What’s Old Is New: the Evolution of Lymphogranuloma Venereum Proctitis in Persons Living with HIV
Purpose of Review Lymphogranuloma venereum (LGV) has re-emerged as a consequential anorectal sexually transmitted infection with high burden among persons living with HIV, especially men who have sex with men (MSM). Recent Findings Surveillance programs are limited without widely available LGV-speci...
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| Veröffentlicht in: | Current infectious disease reports 2022-08, Vol.24 (8), p.97-104 |
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| creator | Gravett, Ronnie M. Marrazzo, Jeanne |
| description | Purpose of Review
Lymphogranuloma venereum (LGV) has re-emerged as a consequential anorectal sexually transmitted infection with high burden among persons living with HIV, especially men who have sex with men (MSM).
Recent Findings
Surveillance programs are limited without widely available LGV-specific diagnostics, but LGV prevalence is becoming increasingly recognized as it spreads globally. The LGV epidemic remains high among MSM living with HIV and is now shifting to include more HIV-negative MSM. LGV testing of asymptomatic persons at high risk will increase case finding and potential for earlier intervention. Doxycycline remains the guideline-directed treatment of choice, but recent data may support shorter duration or even use of azithromycin as alternatives.
Summary
While the burden of LGV is appreciated as a significant cause of proctitis, especially among MSM living with HIV, lack of accessible diagnostics limits our understanding of actual incidence and its impact on the HIV epidemic. Future directions should include assay validation for widespread use and rigorous clinical trials to examine treatment durations based on symptom burden. |
| doi_str_mv | 10.1007/s11908-022-00781-6 |
| format | Article |
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Lymphogranuloma venereum (LGV) has re-emerged as a consequential anorectal sexually transmitted infection with high burden among persons living with HIV, especially men who have sex with men (MSM).
Recent Findings
Surveillance programs are limited without widely available LGV-specific diagnostics, but LGV prevalence is becoming increasingly recognized as it spreads globally. The LGV epidemic remains high among MSM living with HIV and is now shifting to include more HIV-negative MSM. LGV testing of asymptomatic persons at high risk will increase case finding and potential for earlier intervention. Doxycycline remains the guideline-directed treatment of choice, but recent data may support shorter duration or even use of azithromycin as alternatives.
Summary
While the burden of LGV is appreciated as a significant cause of proctitis, especially among MSM living with HIV, lack of accessible diagnostics limits our understanding of actual incidence and its impact on the HIV epidemic. Future directions should include assay validation for widespread use and rigorous clinical trials to examine treatment durations based on symptom burden.</description><identifier>ISSN: 1523-3847</identifier><identifier>EISSN: 1534-3146</identifier><identifier>DOI: 10.1007/s11908-022-00781-6</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acquired immune deficiency syndrome ; AIDS ; Chlamydia ; Epidemics ; Epidemiology ; HIV ; HIV/AIDS (C Yoon ; Human immunodeficiency virus ; Infectious Diseases ; Medicine ; Medicine & Public Health ; Section Editor ; Sexually transmitted diseases ; STD ; Topical Collection on HIV/AIDS</subject><ispartof>Current infectious disease reports, 2022-08, Vol.24 (8), p.97-104</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-e21cb9d1de53fce1b08bb5a9f3e92e530ca568dc71c0b19b54e27fe43fff483e3</citedby><cites>FETCH-LOGICAL-c319t-e21cb9d1de53fce1b08bb5a9f3e92e530ca568dc71c0b19b54e27fe43fff483e3</cites><orcidid>0000-0002-1614-758X ; 0000-0002-9277-7364</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11908-022-00781-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11908-022-00781-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids></links><search><creatorcontrib>Gravett, Ronnie M.</creatorcontrib><creatorcontrib>Marrazzo, Jeanne</creatorcontrib><title>What’s Old Is New: the Evolution of Lymphogranuloma Venereum Proctitis in Persons Living with HIV</title><title>Current infectious disease reports</title><addtitle>Curr Infect Dis Rep</addtitle><description>Purpose of Review
Lymphogranuloma venereum (LGV) has re-emerged as a consequential anorectal sexually transmitted infection with high burden among persons living with HIV, especially men who have sex with men (MSM).
Recent Findings
Surveillance programs are limited without widely available LGV-specific diagnostics, but LGV prevalence is becoming increasingly recognized as it spreads globally. The LGV epidemic remains high among MSM living with HIV and is now shifting to include more HIV-negative MSM. LGV testing of asymptomatic persons at high risk will increase case finding and potential for earlier intervention. Doxycycline remains the guideline-directed treatment of choice, but recent data may support shorter duration or even use of azithromycin as alternatives.
Summary
While the burden of LGV is appreciated as a significant cause of proctitis, especially among MSM living with HIV, lack of accessible diagnostics limits our understanding of actual incidence and its impact on the HIV epidemic. Future directions should include assay validation for widespread use and rigorous clinical trials to examine treatment durations based on symptom burden.</description><subject>Acquired immune deficiency syndrome</subject><subject>AIDS</subject><subject>Chlamydia</subject><subject>Epidemics</subject><subject>Epidemiology</subject><subject>HIV</subject><subject>HIV/AIDS (C Yoon</subject><subject>Human immunodeficiency virus</subject><subject>Infectious Diseases</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Section Editor</subject><subject>Sexually transmitted diseases</subject><subject>STD</subject><subject>Topical Collection on HIV/AIDS</subject><issn>1523-3847</issn><issn>1534-3146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kMtKw0AUhgdRsFZfwNWA6-hccnUnpdpCsF1oXQ7J5EyTkszUmaSlO1_D1_NJTI3gztW58P3nwIfQNSW3lJDozlGakNgjjHn9GFMvPEEjGnDf49QPT4894x6P_egcXTi3IYQduRGSb2XWfn18OryoCzx3-Bn297gtAU93pu7aymhsFE4PzbY0a5vprjZNhlegwULX4KU1sq3ayuFK4yVYZ7TDabWr9Brvq7bEs_nqEp2prHZw9VvH6PVx-jKZeeniaT55SD3JadJ6wKjMk4IWEHAlgeYkzvMgSxSHhPU7IrMgjAsZUUlymuSBDyxS4HOllB9z4GN0M9zdWvPegWvFxnRW9y8FCxPKQh4lfk-xgZLWOGdBia2tmsweBCXiKFMMMkUvU_zIFGEf4kPI9bBeg_07_U_qGzQceRM</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Gravett, Ronnie M.</creator><creator>Marrazzo, Jeanne</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><orcidid>https://orcid.org/0000-0002-1614-758X</orcidid><orcidid>https://orcid.org/0000-0002-9277-7364</orcidid></search><sort><creationdate>20220801</creationdate><title>What’s Old Is New: the Evolution of Lymphogranuloma Venereum Proctitis in Persons Living with HIV</title><author>Gravett, Ronnie M. ; Marrazzo, Jeanne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-e21cb9d1de53fce1b08bb5a9f3e92e530ca568dc71c0b19b54e27fe43fff483e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>AIDS</topic><topic>Chlamydia</topic><topic>Epidemics</topic><topic>Epidemiology</topic><topic>HIV</topic><topic>HIV/AIDS (C Yoon</topic><topic>Human immunodeficiency virus</topic><topic>Infectious Diseases</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Section Editor</topic><topic>Sexually transmitted diseases</topic><topic>STD</topic><topic>Topical Collection on HIV/AIDS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gravett, Ronnie M.</creatorcontrib><creatorcontrib>Marrazzo, Jeanne</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Current infectious disease reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gravett, Ronnie M.</au><au>Marrazzo, Jeanne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>What’s Old Is New: the Evolution of Lymphogranuloma Venereum Proctitis in Persons Living with HIV</atitle><jtitle>Current infectious disease reports</jtitle><stitle>Curr Infect Dis Rep</stitle><date>2022-08-01</date><risdate>2022</risdate><volume>24</volume><issue>8</issue><spage>97</spage><epage>104</epage><pages>97-104</pages><issn>1523-3847</issn><eissn>1534-3146</eissn><abstract>Purpose of Review
Lymphogranuloma venereum (LGV) has re-emerged as a consequential anorectal sexually transmitted infection with high burden among persons living with HIV, especially men who have sex with men (MSM).
Recent Findings
Surveillance programs are limited without widely available LGV-specific diagnostics, but LGV prevalence is becoming increasingly recognized as it spreads globally. The LGV epidemic remains high among MSM living with HIV and is now shifting to include more HIV-negative MSM. LGV testing of asymptomatic persons at high risk will increase case finding and potential for earlier intervention. Doxycycline remains the guideline-directed treatment of choice, but recent data may support shorter duration or even use of azithromycin as alternatives.
Summary
While the burden of LGV is appreciated as a significant cause of proctitis, especially among MSM living with HIV, lack of accessible diagnostics limits our understanding of actual incidence and its impact on the HIV epidemic. Future directions should include assay validation for widespread use and rigorous clinical trials to examine treatment durations based on symptom burden.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11908-022-00781-6</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1614-758X</orcidid><orcidid>https://orcid.org/0000-0002-9277-7364</orcidid></addata></record> |
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| identifier | ISSN: 1523-3847 |
| ispartof | Current infectious disease reports, 2022-08, Vol.24 (8), p.97-104 |
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| language | eng |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Acquired immune deficiency syndrome AIDS Chlamydia Epidemics Epidemiology HIV HIV/AIDS (C Yoon Human immunodeficiency virus Infectious Diseases Medicine Medicine & Public Health Section Editor Sexually transmitted diseases STD Topical Collection on HIV/AIDS |
| title | What’s Old Is New: the Evolution of Lymphogranuloma Venereum Proctitis in Persons Living with HIV |
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