Reproducibility of ultrasound attenuation imaging for the noninvasive evaluation of hepatic steatosis
Purpose: The purpose of this study was to evaluate the intra-observer reproducibility of ultrasound attenuation imaging (ATI) for the noninvasive assessment of hepatic steatosis in patients with suspected hepatic steatosis and the inter-observer reproducibility in asymptomatic volunteers. Methods: T...
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| Veröffentlicht in: | Ultrasonography (Seoul, Korea) 2020, 39(2), , pp.121-129 |
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| creator | Yoo, Jeongin Lee, Jeong Min Joo, Ijin Lee, Dong Ho Yoon, Jeong Hee Kang, Hyo-Jin Ahn, Su Joa |
| description | Purpose: The purpose of this study was to evaluate the intra-observer reproducibility of ultrasound attenuation imaging (ATI) for the noninvasive assessment of hepatic steatosis in patients with suspected hepatic steatosis and the inter-observer reproducibility in asymptomatic volunteers.
Methods: This prospective study was approved by our institutional review board and informed consent was obtained from all patients. In group 1, composed of patients with suspected hepatic steatosis (n=143), one abdominal radiologist performed gray-scale ultrasonography and two sessions of ATI. In group 2, composed of healthy volunteers (n=18), three independent sessions of ATI were performed by three abdominal radiologists. The visual degree of hepatic steatosis in all study subjects was graded on a 4-point scale by two independent reviewers using gray-scale ultrasonography. Thereafter, the attenuation coefficient (AC) was correlated with the degree of hepatic steatosis using Spearman rank correlation analysis. Intra-class correlation coefficients (ICCs) were used to assess the intra-observer (group 1) and inter-observer reproducibility (group 2) of ATI measurements.
Results: For the intra-observer reproducibility of ATI, the ICC was 0.929 (95% confidence interval [CI], 0.901 to 0.949), and the coefficient of variation was 7.1%. Inter-observer reproducibility of ATI measurements showed an ICC of 0.792 (95% CI, 0.549 to 0.916). The AC showed a significant correlation with the visual grade of hepatic steatosis for both reviewers (rho, 0.780 and 0.695; P |
| doi_str_mv | 10.14366/usg.19034 |
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Methods: This prospective study was approved by our institutional review board and informed consent was obtained from all patients. In group 1, composed of patients with suspected hepatic steatosis (n=143), one abdominal radiologist performed gray-scale ultrasonography and two sessions of ATI. In group 2, composed of healthy volunteers (n=18), three independent sessions of ATI were performed by three abdominal radiologists. The visual degree of hepatic steatosis in all study subjects was graded on a 4-point scale by two independent reviewers using gray-scale ultrasonography. Thereafter, the attenuation coefficient (AC) was correlated with the degree of hepatic steatosis using Spearman rank correlation analysis. Intra-class correlation coefficients (ICCs) were used to assess the intra-observer (group 1) and inter-observer reproducibility (group 2) of ATI measurements.
Results: For the intra-observer reproducibility of ATI, the ICC was 0.929 (95% confidence interval [CI], 0.901 to 0.949), and the coefficient of variation was 7.1%. Inter-observer reproducibility of ATI measurements showed an ICC of 0.792 (95% CI, 0.549 to 0.916). The AC showed a significant correlation with the visual grade of hepatic steatosis for both reviewers (rho, 0.780 and 0.695; P<0.001, respectively).
Conclusion: ATI showed high intra- and inter-observer reproducibility in the assessment of hepatic steatosis.</description><identifier>ISSN: 2288-5919</identifier><identifier>EISSN: 2288-5943</identifier><identifier>DOI: 10.14366/usg.19034</identifier><identifier>PMID: 31693842</identifier><language>eng</language><publisher>SEOUL: Korean Soc Ultrasound Medicine</publisher><subject>Agreements ; Asymptomatic ; Biochemistry ; Biopsy ; Body mass index ; Hepatitis ; Laboratories ; Life Sciences & Biomedicine ; Liver diseases ; non-alcoholic fatty liver disease ; obesity ; Original ; Radiology, Nuclear Medicine & Medical Imaging ; Reproducibility ; Science & Technology ; Statistical analysis ; Ultrasonic imaging ; ultrasonography ; 방사선과학</subject><ispartof>ULTRASONOGRAPHY, 2020, 39(2), , pp.121-129</ispartof><rights>2020. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2020 Korean Society of Ultrasound in Medicine (KSUM) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>49</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000519927400003</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c572t-63e34bbbaf57f913253c1b9b1e15f1c79a888475351d249180c314faf078a1d03</citedby><cites>FETCH-LOGICAL-c572t-63e34bbbaf57f913253c1b9b1e15f1c79a888475351d249180c314faf078a1d03</cites><orcidid>0000-0002-1341-4072 ; 0000-0002-6771-2112 ; 0000-0001-8983-851X ; 0000-0002-3267-2544 ; 0000-0003-0561-8777 ; 0000-0002-9925-9973</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065988/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065988/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,27929,27930,28253,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31693842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002573969$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoo, Jeongin</creatorcontrib><creatorcontrib>Lee, Jeong Min</creatorcontrib><creatorcontrib>Joo, Ijin</creatorcontrib><creatorcontrib>Lee, Dong Ho</creatorcontrib><creatorcontrib>Yoon, Jeong Hee</creatorcontrib><creatorcontrib>Kang, Hyo-Jin</creatorcontrib><creatorcontrib>Ahn, Su Joa</creatorcontrib><title>Reproducibility of ultrasound attenuation imaging for the noninvasive evaluation of hepatic steatosis</title><title>Ultrasonography (Seoul, Korea)</title><addtitle>ULTRASONOGRAPHY</addtitle><addtitle>Ultrasonography</addtitle><description>Purpose: The purpose of this study was to evaluate the intra-observer reproducibility of ultrasound attenuation imaging (ATI) for the noninvasive assessment of hepatic steatosis in patients with suspected hepatic steatosis and the inter-observer reproducibility in asymptomatic volunteers.
Methods: This prospective study was approved by our institutional review board and informed consent was obtained from all patients. In group 1, composed of patients with suspected hepatic steatosis (n=143), one abdominal radiologist performed gray-scale ultrasonography and two sessions of ATI. In group 2, composed of healthy volunteers (n=18), three independent sessions of ATI were performed by three abdominal radiologists. The visual degree of hepatic steatosis in all study subjects was graded on a 4-point scale by two independent reviewers using gray-scale ultrasonography. Thereafter, the attenuation coefficient (AC) was correlated with the degree of hepatic steatosis using Spearman rank correlation analysis. Intra-class correlation coefficients (ICCs) were used to assess the intra-observer (group 1) and inter-observer reproducibility (group 2) of ATI measurements.
Results: For the intra-observer reproducibility of ATI, the ICC was 0.929 (95% confidence interval [CI], 0.901 to 0.949), and the coefficient of variation was 7.1%. Inter-observer reproducibility of ATI measurements showed an ICC of 0.792 (95% CI, 0.549 to 0.916). The AC showed a significant correlation with the visual grade of hepatic steatosis for both reviewers (rho, 0.780 and 0.695; P<0.001, respectively).
Conclusion: ATI showed high intra- and inter-observer reproducibility in the assessment of hepatic steatosis.</description><subject>Agreements</subject><subject>Asymptomatic</subject><subject>Biochemistry</subject><subject>Biopsy</subject><subject>Body mass index</subject><subject>Hepatitis</subject><subject>Laboratories</subject><subject>Life Sciences & Biomedicine</subject><subject>Liver diseases</subject><subject>non-alcoholic fatty liver disease</subject><subject>obesity</subject><subject>Original</subject><subject>Radiology, Nuclear Medicine & Medical Imaging</subject><subject>Reproducibility</subject><subject>Science & Technology</subject><subject>Statistical analysis</subject><subject>Ultrasonic imaging</subject><subject>ultrasonography</subject><subject>방사선과학</subject><issn>2288-5919</issn><issn>2288-5943</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNqNkltrGzEQhZfS0oQ0L_0BZaEvveBUt11JL4FgejEECiF9FlrtyJazllxJ65J_X3ntmqZPfZpB-uZwZjhV9RqjK8xo234a0_IKS0TZs-qcECFmjWT0-anH8qy6TGmNEMKYSorFy-qM4lZSwch5BXewjaEfjevc4PJjHWw9DjnqFEbf1zpn8KPOLvjabfTS-WVtQ6zzCmofvPM7ndwOatjp4YgVgRVsS2_qlEHnkFx6Vb2wekhweawX1Y8vn-_n32a3378u5je3M9NwkmctBcq6rtO24VZiShpqcCc7DLix2HCphRCMN7TBPWESC2QoZlZbxIXGPaIX1fuDro9WPRingnZTXQb1ENXN3f1CSbKf37OLA9sHvVbbWNaLj9PA9BDiUulYthhA9VxSi3nfG2aZBCGk4J2EHgjnBmxbtK4PWtux20BvwJcLDk9En_54tyqedoqjtpFCFIF3R4EYfo6Qstq4ZGAYtIcwJkUoJgKJsnRB3_6DrsMYfTmrIu3-JlgIXqgPB8rEkFIEezKDkZqCo0pw1BScAr_52_4J_ROTAnw8AL-gCzYZB97ACSvRarCUhLPSIVpo8f_03OUpN_OSt0x_A6CO4Fk</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Yoo, Jeongin</creator><creator>Lee, Jeong Min</creator><creator>Joo, Ijin</creator><creator>Lee, Dong Ho</creator><creator>Yoon, Jeong Hee</creator><creator>Kang, Hyo-Jin</creator><creator>Ahn, Su Joa</creator><general>Korean Soc Ultrasound Medicine</general><general>Korean Society of Ultrasound in Medicine</general><general>대한초음파의학회</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><scope>ACYCR</scope><orcidid>https://orcid.org/0000-0002-1341-4072</orcidid><orcidid>https://orcid.org/0000-0002-6771-2112</orcidid><orcidid>https://orcid.org/0000-0001-8983-851X</orcidid><orcidid>https://orcid.org/0000-0002-3267-2544</orcidid><orcidid>https://orcid.org/0000-0003-0561-8777</orcidid><orcidid>https://orcid.org/0000-0002-9925-9973</orcidid></search><sort><creationdate>20200401</creationdate><title>Reproducibility of ultrasound attenuation imaging for the noninvasive evaluation of hepatic steatosis</title><author>Yoo, Jeongin ; Lee, Jeong Min ; Joo, Ijin ; Lee, Dong Ho ; Yoon, Jeong Hee ; Kang, Hyo-Jin ; Ahn, Su Joa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c572t-63e34bbbaf57f913253c1b9b1e15f1c79a888475351d249180c314faf078a1d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Agreements</topic><topic>Asymptomatic</topic><topic>Biochemistry</topic><topic>Biopsy</topic><topic>Body mass index</topic><topic>Hepatitis</topic><topic>Laboratories</topic><topic>Life Sciences & Biomedicine</topic><topic>Liver diseases</topic><topic>non-alcoholic fatty liver disease</topic><topic>obesity</topic><topic>Original</topic><topic>Radiology, Nuclear Medicine & Medical Imaging</topic><topic>Reproducibility</topic><topic>Science & Technology</topic><topic>Statistical analysis</topic><topic>Ultrasonic imaging</topic><topic>ultrasonography</topic><topic>방사선과학</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoo, Jeongin</creatorcontrib><creatorcontrib>Lee, Jeong Min</creatorcontrib><creatorcontrib>Joo, Ijin</creatorcontrib><creatorcontrib>Lee, Dong Ho</creatorcontrib><creatorcontrib>Yoon, Jeong Hee</creatorcontrib><creatorcontrib>Kang, Hyo-Jin</creatorcontrib><creatorcontrib>Ahn, Su Joa</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Proquest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><collection>Korean Citation Index</collection><jtitle>Ultrasonography (Seoul, Korea)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoo, Jeongin</au><au>Lee, Jeong Min</au><au>Joo, Ijin</au><au>Lee, Dong Ho</au><au>Yoon, Jeong Hee</au><au>Kang, Hyo-Jin</au><au>Ahn, Su Joa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reproducibility of ultrasound attenuation imaging for the noninvasive evaluation of hepatic steatosis</atitle><jtitle>Ultrasonography (Seoul, Korea)</jtitle><stitle>ULTRASONOGRAPHY</stitle><addtitle>Ultrasonography</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>39</volume><issue>2</issue><spage>121</spage><epage>129</epage><pages>121-129</pages><issn>2288-5919</issn><eissn>2288-5943</eissn><abstract>Purpose: The purpose of this study was to evaluate the intra-observer reproducibility of ultrasound attenuation imaging (ATI) for the noninvasive assessment of hepatic steatosis in patients with suspected hepatic steatosis and the inter-observer reproducibility in asymptomatic volunteers.
Methods: This prospective study was approved by our institutional review board and informed consent was obtained from all patients. In group 1, composed of patients with suspected hepatic steatosis (n=143), one abdominal radiologist performed gray-scale ultrasonography and two sessions of ATI. In group 2, composed of healthy volunteers (n=18), three independent sessions of ATI were performed by three abdominal radiologists. The visual degree of hepatic steatosis in all study subjects was graded on a 4-point scale by two independent reviewers using gray-scale ultrasonography. Thereafter, the attenuation coefficient (AC) was correlated with the degree of hepatic steatosis using Spearman rank correlation analysis. Intra-class correlation coefficients (ICCs) were used to assess the intra-observer (group 1) and inter-observer reproducibility (group 2) of ATI measurements.
Results: For the intra-observer reproducibility of ATI, the ICC was 0.929 (95% confidence interval [CI], 0.901 to 0.949), and the coefficient of variation was 7.1%. Inter-observer reproducibility of ATI measurements showed an ICC of 0.792 (95% CI, 0.549 to 0.916). The AC showed a significant correlation with the visual grade of hepatic steatosis for both reviewers (rho, 0.780 and 0.695; P<0.001, respectively).
Conclusion: ATI showed high intra- and inter-observer reproducibility in the assessment of hepatic steatosis.</abstract><cop>SEOUL</cop><pub>Korean Soc Ultrasound Medicine</pub><pmid>31693842</pmid><doi>10.14366/usg.19034</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-1341-4072</orcidid><orcidid>https://orcid.org/0000-0002-6771-2112</orcidid><orcidid>https://orcid.org/0000-0001-8983-851X</orcidid><orcidid>https://orcid.org/0000-0002-3267-2544</orcidid><orcidid>https://orcid.org/0000-0003-0561-8777</orcidid><orcidid>https://orcid.org/0000-0002-9925-9973</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Agreements Asymptomatic Biochemistry Biopsy Body mass index Hepatitis Laboratories Life Sciences & Biomedicine Liver diseases non-alcoholic fatty liver disease obesity Original Radiology, Nuclear Medicine & Medical Imaging Reproducibility Science & Technology Statistical analysis Ultrasonic imaging ultrasonography 방사선과학 |
| title | Reproducibility of ultrasound attenuation imaging for the noninvasive evaluation of hepatic steatosis |
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