Cytotoxic furanosesquiterpenoids and steroids from Ircinia mutans sponges

Ircinia mutans Wilson (Irciniidae) is a sponge with antimicrobial and cytotoxic constituents. Our objective was to characterise the cytotoxic constituents of two seasonal collections of I. mutans. The sponges were extracted in methanol-dichloromethane and their constituents were purified and charact...

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Veröffentlicht in:	Pharmaceutical biology 2021-01, Vol.59 (1), p.573-581
Hauptverfasser:	Heidary Jamebozorgi, Fatemeh, Yousefzadi, Morteza, Firuzi, Omidreza, Nazemi, Melika, Zare, Somayeh, Chandran, Jima N., Schneider, Bernd, Baldwin, Ian T., Jassbi, Amir Reza
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Antitumor agents Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cell Line, Tumor Cholesterol Colon cancer Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology Colorectal cancer Colorimetry Column chromatography Cytotoxicity Dichloromethane Drug development Ergosterol Female Furanosesquiterpenes HT29 Cells Humans Inhibitory Concentration 50 Ircinia mutans Leukemia Leukemia - drug therapy Leukemia - pathology marine sponge MCF-7 Cells Molting Natural products Porifera - chemistry Sesquiterpenes - administration & dosage Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Steroid hormones Steroids Steroids - administration & dosage Steroids - isolation & purification Steroids - pharmacology Sterols stigmasterol Summer Tumor cell lines Winter γ-sitosterol
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