Bioadhesive hydrogel comprising bilirubin/β-cyclodextrin inclusion complexes promote diabetic wound healing

Chronic non-healing diabetic wound therapy is an important clinical challenge. Manipulating the release of bioactive factors from an adhesive hydrogel is an effective approach to repair chronic wounds. As an endogenous antioxidant, bilirubin (BR) has been shown to promote wound healing. Nonetheless,...

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Veröffentlicht in:	Pharmaceutical biology 2021-12, Vol.59 (1), p.1137-1147
Hauptverfasser:	Yao, Qing, Shi, Yannan, Xia, Xing, Tang, Yingying, Jiang, Xue, Zheng, Ya-Wen, Zhang, Hailin, Chen, Ruijie, Kou, Longfa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesives Animals anti-inflammation Antioxidants Antioxidants - administration & dosage Antioxidants - chemistry Antioxidants - pharmacology beta-Cyclodextrins - chemistry Bilirubin Bilirubin - administration & dosage Bilirubin - chemistry Bilirubin - pharmacology bilirubin inclusion complex Collagen Collagen - metabolism Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Human Umbilical Vein Endothelial Cells Humans Hydrogels macrophage polarization Rats rheological characterization Rodents Solubility Thiolated polyglutamic acid Time Factors tissue remodelling Tumor necrosis factor-α Vascular endothelial growth factor Wound healing Wound Healing - drug effects Wounds and Injuries - drug therapy Wounds and Injuries - etiology β-Cyclodextrin
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