Low dimensional Bi2Se3 NPs/reduced graphene oxide nanocomposite for simultaneous detection of L-Dopa and acetaminophen in presence of ascorbic acid in biological samples and pharmaceuticals
Graphene-based inorganic layered materials have developed as a versatile, new class of nanomaterials and drawn huge scientific interest, owing to its thickness-dependent physical properties, exfoliated two-dimensional crystals in various technological and industrial applications. This work is the fi...
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| Veröffentlicht in: | Journal of nanostructure in chemistry 2022-08, Vol.12 (4), p.513-528 |
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| creator | Gorle, Govinda Bathinapatla, Ayyappa Kanchi, Suvardhan Ling, Yong Chien Rezakazemi, Mashallah |
| description | Graphene-based inorganic layered materials have developed as a versatile, new class of nanomaterials and drawn huge scientific interest, owing to its thickness-dependent physical properties, exfoliated two-dimensional crystals in various technological and industrial applications. This work is the first demonstration of the fabrication of low dimensional bismuth selenide (Bi
2
Se
3
) NPs functionalized reduced graphene oxide (rGO) on the platinum electrode (Pt-E) for the ultra-sensitive and simultaneous detection of acetaminophen (ACT) and L-DOPA (LD) in the presence of ascorbic acid (AA) in various biological samples and pharmaceuticals. The constructed electrode accelerates the electron transfer reactions of LD and ACT without interfering with the electron transfer reactions of AA, which was an electroactive coexisting chemical. At pH 6.0 in 0.1 M phosphate buffer solution, Bi
2
Se
3
NPs/rGO/Pt-E showed a sixfold and fivefold increase in cyclic voltammetry for LD and ACT signals, respectively, when compared to bare Pt-E. Under the optimal conditions, differential pulse voltammetry (DPV) demonstrated that the anodic peak currents were linearly dependent on the concentrations of LD (0.006–0.25 mM) and ACT (0.0045–0.14 mM) at anodic peak potentials of + 0.25 and + 0.52 V, respectively. With a signal to noise (S/N) ratio of 3, acceptable detection limits of 0.23 and 0.17 M were achieved for both LD and ACT, with strong intra- and inter-electrode repeatability. Overall, the fabricated nanosensor offered numerous advantages including ease to fabricate, ultra-sensitivity, good stability, and reproducibility towards the detection of LD and ACT in various bioloical samples and pharmaceuticals. The amounts of LD and ACT were also identified in commercial pharmaceuticals and synthetic urine samples to validate the applicability of the modified electrode. |
| doi_str_mv | 10.1007/s40097-021-00428-3 |
| format | Article |
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2
Se
3
) NPs functionalized reduced graphene oxide (rGO) on the platinum electrode (Pt-E) for the ultra-sensitive and simultaneous detection of acetaminophen (ACT) and L-DOPA (LD) in the presence of ascorbic acid (AA) in various biological samples and pharmaceuticals. The constructed electrode accelerates the electron transfer reactions of LD and ACT without interfering with the electron transfer reactions of AA, which was an electroactive coexisting chemical. At pH 6.0 in 0.1 M phosphate buffer solution, Bi
2
Se
3
NPs/rGO/Pt-E showed a sixfold and fivefold increase in cyclic voltammetry for LD and ACT signals, respectively, when compared to bare Pt-E. Under the optimal conditions, differential pulse voltammetry (DPV) demonstrated that the anodic peak currents were linearly dependent on the concentrations of LD (0.006–0.25 mM) and ACT (0.0045–0.14 mM) at anodic peak potentials of + 0.25 and + 0.52 V, respectively. With a signal to noise (S/N) ratio of 3, acceptable detection limits of 0.23 and 0.17 M were achieved for both LD and ACT, with strong intra- and inter-electrode repeatability. Overall, the fabricated nanosensor offered numerous advantages including ease to fabricate, ultra-sensitivity, good stability, and reproducibility towards the detection of LD and ACT in various bioloical samples and pharmaceuticals. The amounts of LD and ACT were also identified in commercial pharmaceuticals and synthetic urine samples to validate the applicability of the modified electrode.</description><identifier>ISSN: 2008-9244</identifier><identifier>EISSN: 2193-8865</identifier><identifier>DOI: 10.1007/s40097-021-00428-3</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acceptable noise levels ; Analgesics ; Ascorbic acid ; Biological properties ; Bismuth ; Buffer solutions ; Chemical reactions ; Chemistry ; Chemistry and Materials Science ; Computer Applications in Chemistry ; Electrodes ; Electron transfer ; Graphene ; Industrial applications ; Inorganic Chemistry ; Layered materials ; Nanochemistry ; Nanocomposites ; Nanomaterials ; Nanosensors ; Organic Chemistry ; Original Research ; Pharmaceuticals ; Physical Chemistry ; Physical properties ; Polymer Sciences ; Reproducibility ; Voltammetry</subject><ispartof>Journal of nanostructure in chemistry, 2022-08, Vol.12 (4), p.513-528</ispartof><rights>Islamic Azad University 2021</rights><rights>Islamic Azad University 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-d2cdafdebcad57e3eb2435434a7294dc34b9d45e16003ac0138bd0f0147db453</citedby><cites>FETCH-LOGICAL-c319t-d2cdafdebcad57e3eb2435434a7294dc34b9d45e16003ac0138bd0f0147db453</cites><orcidid>0000-0002-9980-6682</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40097-021-00428-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40097-021-00428-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids></links><search><creatorcontrib>Gorle, Govinda</creatorcontrib><creatorcontrib>Bathinapatla, Ayyappa</creatorcontrib><creatorcontrib>Kanchi, Suvardhan</creatorcontrib><creatorcontrib>Ling, Yong Chien</creatorcontrib><creatorcontrib>Rezakazemi, Mashallah</creatorcontrib><title>Low dimensional Bi2Se3 NPs/reduced graphene oxide nanocomposite for simultaneous detection of L-Dopa and acetaminophen in presence of ascorbic acid in biological samples and pharmaceuticals</title><title>Journal of nanostructure in chemistry</title><addtitle>J Nanostruct Chem</addtitle><description>Graphene-based inorganic layered materials have developed as a versatile, new class of nanomaterials and drawn huge scientific interest, owing to its thickness-dependent physical properties, exfoliated two-dimensional crystals in various technological and industrial applications. This work is the first demonstration of the fabrication of low dimensional bismuth selenide (Bi
2
Se
3
) NPs functionalized reduced graphene oxide (rGO) on the platinum electrode (Pt-E) for the ultra-sensitive and simultaneous detection of acetaminophen (ACT) and L-DOPA (LD) in the presence of ascorbic acid (AA) in various biological samples and pharmaceuticals. The constructed electrode accelerates the electron transfer reactions of LD and ACT without interfering with the electron transfer reactions of AA, which was an electroactive coexisting chemical. At pH 6.0 in 0.1 M phosphate buffer solution, Bi
2
Se
3
NPs/rGO/Pt-E showed a sixfold and fivefold increase in cyclic voltammetry for LD and ACT signals, respectively, when compared to bare Pt-E. Under the optimal conditions, differential pulse voltammetry (DPV) demonstrated that the anodic peak currents were linearly dependent on the concentrations of LD (0.006–0.25 mM) and ACT (0.0045–0.14 mM) at anodic peak potentials of + 0.25 and + 0.52 V, respectively. With a signal to noise (S/N) ratio of 3, acceptable detection limits of 0.23 and 0.17 M were achieved for both LD and ACT, with strong intra- and inter-electrode repeatability. Overall, the fabricated nanosensor offered numerous advantages including ease to fabricate, ultra-sensitivity, good stability, and reproducibility towards the detection of LD and ACT in various bioloical samples and pharmaceuticals. The amounts of LD and ACT were also identified in commercial pharmaceuticals and synthetic urine samples to validate the applicability of the modified electrode.</description><subject>Acceptable noise levels</subject><subject>Analgesics</subject><subject>Ascorbic acid</subject><subject>Biological properties</subject><subject>Bismuth</subject><subject>Buffer solutions</subject><subject>Chemical reactions</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Computer Applications in Chemistry</subject><subject>Electrodes</subject><subject>Electron transfer</subject><subject>Graphene</subject><subject>Industrial applications</subject><subject>Inorganic Chemistry</subject><subject>Layered materials</subject><subject>Nanochemistry</subject><subject>Nanocomposites</subject><subject>Nanomaterials</subject><subject>Nanosensors</subject><subject>Organic Chemistry</subject><subject>Original Research</subject><subject>Pharmaceuticals</subject><subject>Physical Chemistry</subject><subject>Physical properties</subject><subject>Polymer Sciences</subject><subject>Reproducibility</subject><subject>Voltammetry</subject><issn>2008-9244</issn><issn>2193-8865</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kctu1TAQhiMEUqvSF2BliXXo-JITewnlKh1BJbq3HHty6urEDp5EwNv0SVjwZHU4SOzwZizN93-y_DfNCw6vOEB_RQrA9C0I3gIooVv5pDkX3MhW6133tN4BdGuEUmfNJdE91GOMNBrOm1_7_J2FOGGimJM7sjdRfEXJPt_QVcGwegzsUNx8hwlZ_hEDsuRS9nmaM8UF2ZgLozitx8UlzCuxgAv6pcpYHtm-fZtnx1wKzHlc3BRT3lwsJjYXJEweN86Rz2WIvlIxbMsh5mM-RF9fRG6aj0i_HzbLfOfKVFXrsu3oefNsrAMv_86L5vb9u9vrj-3-y4dP16_3rZfcLG0QPrgx4OBd6HqUOAglOyWV64VRwUs1mKA65DsA6TxwqYcAI3DVh0F18qJ5edLOJX9bkRZ7n9dSv4us2Gnd77TqRaXEifIlExUc7Vzi5MpPy8FuTdlTU7Y2Zf80ZWUNyVOIKpwOWP6p_5N6BOdCm6M</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Gorle, Govinda</creator><creator>Bathinapatla, Ayyappa</creator><creator>Kanchi, Suvardhan</creator><creator>Ling, Yong Chien</creator><creator>Rezakazemi, Mashallah</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><orcidid>https://orcid.org/0000-0002-9980-6682</orcidid></search><sort><creationdate>20220801</creationdate><title>Low dimensional Bi2Se3 NPs/reduced graphene oxide nanocomposite for simultaneous detection of L-Dopa and acetaminophen in presence of ascorbic acid in biological samples and pharmaceuticals</title><author>Gorle, Govinda ; Bathinapatla, Ayyappa ; Kanchi, Suvardhan ; Ling, Yong Chien ; Rezakazemi, Mashallah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-d2cdafdebcad57e3eb2435434a7294dc34b9d45e16003ac0138bd0f0147db453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acceptable noise levels</topic><topic>Analgesics</topic><topic>Ascorbic acid</topic><topic>Biological properties</topic><topic>Bismuth</topic><topic>Buffer solutions</topic><topic>Chemical reactions</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Computer Applications in Chemistry</topic><topic>Electrodes</topic><topic>Electron transfer</topic><topic>Graphene</topic><topic>Industrial applications</topic><topic>Inorganic Chemistry</topic><topic>Layered materials</topic><topic>Nanochemistry</topic><topic>Nanocomposites</topic><topic>Nanomaterials</topic><topic>Nanosensors</topic><topic>Organic Chemistry</topic><topic>Original Research</topic><topic>Pharmaceuticals</topic><topic>Physical Chemistry</topic><topic>Physical properties</topic><topic>Polymer Sciences</topic><topic>Reproducibility</topic><topic>Voltammetry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gorle, Govinda</creatorcontrib><creatorcontrib>Bathinapatla, Ayyappa</creatorcontrib><creatorcontrib>Kanchi, Suvardhan</creatorcontrib><creatorcontrib>Ling, Yong Chien</creatorcontrib><creatorcontrib>Rezakazemi, Mashallah</creatorcontrib><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Journal of nanostructure in chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gorle, Govinda</au><au>Bathinapatla, Ayyappa</au><au>Kanchi, Suvardhan</au><au>Ling, Yong Chien</au><au>Rezakazemi, Mashallah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low dimensional Bi2Se3 NPs/reduced graphene oxide nanocomposite for simultaneous detection of L-Dopa and acetaminophen in presence of ascorbic acid in biological samples and pharmaceuticals</atitle><jtitle>Journal of nanostructure in chemistry</jtitle><stitle>J Nanostruct Chem</stitle><date>2022-08-01</date><risdate>2022</risdate><volume>12</volume><issue>4</issue><spage>513</spage><epage>528</epage><pages>513-528</pages><issn>2008-9244</issn><eissn>2193-8865</eissn><abstract>Graphene-based inorganic layered materials have developed as a versatile, new class of nanomaterials and drawn huge scientific interest, owing to its thickness-dependent physical properties, exfoliated two-dimensional crystals in various technological and industrial applications. This work is the first demonstration of the fabrication of low dimensional bismuth selenide (Bi
2
Se
3
) NPs functionalized reduced graphene oxide (rGO) on the platinum electrode (Pt-E) for the ultra-sensitive and simultaneous detection of acetaminophen (ACT) and L-DOPA (LD) in the presence of ascorbic acid (AA) in various biological samples and pharmaceuticals. The constructed electrode accelerates the electron transfer reactions of LD and ACT without interfering with the electron transfer reactions of AA, which was an electroactive coexisting chemical. At pH 6.0 in 0.1 M phosphate buffer solution, Bi
2
Se
3
NPs/rGO/Pt-E showed a sixfold and fivefold increase in cyclic voltammetry for LD and ACT signals, respectively, when compared to bare Pt-E. Under the optimal conditions, differential pulse voltammetry (DPV) demonstrated that the anodic peak currents were linearly dependent on the concentrations of LD (0.006–0.25 mM) and ACT (0.0045–0.14 mM) at anodic peak potentials of + 0.25 and + 0.52 V, respectively. With a signal to noise (S/N) ratio of 3, acceptable detection limits of 0.23 and 0.17 M were achieved for both LD and ACT, with strong intra- and inter-electrode repeatability. Overall, the fabricated nanosensor offered numerous advantages including ease to fabricate, ultra-sensitivity, good stability, and reproducibility towards the detection of LD and ACT in various bioloical samples and pharmaceuticals. The amounts of LD and ACT were also identified in commercial pharmaceuticals and synthetic urine samples to validate the applicability of the modified electrode.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s40097-021-00428-3</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-9980-6682</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Acceptable noise levels Analgesics Ascorbic acid Biological properties Bismuth Buffer solutions Chemical reactions Chemistry Chemistry and Materials Science Computer Applications in Chemistry Electrodes Electron transfer Graphene Industrial applications Inorganic Chemistry Layered materials Nanochemistry Nanocomposites Nanomaterials Nanosensors Organic Chemistry Original Research Pharmaceuticals Physical Chemistry Physical properties Polymer Sciences Reproducibility Voltammetry |
| title | Low dimensional Bi2Se3 NPs/reduced graphene oxide nanocomposite for simultaneous detection of L-Dopa and acetaminophen in presence of ascorbic acid in biological samples and pharmaceuticals |
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