A single-nucleotide polymorphism of IL12A gene (rs582537 A/C/G) and susceptibility to chronic hepatitis B virus infection among Iraqi patients
A case–control study (80 patients with chronic hepatitis B virus [HBV] infection and 96 controls) was performed to evaluate the association of an IL12A gene variant (rs582537 A/C/G) with HBV infection. Allele G showed a significantly lower frequency in patients compared to controls (31.2 vs . 46.9%;...
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| Veröffentlicht in: | Egyptian Journal of Medical Human Genetics 2022-07, Vol.23 (1), p.1-3, Article 110 |
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| creator | Mohsen, Rana T. Al-Azzawi, Raghad H. Ad’hiah, Ali H. |
| description | A case–control study (80 patients with chronic hepatitis B virus [HBV] infection and 96 controls) was performed to evaluate the association of an
IL12A
gene variant (rs582537 A/C/G) with HBV infection. Allele
G
showed a significantly lower frequency in patients compared to controls (31.2
vs
. 46.9%; probability [
p
] = 0.009; corrected
p
[
pc
] = 0.027) and was associated with a lower risk of HBV infection (odds ratio [OR] = 0.49; 95% confidence interval [CI] = 0.29–0.83). A similar lower risk was associated with genotypes CG (17.5
vs
. 29.2; OR = 0.25; 95% CI = 0.08–0.81;
p
= 0.02) and GG (10.0
vs
. 16.7; OR = 0.25; 95% CI = 0.07–0.91;
p
= 0.036), but the
pc
value was not significant (0.12 and 0.126, respectively). Serum IL-35 levels showed significant differences between individuals of different genotypes (
p
= 0.007). The highest median was associated with CA genotype (286.5 pg/mL), followed by genotypes CG (227.0 pg/mL), GG (206.5 pg/mL), CC (169.0 pg/mL), AA (137.5 pg/mL) and finally AG (125.0 pg/mL). In conclusion, rs582537 appears to be an important genetic variant that may influence not only susceptibility to HBV infection but IL-35 levels. |
| doi_str_mv | 10.1186/s43042-022-00322-9 |
| format | Article |
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IL12A
gene variant (rs582537 A/C/G) with HBV infection. Allele
G
showed a significantly lower frequency in patients compared to controls (31.2
vs
. 46.9%; probability [
p
] = 0.009; corrected
p
[
pc
] = 0.027) and was associated with a lower risk of HBV infection (odds ratio [OR] = 0.49; 95% confidence interval [CI] = 0.29–0.83). A similar lower risk was associated with genotypes CG (17.5
vs
. 29.2; OR = 0.25; 95% CI = 0.08–0.81;
p
= 0.02) and GG (10.0
vs
. 16.7; OR = 0.25; 95% CI = 0.07–0.91;
p
= 0.036), but the
pc
value was not significant (0.12 and 0.126, respectively). Serum IL-35 levels showed significant differences between individuals of different genotypes (
p
= 0.007). The highest median was associated with CA genotype (286.5 pg/mL), followed by genotypes CG (227.0 pg/mL), GG (206.5 pg/mL), CC (169.0 pg/mL), AA (137.5 pg/mL) and finally AG (125.0 pg/mL). In conclusion, rs582537 appears to be an important genetic variant that may influence not only susceptibility to HBV infection but IL-35 levels.</description><identifier>ISSN: 2090-2441</identifier><identifier>ISSN: 1110-8630</identifier><identifier>EISSN: 2090-2441</identifier><identifier>DOI: 10.1186/s43042-022-00322-9</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Chronic infection ; Comparative analysis ; Correspondence ; Disease susceptibility ; Gene polymorphism ; Genes ; Genetic aspects ; Genetic diversity ; Genetic research ; Health aspects ; Hepatitis B ; Hepatitis B virus ; IL12A ; IL12A gene ; Infection ; Infections ; Interferon ; Interleukin-35 ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; rs582537 ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism</subject><ispartof>Egyptian Journal of Medical Human Genetics, 2022-07, Vol.23 (1), p.1-3, Article 110</ispartof><rights>The Author(s) 2022</rights><rights>COPYRIGHT 2022 Springer</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c447t-7cbcf3c73b4d93d1aed9dd9f7243ba7dbe99d86444cdb615a06f6d8361fd845d3</cites><orcidid>0000-0002-2445-2242</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids></links><search><creatorcontrib>Mohsen, Rana T.</creatorcontrib><creatorcontrib>Al-Azzawi, Raghad H.</creatorcontrib><creatorcontrib>Ad’hiah, Ali H.</creatorcontrib><title>A single-nucleotide polymorphism of IL12A gene (rs582537 A/C/G) and susceptibility to chronic hepatitis B virus infection among Iraqi patients</title><title>Egyptian Journal of Medical Human Genetics</title><addtitle>Egypt J Med Hum Genet</addtitle><description>A case–control study (80 patients with chronic hepatitis B virus [HBV] infection and 96 controls) was performed to evaluate the association of an
IL12A
gene variant (rs582537 A/C/G) with HBV infection. Allele
G
showed a significantly lower frequency in patients compared to controls (31.2
vs
. 46.9%; probability [
p
] = 0.009; corrected
p
[
pc
] = 0.027) and was associated with a lower risk of HBV infection (odds ratio [OR] = 0.49; 95% confidence interval [CI] = 0.29–0.83). A similar lower risk was associated with genotypes CG (17.5
vs
. 29.2; OR = 0.25; 95% CI = 0.08–0.81;
p
= 0.02) and GG (10.0
vs
. 16.7; OR = 0.25; 95% CI = 0.07–0.91;
p
= 0.036), but the
pc
value was not significant (0.12 and 0.126, respectively). Serum IL-35 levels showed significant differences between individuals of different genotypes (
p
= 0.007). The highest median was associated with CA genotype (286.5 pg/mL), followed by genotypes CG (227.0 pg/mL), GG (206.5 pg/mL), CC (169.0 pg/mL), AA (137.5 pg/mL) and finally AG (125.0 pg/mL). In conclusion, rs582537 appears to be an important genetic variant that may influence not only susceptibility to HBV infection but IL-35 levels.</description><subject>Chronic infection</subject><subject>Comparative analysis</subject><subject>Correspondence</subject><subject>Disease susceptibility</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic diversity</subject><subject>Genetic research</subject><subject>Health aspects</subject><subject>Hepatitis B</subject><subject>Hepatitis B virus</subject><subject>IL12A</subject><subject>IL12A gene</subject><subject>Infection</subject><subject>Infections</subject><subject>Interferon</subject><subject>Interleukin-35</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>rs582537</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><issn>2090-2441</issn><issn>1110-8630</issn><issn>2090-2441</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNp9Ustq3DAUNaWFppP8QFaCbtqFM3r5oaU7tMnAQDfpWsh6eDTYkiPJhfmJfHOVuCQtlCKudLmcc7g6nKK4RvAGobbeRkogxSXEuSDJN3tTXGDIYIkpRW__6N8XH2I8QVhXpKEXxWMHonXDqEu3yFH7ZJUGsx_Pkw_z0cYJeAP2B4Q7MGinwacQqxZnLui2u-3tZyCcAnGJUs_J9na06QySB_IYvLMSHPUskk02gi_gpw1LBNYZLZP1DojJuwHsg3iw4AmlXYqXxTsjxqivfr-b4se3r_e7u_Lw_Xa_6w6lpLRJZSN7aYhsSE8VIwoJrZhSzDSYkl40qteMqbamlErV16gSsDa1akmNjGpppcim2K-6yosTn4OdRDhzLyx_HvgwcBGSzY5wRQSupcG9IYzCqmXCNDC7rQnFvc5ub4qPq9Yc_MOiY-InvwSX1-e4bhkliDDyihpEFs0u-BSEnGyUvGsQxKzK6hl18w9UPkpPVnqnjc3zvwh4JcjgYwzavHwGQf4UDb5Gg-do8OdocJZJZCXFDHaDDq8b_4f1Cx2ZuiA</recordid><startdate>20220714</startdate><enddate>20220714</enddate><creator>Mohsen, Rana T.</creator><creator>Al-Azzawi, Raghad H.</creator><creator>Ad’hiah, Ali H.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-2445-2242</orcidid></search><sort><creationdate>20220714</creationdate><title>A single-nucleotide polymorphism of IL12A gene (rs582537 A/C/G) and susceptibility to chronic hepatitis B virus infection among Iraqi patients</title><author>Mohsen, Rana T. ; Al-Azzawi, Raghad H. ; Ad’hiah, Ali H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-7cbcf3c73b4d93d1aed9dd9f7243ba7dbe99d86444cdb615a06f6d8361fd845d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Chronic infection</topic><topic>Comparative analysis</topic><topic>Correspondence</topic><topic>Disease susceptibility</topic><topic>Gene polymorphism</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic diversity</topic><topic>Genetic research</topic><topic>Health aspects</topic><topic>Hepatitis B</topic><topic>Hepatitis B virus</topic><topic>IL12A</topic><topic>IL12A gene</topic><topic>Infection</topic><topic>Infections</topic><topic>Interferon</topic><topic>Interleukin-35</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>rs582537</topic><topic>Single nucleotide polymorphisms</topic><topic>Single-nucleotide polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohsen, Rana T.</creatorcontrib><creatorcontrib>Al-Azzawi, Raghad H.</creatorcontrib><creatorcontrib>Ad’hiah, Ali H.</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Egyptian Journal of Medical Human Genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohsen, Rana T.</au><au>Al-Azzawi, Raghad H.</au><au>Ad’hiah, Ali H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A single-nucleotide polymorphism of IL12A gene (rs582537 A/C/G) and susceptibility to chronic hepatitis B virus infection among Iraqi patients</atitle><jtitle>Egyptian Journal of Medical Human Genetics</jtitle><stitle>Egypt J Med Hum Genet</stitle><date>2022-07-14</date><risdate>2022</risdate><volume>23</volume><issue>1</issue><spage>1</spage><epage>3</epage><pages>1-3</pages><artnum>110</artnum><issn>2090-2441</issn><issn>1110-8630</issn><eissn>2090-2441</eissn><abstract>A case–control study (80 patients with chronic hepatitis B virus [HBV] infection and 96 controls) was performed to evaluate the association of an
IL12A
gene variant (rs582537 A/C/G) with HBV infection. Allele
G
showed a significantly lower frequency in patients compared to controls (31.2
vs
. 46.9%; probability [
p
] = 0.009; corrected
p
[
pc
] = 0.027) and was associated with a lower risk of HBV infection (odds ratio [OR] = 0.49; 95% confidence interval [CI] = 0.29–0.83). A similar lower risk was associated with genotypes CG (17.5
vs
. 29.2; OR = 0.25; 95% CI = 0.08–0.81;
p
= 0.02) and GG (10.0
vs
. 16.7; OR = 0.25; 95% CI = 0.07–0.91;
p
= 0.036), but the
pc
value was not significant (0.12 and 0.126, respectively). Serum IL-35 levels showed significant differences between individuals of different genotypes (
p
= 0.007). The highest median was associated with CA genotype (286.5 pg/mL), followed by genotypes CG (227.0 pg/mL), GG (206.5 pg/mL), CC (169.0 pg/mL), AA (137.5 pg/mL) and finally AG (125.0 pg/mL). In conclusion, rs582537 appears to be an important genetic variant that may influence not only susceptibility to HBV infection but IL-35 levels.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s43042-022-00322-9</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0002-2445-2242</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature OA/Free Journals |
| subjects | Chronic infection Comparative analysis Correspondence Disease susceptibility Gene polymorphism Genes Genetic aspects Genetic diversity Genetic research Health aspects Hepatitis B Hepatitis B virus IL12A IL12A gene Infection Infections Interferon Interleukin-35 Medical research Medicine Medicine & Public Health Medicine, Experimental rs582537 Single nucleotide polymorphisms Single-nucleotide polymorphism |
| title | A single-nucleotide polymorphism of IL12A gene (rs582537 A/C/G) and susceptibility to chronic hepatitis B virus infection among Iraqi patients |
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