Ball-milled valsartan and its combination with mannitol: the case of drug polyamorphism

Valsartan (VAL) is a drug that has low water solubility and low oral bioavailability. Unlike most drugs, bulk VAL has unusual solid-state properties, including the phenomenon of polyamorphism. Furthermore, surprisingly, obtaining the neat VAL in a completely amorphous form does not increase its solu...

Ausführliche Beschreibung