Yiguanjian decoction inhibits macrophage M1 polarization and attenuates hepatic fibrosis induced by CCl4/2-AAF

Our previous studies indicated that Yiguanjian decoction (YGJ) has an anti-hepatic-fibrosis effect and could regulate macrophage status. To elucidate the mechanism of YGJ in regulating macrophages. Liver cirrhosis was induced by CCl 4 for 12 weeks combined with 2-acetylaminofluorene (2-AAF) for the...

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Veröffentlicht in:	Pharmaceutical biology 2021-01, Vol.59 (1), p.1148-1158
Hauptverfasser:	Xu, Ying, Xu, Wen, Liu, Wei, Chen, Gaofeng, Jiang, Shili, Chen, Jiamei, Jian, Xun, Zhang, Hua, Liu, Ping, Mu, Yongping
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbon tetrachloride Cell differentiation Chinese medicine Cirrhosis Cytokines Fibrosis hepatic progenitor cells Hospitals Interferon regulatory factor 3 Laboratories Lipopolysaccharides Liver Liver cirrhosis Macrophages Monoclonal antibodies NF-κB protein Olive oil Oral administration Phenotypes Polarization Polyclonal antibodies Rodents Signal transduction Sox9 protein Stat1 protein Wnt protein Wnt signalling pathway β-Catenin
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