association with FTO gene polymorphism</atitle><jtitle>Ginekologia polska</jtitle><addtitle>Ginekol Pol</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>92</volume><issue>10</issue><spage>682</spage><epage>688</epage><pages>682-688</pages><issn>0017-0011</issn><eissn>2543-6767</eissn><abstract>Polycystic ovary syndrome (PCOS) is a complex reproductive endocrinopathy among reproductive-aged women and related with body mass and insulin resistance. Adipocytokines produced by adipose tissue seems to take part in the hormonal and metabolic alterations that arise in PCOS. Fat mass and obesity associated (FTO) gene is linked with body mass index (BMI) and diabetes. Aims - To investigate the association between fat mass related adipocytokines and single nucleotide polymorphisms (SNPs) (rs9939609 T/A) in the FTO gene in women with PCOS. Study design - Cross-sectional study MATERIAL AND METHODS: FTO+rs9939609 gene polymorphism and serum spexin, adiponectin and leptin levels were determined in 91 PCOS women and 86 healthy controls. Study participants were subdivided according to BMI and comparisons were made within each group.
Serum spexin levels were not differed between study groups. Serum levels of adiponectin were found to be decreased in PCOS women with BMI lower than 25 kg/m2 (10.1 ± 5.6 vs 14.1 ± 9.1, p = 0.015). Serum leptin levels were elevated in obese PCOS women compared to healthy control group (2197.9 ± 596.3 pg/mL vs 1535.9 ± 812.1 pg/mL, p = 0.001). The prevalence of A risk allele of SNP rs9939609 was more frequent in PCOS patients than in the control group. PCOS risk was found to increase 3 times more in AA genotype when compared with TT genotype (OR = 3.04 95% CI: 1.243-7.309; p = 0.013).
Serum adiponectin and leptin levels may serve as independent markers for PCOS diagnosis. Moreover, the FTO+rs9939609 gene polymorphism increase susceptibility to PCOS development independent from serum adipocytokine levels.</abstract><cop>Poland</cop><pub>Wydawnictwo Via Medica</pub><pmid>33914321</pmid><doi>10.5603/GP.a2020.0176</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0667-609</orcidid><orcidid>https://orcid.org/0000-0002-2766-5999</orcidid><orcidid>https://orcid.org/0000-0003-1888-9322</orcidid><orcidid>https://orcid.org/0000-0003-4303-9717</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adiponectin - blood Adult Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics Body Mass Index Case-Control Studies Cross-Sectional Studies Female Genotype Humans Insulin Resistance Leptin - blood Peptide Hormones - blood Polycystic ovary syndrome Polycystic Ovary Syndrome - genetics Polymorphism Polymorphism, Single Nucleotide |
| title | Serum spexin, adiponectin and leptin levels in polycystic ovarian syndrome in association with FTO gene polymorphism |
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